Bambuterol Hydrochloride tablet composition

Abstract

The present invention relates to a bambuterol hydrochloride tablet composition, which comprises, by mass, 5-10% of bambuterol hydrochloride, 30-60% of lactose, 10-40% of starch, 10-30% of sodium carboxymethyl starch, 1-3% of talc powder, 0.2-0.8% of magnesium stearate, and 0.2-0.8% of sodium carboxymethyl cellulose. According to the present invention, the plasma half-life is about 17 h after the bambuterol hydrochloride tablet composition is subjected to oral administration, the plasma half-life of the active metabolite terbutaline is about 17 h, the effective action effect of the bambuterol hydrochloride tablet composition can achieve 24 h, the bambuterol hydrochloride tablet composition is only be taken once every night so as to achieve easy administration, the medical values are provided for asthma patients with easy attacking at night or on the morning and aggravation, and the bambuterol hydrochloride tablet composition is an ideal anti-asthmatic drug.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing organic active ingredients, in particular to a bambuterol hydrochloride tablet composition. Background technique [0002] Bambuterol Hydrochloride Tablet, chemical name: 1-[bis-(3',5'-N,N-dimethylcarbamoyloxy)phenyl]-2-N-tert-butyl Aminoethyl Ethanol Hydrochloride. This product is a selective β2 receptor agonist-the prodrug of terbutaline. After oral absorption, it is metabolized to terbutaline under the action of enzymes. Terbutaline mainly activates the β2 receptors of bronchial smooth muscle, thereby relaxing the bronchial smooth muscle. The indications are bronchial asthma, chronic asthmatic bronchitis, obstructive emphysema and other lung diseases accompanied by bronchospasm. [0003] Babuterol hydrochloride is a new generation of long-acting β2 adrenoceptor agonist, and it is the substitute of terbutaline (terbutaline) (trade name: Bricanyl), an anti-asthma drug widely used in cl...

AI Technical Summary

Problems solved by technology

In the prior art, improper selection of binders, improper water content of raw and auxiliary materials, and excessive use of lubricants will cause the extension of the disintegration time limit

[0005] At present, there are many anti-asthma drugs widely used clinically in China, such as ephedrine, isoproterenol, albuterol, terbutaline, fenoterol, tulobuterol, procaterol, clenbuterol, etc., although these The curative effect of the drug is certain, but the half-life is relatively short, and it often needs to be administered 3-4 times a day, or even 5-6 times, which brings great inconvenience to the patient.

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