Device and method for examining a phase distribution used to determine a pathological interaction between different areas of the brain
A phase distribution and equipment technology, applied in applications, electrotherapy, electroencephalography, etc., can solve problems such as inability to distinguish pathological power spectral density to be evaluated
Active Publication Date: 2015-07-08
FORSCHUNGSZENTRUM JUELICH GMBH
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With standard stimulus feedback (see for example "A summation technique for the detection of small evoked potentials" by G.D. Dawson, published in Electroencephalogr. Clin. Neurophysiol. 44 , 1954, pp. 153-154; M. "Magnetoencephalography: Theory, instrumentation, and applications to noninvasive research of the human brain" by R. Hari, R.J. Ilmoniemi, J. Knuutila, and O.V. ive studies of the working human brain"), published in Rev. Mod. Phys., Vol. 65, 1993, pp. 413-497) also fails to address the problem posed by the inability to distinguish between pathological and non-pathological power spectral density
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[0011] figure 1 A schematic diagram of a device 1 for examining pathological interactions between different brain regions is shown. The device 1 consists of a control and evaluation unit 10 , a stimulation unit 11 and a measurement unit 12 . During operation of the device 1 , the control and analysis unit 10 in particular implements the control of the stimulation unit 11 . To this end, the control and evaluation unit 10 generates a control signal 21 which is received by the stimulation unit 11 . With the aid of this control signal 21 , the stimulation unit 11 generates a stimulus 22 which is applied to the patient. The stimuli 22 are applied successively to the patient with the same individual stimuli and are intended to stimulate neurons in the patient's brain region to be examined.
[0012] The stimulation effect achieved by stimulation 22 is detected by means of measuring unit 12 . The measurement unit 12 receives one or more measurement signals 23 measured on the patie...
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The invention relates to a device (1) for examining a pathological interaction between different brain areas, comprising a stimulation unit (11), which administers identical stimuli (22) to a patient in a sequential manner, wherein the stimuli stimulate neurons of the patient in the brain areas to be examined, a measuring unit (12) for recording measurement signals (23) that represent a neural activity of the stimulated neurons, and a control and analysis unit (10) for controlling the stimulation unit and for analyzing the measurement signals. According to the invention, the control and analysis unit transforms the measurement signals into the complex plane, examines the distribution of the phases of stimuli of the measurement signals absorbed by the measuring unit in response to the stimuli delivered to the patient, and determines the probability, with which the phase distribution differs from a uniform distribution, in order to ascertain whether a pathological interaction between the brain areas exists.
Description
technical field [0001] The present invention relates to a device and a method for examining pathological interactions between different brain regions. Background technique [0002] A number of neurological and psychiatric disorders are characterized by pathologically increased synchronization of neuronal populations (see for example "Pathological Synchronization in Parkinson's Disease: Networks, Models" by C. Hammond, H. Bergman and P. Brown and treatment" ("Pathological synchronization in Parkinson's disease: networks, models and treatments."), published in Trends Neurosci.30, 2007, pages 357 to 364; N. Weisz, S. Moratti, M. Meinzer, K. "Tinnitus Perception and Di stress Is Related to Abnormal Spontaneous Brain Activity as Measured by Magnetoencephalography" by Dohrmann and T.Elbert In PLoS Med 2(6), 2005, pp. 546-553; J.J. Schulman, R. Cancro, S. Lowe, F. Lu, K.D. Walton, and R.R. Llinás "Pictures of Thalamic Rhythm Disorders in Neuropsychiatry" ("Imaging of Thalamocorti...
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Login to View More IPC IPC(8): A61B5/00A61N1/36
CPCA61B5/4094A61B5/04842A61N1/36025A61B5/4082A61B5/04845A61B5/0488A61B5/4064A61N1/3605A61B5/378A61B5/38A61B5/389A61N1/05A61B5/246A61B5/316A61B5/381A61B5/7246A61B2562/0214A61B5/291
Inventor 彼得·亚历山大·塔斯
Owner FORSCHUNGSZENTRUM JUELICH GMBH