Composition of gamma-aminobutyric acid and chitosan oligosaccharide, as well as preparation method and applications of composition

A technology of aminobutyric acid and chitosan oligosaccharides, which is applied in application, food preparation, drug combination, etc., can solve the problem of single mechanism of action of γ-aminobutyric acid, weak blood lipids, and lack of protective functions against cardiovascular and cerebrovascular diseases And other issues

Active Publication Date: 2015-09-23
云康大健康产业(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the disadvantage is that the mechanism of γ-aminobutyric acid in cerebrovascular is relatively simple, and it lacks comprehensive protection of cardiovascular and

Method used

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  • Composition of gamma-aminobutyric acid and chitosan oligosaccharide, as well as preparation method and applications of composition
  • Composition of gamma-aminobutyric acid and chitosan oligosaccharide, as well as preparation method and applications of composition
  • Composition of gamma-aminobutyric acid and chitosan oligosaccharide, as well as preparation method and applications of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0316] Example 1. Compound tablets of gamma-aminobutyric acid and oligochitosan and their preparation

[0317] The prescription quantity is calculated by weight percentage and contains:

[0318] γ-aminobutyric acid 20%-50%, preferably 40%,

[0319] Chitooligosaccharides 20%-50%, preferably 40%,

[0320] Mannitol 10%-40%, preferably 12%,

[0321] Sodium carboxymethyl starch 1%-10%, preferably 5%,

[0322] Hydroxypropyl cellulose aqueous solution appropriate amount, preferably 2.5% hydroxypropyl cellulose aqueous solution, 2% based on hydroxypropyl cellulose,

[0323] Magnesium stearate 0.5% to 2%, preferably 1%;

[0324] The preparation method includes: passing γ-aminobutyric acid, chitooligosaccharides, mannitol, and sodium carboxymethyl starch through an 80-mesh sieve, preferably 100-mesh. Mix the oligosaccharides evenly, add mannitol and sodium carboxymethyl starch, mix well, add hydroxypropyl cellulose aqueous solution to make a soft material, pass through a 24-mesh sieve to granulate,...

Embodiment 2

[0325] Example 2. Compound granules of gamma-aminobutyric acid and oligochitosan and their preparation

[0326] The prescription quantity is calculated by weight percentage and contains:

[0327] γ-aminobutyric acid 0.5%-20%, preferably 2.5%,

[0328] Chitooligosaccharides 0.5%-20%, preferably 3%,

[0329] Granule auxiliary material 60%~99%, preferably fructose 94.5%;

[0330] Wherein the granule auxiliary material includes one or more of the following ingredients: fructose, xylitol, oligofructose, polyfructose, xylo-oligosaccharide, polydextrose, mannitol, sucrose, invert sugar (ie glucose and fructose The same amount of mixture), glucose, resistant dextrin, sorbitol, maltose, isomalt, oligomannose, solid polyethylene glycol (such as polyethylene glycol-4000, polyethylene glycol-12000 , Polyethylene glycol-6000, polyethylene glycol-2000, etc.), dextrin, cyclodextrin, maltodextrin, hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, carboxymethyl cellulose, hydroxy Propylmethyl...

Embodiment 3

[0332] Example 3. Compound capsules of γ-aminobutyric acid and oligochitosan and preparation thereof

[0333] The prescription quantity is calculated by weight percentage and contains:

[0334] γ-aminobutyric acid 10%-45%, preferably 25%,

[0335] Chitooligosaccharides 15%-45%, preferably 25%,

[0336] Mannitol 15%-35%, preferably 28%,

[0337] Pregelatinized starch 8%-25%, preferably 15%,

[0338] Sodium carboxymethyl starch 1%-15%, preferably 5%,

[0339] Ethanol solution of polyvinylpyrrolidone is appropriate, preferably 1% polyvinylpyrrolidone,

[0340] Magnesium stearate 0.5% to 2%, preferably 1%;

[0341] The preparation method includes: passing γ-aminobutyric acid, chitooligosaccharides, mannitol, pregelatinized starch, and sodium carboxymethyl starch through an 80-mesh sieve, preferably a 100-mesh sieve. Gamma-aminobutyric acid and chitosan oligosaccharides are evenly mixed to obtain mixed powder A, which is ready to be used; in addition, mannitol, pregelatinized starch, and sodium...

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Abstract

The invention provides a drug composition containing gamma-aminobutyric acid and chitosan oligosaccharide; the dosage form of a drug can be any pharmaceutically acceptable drug dosage form; the gamma-aminobutyric acid and the chitosan oligosaccharide are combined according to the weight ratio of (0.1 to 5):1. The invention further provides a preparation method of the composition, and applications of the composition to preparation of a drug for reducing blood pressure, protecting heart and cerebral vessels or treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a health product composition, its preparation method and application, in particular to the composition of gamma-aminobutyric acid and chitosan oligosaccharide, its preparation method and application. The health product composition of the present invention includes but not limited to medicine, medical food, health food or functional food, common food and so on. Background technique [0002] γ-Aminobutyric acid (GABA) is a natural active ingredient, a non-protein amino acid widely distributed in animals and plants, and plays an irreplaceable role in the regulation of organism life activities; Inhibitory neurotransmitter, it participates in a variety of metabolic activities and has high physiological activity. In terms of cerebrovascular and cranial nerves, it can promote energy metabolism of the brain, activate cerebral blood flow, increase oxygen supply, nourish nerve cells, enhance Brain vitality, restoration of brain cell fun...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K9/20A61K9/48A61K9/16A61P9/12A61P9/00A23L1/09A61K31/197
Inventor 张耿元王保红白东跃
Owner 云康大健康产业(广州)有限公司
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