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Preparation and Application of Light/Temperature Sensitive Amphiphilic Block Polymer Micelle

An amphiphilic block and temperature-sensitive technology, which is used in the synthesis and application of light/temperature amphiphilic block polymers, can solve problems such as unsatisfactory effects, achieve precise drug release, and have broad application prospects Effect

Inactive Publication Date: 2017-08-11
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the research on the precise regulation of the behavior of polymer substances has not yet achieved the desired effect

Method used

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  • Preparation and Application of Light/Temperature Sensitive Amphiphilic Block Polymer Micelle
  • Preparation and Application of Light/Temperature Sensitive Amphiphilic Block Polymer Micelle
  • Preparation and Application of Light/Temperature Sensitive Amphiphilic Block Polymer Micelle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of macromolecular chain transfer agent poly(nitrogen-isopropylacrylamide): nitrogen-isopropylacrylamide, azobisisobutyronitrile and trithiocarbonate were dissolved in nitrogen, nitrogen-dimethylformaldehyde Amide / water (volume ratio 90:10) mixed solution in the Schrenk flask, stirred for 30 minutes until completely dissolved, nitrogen gas for 30 minutes to remove oxygen, after six cycles of "freezing-pumping-thawing" placed in The reaction was carried out in an oil bath at 70°C for 4 hours, quenched with liquid nitrogen and left open to terminate the polymerization reaction. The reacted solution was dialyzed in deionized water for 48 hours with a molecular weight cut-off of 1000 to remove unreacted nitrogen-isopropylacrylamide and solvent nitrogen, nitrogen-dimethylformamide, and the dialysate was freeze-dried The crude product was obtained, and then precipitated three times with cold ether, and dried in vacuum at 45° C. for 48 hours to obtain a pale yellow ...

Embodiment 2

[0034] Preparation of macromolecular chain transfer agent: nitrogen-isopropylacrylamide, azobisisobutyronitrile and trithiocarbonate are dissolved in nitrogen, the mixed solution of nitrogen-dimethylformamide / water (volume ratio is 95:5) in a Schrenck flask, stirred for 40 minutes until it was completely dissolved, passed nitrogen for 60 minutes to remove oxygen, and after six cycles of "freezing-pumping-thawing", placed it in a 70°C oil bath for 8 hours. The polymerization was terminated by quenching with liquid nitrogen and leaving open. The solution after the reaction was dialyzed in deionized water for 48 hours with a dialysis bag with a molecular weight cut-off of 2500 to remove unreacted nitrogen-isopropylacrylamide and solvent nitrogen, nitrogen-dimethylformamide, and the dialysate was freeze-dried The crude product was obtained, and then precipitated three times with cold ether, and dried under vacuum at 50° C. for 48 hours to obtain the light yellow final product poly...

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Abstract

The invention provides a method for preparing a light / temperature dual-response block polymer self-assembly based on nitrophenyl ester and isopropylacetamide and application thereof. The method comprises the following steps: preparing an amphiphilic block copolymer, namely poly(N-isopropylacrylamide)-block-poly(2-nitrobenzyl methacrylate) (PNIPAM-b-PNBM) by means of twice reversible-addition chain transfer polymerizations. The polymer can be self-assembled into micelle in water, wherein the poly(N-isopropylacrylamide)-block with temperature response is used as a shell of the micelle, the poly(2-nitrobenzyl methacrylate) block with light response is used as a core of the micelle, and hydrophobic Nile red molecules can be loaded inside the micelle. Under external stimulation, the appearance of the micelle can change if light / temperature changes, and the balance of hydrophilicity and hydrophobicity of the micelle is destroyed, so that the guest molecule Nile red loaded in the micelle can be released. The light / temperature dual-response block polymer self-assembly has light response and temperature response, and has a wide application prospect in the field of drug controlled-release.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to the synthesis and application of a light / temperature amphiphilic block polymer based on nitrophenyl ester and isopropylamide. Background technique [0002] In recent years, due to the application of stimuli-responsive block polymer micelles in the fields of catalysis, nanotechnology, smart membranes and drug delivery, researchers have attracted extensive attention. Among them, photoresponsive polymers have become one of the research hotspots at home and abroad due to their advantages such as cleanliness and remote control (precisely adjusting their wavelength and intensity). Based on the complexity of many macromolecular biological processes such as proteins, nucleic acids, and polysaccharides in nature, it is necessary to design a multi-responsive polymer containing photoresponsive groups. [0003] At present, the research on the precise regulation of the behavior o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C08F220/34C08F2/38C08J3/07A61K47/32
Inventor 王国杰杨芳曹自权
Owner UNIV OF SCI & TECH BEIJING