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Long-acting terramycin injection and preparation method thereof

A long-acting oxytetracycline and injection technology, applied in pharmaceutical formulations, tetracycline active ingredients, antibacterial drugs, etc., can solve the problems of incomplete absorption of oxytetracycline alkali, high price, easy oxidation, etc., to improve the scope of use , low cost, high cost performance

Inactive Publication Date: 2015-07-29
TIANJIN JIACHUANG BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Oxytetracycline belongs to tetracycline antibiotics, which is produced by Streptomyces rimosus. The normal salt appears in the form of acid salt. It is the most widely used antibiotic in animals. It is cheap and is used as a basic medicine for livestock and poultry health. It is usually added to feed Oxytetracycline base or in the form of injection, its global consumption ranks first every year. Oxytetracycline base cannot be completely absorbed orally, and contains more compounds, so it is not used. Oxytetracycline injection is widely used now. It was first introduced by the United States Pfzer Company was the first to develop Oxytetracycline Injection. Its name is Demixian. It is mainly used to treat respiratory, intestinal, and gastrointestinal infections caused by mycoplasma, bacteria, and chlamydia in animals. It has also been included in the national quality standard. , the price of oxytetracycline injection imported from abroad is very high, and many large-scale breeding factories dare not use it, especially when the market conditions are not optimistic.
The domestic oxytetracycline injection has short drug effect, is unstable, and is easy to oxidize, change color and precipitate

Method used

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  • Long-acting terramycin injection and preparation method thereof
  • Long-acting terramycin injection and preparation method thereof
  • Long-acting terramycin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A long-acting oxytetracycline injection, the components and weights of which are included in the injection are: oxytetracycline 10g, dimethylformamide 10g, ethanolamine 5g, propylene glycol 10g, sodium formaldehyde sulfoxylate 1g, absolute ethanol 20g, Tween-80 10g, sustained-release preparation 1g, water for injection 1g.

[0025] A long-acting oxytetracycline injection and a preparation method thereof, the steps of the preparation method are as follows:

[0026] (1) Weigh oxytetracycline, dimethylformamide, and ethanolamine respectively according to the weight ratio, dissolve oxytetracycline in dimethylformamide, stir continuously, and then slowly add ethanolamine until the brownish-red is translucent, and obtain A liquid, spare;

[0027] (2) Weigh the water for injection, sustained-release agent, and sodium formaldehyde sulfoxylate respectively according to the weight ratio, add the sustained-release agent and sodium formaldehyde sulfoxylate into the water for injec...

Embodiment 2

[0031] A long-acting oxytetracycline injection, the components and weights of which are included in the injection are: oxytetracycline 40g, dimethylformamide 40g, ethanolamine 10g, propylene glycol 30g, sodium formaldehyde sulfoxylate 2g, absolute ethanol 30g, Tween-8020g, sustained-release preparation 8g, water for injection 5g.

[0032] The steps of its preparation method are the same as in Example 1.

Embodiment 3

[0034] A long-acting oxytetracycline injection, the components and weights of which are included in the injection are: oxytetracycline 30g, dimethylformamide 15g, ethanolamine 5g, propylene glycol 15g, sodium formaldehyde sulfoxylate 1g, absolute ethanol 20g, Tween-8010g, sustained-release preparation 7g, water for injection 3g.

[0035] The steps of its preparation method are the same as in Example 1.

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Abstract

The invention relates to a long-acting terramycin injection and a preparation method thereof. The injection comprises, by weight, 10-40 parts of terramycin, 10-40 parts of dimethyl formamide, 5-10 parts of ethanolamine, 10-30 parts of propylene glycol, 1-2 parts of sodium formaldehyde thiosulfate, 20-30 parts of anhydrous ethanol, 10-20 parts of tween-80, 1-8 parts of a sustained release agent and 1-5 parts of water for injection. The long-acting terramycin injection has the advantages of scientific compatibility, advanced technology, lasting drug effect, reasonable composition, wide effect and use safety, is a long-acting preparation with small irritation, and is mainly used for preventing and treating infections induced by Gram-negative bacteria, Gram-positive bacteria, spirochetes, actinomyces, mycoplasmas, rickettsiae and other protozoan.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a long-acting oxytetracycline injection and a preparation method thereof. Background technique [0002] Oxytetracycline belongs to tetracycline antibiotics, which is produced by Streptomyces rimosus. The normal salt appears in the form of acid salt. It is the most widely used antibiotic in animals. It is cheap and is used as a basic medicine for livestock and poultry health. It is usually added to feed Oxytetracycline base or in the form of injection, its global consumption ranks first every year. Oxytetracycline base cannot be completely absorbed orally, and contains more compounds, so it is not used. Oxytetracycline injection is widely used now. It was first introduced by the United States Pfzer Company was the first to develop Oxytetracycline Injection. Its name is Demixian. It is mainly used to treat respiratory, intestinal, and gastrointestinal infections caused by mycopla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/65A61K47/34A61P31/04A61P31/00
Inventor 陈庆忠安同伟曹桂敏
Owner TIANJIN JIACHUANG BIO TECH
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