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Application of traditional Chinese medicinal composition in preparation of rhinitis treatment medicines

A composition and technology of traditional Chinese medicine, applied in the application field of traditional Chinese medicine composition in the preparation of medicines for treating rhinitis, which can solve the problems of ineffectiveness and poor curative effect of rhinitis

Inactive Publication Date: 2015-08-12
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used in the treatment of rhinitis. These drugs have poor or ineffective effects on chronicity and recurrent rhinitis

Method used

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  • Application of traditional Chinese medicinal composition in preparation of rhinitis treatment medicines
  • Application of traditional Chinese medicinal composition in preparation of rhinitis treatment medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Take 15 parts of Celestia chinensis, 12 parts of maple lotus, 18 parts of Gymnema broadleaf, 10 parts of Zanthoxylum bungeanum leaf, 20 parts of a little red, add water and decoct twice, the amount of water added for the first time is 1 / 2 of the weight of medicinal materials 10 times the amount, decocted for 2 hours, the amount of water added for the second time was 8 times the weight of the medicinal materials, decocted for 1 hour, combined the decoction, concentrated, dried, and pulverized to obtain Chinese medicine composition granules. The concentration conditions were: 0.07MPa, 60 Concentrate under reduced pressure at -70°C to 65°C with a relative density of 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0015] Embodiment 2: The influence of traditional Chinese medicine composition of the present invention on ovalbumin-induced allergic rhinitis in rats

[0016] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0017] 2. Methods: Male SD rats, weighing 180-220 g, were intraperitoneally injected with 1 mg of ovalbumin and 10 mg of aluminum hydroxide gel, and then injected once every other day, a total of 7 times. From the 14th day, 10ul of 1mg / ml ovalbumin physiological saline solution was instilled into the nasal cavities of both sides of the rat every day, 7 times in total. Immediately after the last infusion, observe the number of times the rats sneeze and wipe their noses within 30 minutes, and the test drug is orally administered 1 hour before the last infusion of ovalbumin.

[0018] Table 1 The influence of traditional Chinese medicine composition of the present invention on ovalbumin-induced allergic rhinitis in rats (x±SD), n=7

[0019] ...

Embodiment 3

[0022] Embodiment 3, the influence of Chinese medicine composition of the present invention on the rat rhinitis that histamine causes

[0023] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0024] 2. Methods: Male SD rats, weighing 180-220g, were given the test drug orally, 10ul of 1M histamine saline solution was instilled into the nasal cavities on both sides one hour later, and the number of sneezing and nose rubbing of the rats was observed within 30 minutes.

[0025] Table 2 Chinese medicine composition of the present invention causes the influence of rat rhinitis to histamine (x ± SD) n=7

[0026]

[0027] Compared with the control group, **P<0.01*P<0.05

[0028] It can be seen from Table 2 that the traditional Chinese medicine composition of the present invention (4.8g crude drug amount / kg) obviously reduces the number of sneezing in rats with rhinitis caused by histamine, and tends to inhibit the response to scratching the nose. ...

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PUM

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Abstract

A traditional Chinese medicinal composition for treating immune inflammations is prepared from 15 parts of Ford Nervilia Leaf, 12 parts of root of Dentiferous Dendropanax, 18 parts of Gymnema latifolium, 10 parts of Zanthoxylum ailanthoides Sieb. et Zucc. and 20 parts of Sowthistleleaf Tasselflower. The composition is used for preparing immune inflammation treatment medicines, and is especially suitable for preparing rhinitis treatment medicines. Compared with terfenadine and diclofenac sodium, the traditional Chinese medicinal composition has the advantages of clear curative effect and marked progress.

Description

technical field [0001] The invention relates to the new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of medicine for treating rhinitis. Background technique [0002] Rhinitis is a common and frequently-occurring disease in clinical practice. The occurrence of rhinitis is mainly related to allergic reactions and belongs to the category of immune inflammation. At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used for the treatment of rhinitis, and these drugs have poor or ineffective effects on chronicity and recurrent rhinitis. Therefore, small molecular compounds with clear components, quality control, safety and high efficiency have potential value in the development of drugs for rhinitis treatment. Contents of the invention [0003] The object of the present invention is to provide an appl...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P11/02
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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