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Eutectic mixtures in personal care compositions

A eutectic mixture, personal care technology, applied in cosmetic formulations, cosmetic formulations, pharmaceutical formulations, etc., can solve problems such as damage to texture

Active Publication Date: 2015-09-16
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such recrystallization can cause undesired gelling of such personal care products, disrupting their texture

Method used

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  • Eutectic mixtures in personal care compositions
  • Eutectic mixtures in personal care compositions
  • Eutectic mixtures in personal care compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Using the ingredients in Table 1 and the amounts described in Tables 2A and 2B, a mixture of BMDM, IPM, and (if present) 12-HSA was prepared as follows.

[0098]The three components BMDM, IPM and 12-HSA were weighed and then mixed by grinding in a mortar and pestle until a homogeneous clear mixture was obtained.

[0099] Table 1. Composition of the ternary eutectic mixture

[0100] Element purity CAS# supplier Melting point (°C) 12-HSA 95% 106-14-9 Alfa Aesar 81.5 BMDM (Parsol 1789?) 99.5% 70356-09-1 DSM 84.8 IPM 99% 110-27-0 Sigma 8.9

[0101] The melting points of these mixtures were measured and the results are shown in Tables 2A and 2B. It is clearly shown that the particular mixture has a lower melting temperature. The lowest measured melting point of about 5.6°C was determined for eutectic compositions of BMDM, IPM and 12-HSA at a weight ratio of 1:9 and a 12-HSA concentration of 3.5 wt% (for the total weight o...

Embodiment 2

[0107] A personal care composition (A2) comprising a preformed mixture of butylmethoxydibenzoylmethane, isopropyl myristate and 12-hydroxystearic acid according to Table 3A was prepared using the following protocol:

[0108] 1. Prepare Phase A by mixing the ingredients and heating the mixture to 70°C to dissolve the ingredients.

[0109] 2. Prepare phase B by mixing sodium polyacrylate and 1,3-butanediol and adding it to phase A. Rinse the beaker with glycerin and decante the glycerin into phase A. Repeat the same operation with water.

[0110] 3. Prepare Phase C by mixing ingredients at 75°C with hand stirring until phase is clear.

[0111] 4. Prepare Phase D by mixing the ingredients of the eutectic mixture (ie, BMDM, IPM, and 12-HSA) in a mortar and pestle until a clear liquid is obtained. Add this liquid to phase C.

[0112] 5. Mix the ingredients of phases E and F separately and add to the mixture obtained after step 4) at 75 °C with manual stirring.

[0113] 6. Add ...

Embodiment 3

[0121] Personal care compositions according to Table 3B were prepared using the following protocol. In A1, butylmethoxydibenzoylmethane, isopropyl myristate, and 12-hydroxystearic acid were added separately (ie not added as a pre-made eutectic mixture). A3 contains butylmethoxydibenzoylmethane and 12-hydroxystearic acid, but no isopropyl myristate.

[0122] 1. Prepare Phase A by mixing the ingredients and heating the mixture to 70°C to dissolve the ingredients.

[0123] 2. Prepare phase B by mixing sodium polyacrylate and 1,3-butanediol and adding it to phase A. Rinse the beaker with glycerin and decant to phase A. Repeat the same operation with water.

[0124] 3. Prepare Phase C by mixing ingredients at 75°C with hand stirring until phase is clear. For Al, 12-HSA and isopropyl myristate were added one by one to the dispersion as the last ingredients. In A3, 12-HSA was added to the dispersion as the last ingredient, this phase did not contain isopropyl myristate.

[0125...

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Abstract

The invention relates to active eutectic mixtures of butyl methoxydibenzoylmethane, isopropyl myristate and optionally 12-hydroxystearic acid, personal care products comprising such active eutectic mixtures, a method for preparing such personal care compositions and a method of applying to human skin such personal care compositions.

Description

field of invention [0001] The present invention relates to eutectic mixtures of butylmethoxydibenzoylmethane, isopropyl myristate, and optionally 12-hydroxystearic acid; and personal care compositions comprising such eutectic mixtures. Background of the invention [0002] 12-Hydroxystearic acid (hereinafter "12-HSA") is reported to have various beneficial cosmetic effects on the skin. It is a known PPAR-alpha (peroxisome proliferator-activated receptor alpha subtype) activator, skin lightening agent and sebum secretion inhibitor. See for example US 6,423,325 to Alaluf et al, US 6,713,051 to Mayes et al, WO 2006 / 056283 (Hindustan Lever), US 2009 / 0317341 to Madison, US 6,197,343 to Minami et al, US2004 / 0043044 by Granger et al. [0003] Therefore, cosmetic products containing 12-HSA are highly desirable. [0004] JP 09-048962 describes the use of 12-HSA or a salt thereof as an active ingredient of a coagulation inhibitor to inhibit coagulation of liquid cleansers or liquid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/35A61K8/365A61K8/37
Inventor E.克霍斯德S.G.舒姆姚银芳张启清
Owner UNILEVER IP HLDG BV
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