A kind of preparation method of traditional Chinese medicine pill for treating tuberculosis
A technology for traditional Chinese medicine pills and tuberculosis, which is applied in the field of medicine, can solve the problems of high control cost, low release rate of active ingredients, long time limit for dissolution and the like, and achieves the effects of reducing energy consumption, shortening production cycle and reducing production cost.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0025] A preparation method of a traditional Chinese medicine pill for treating tuberculosis, specifically through the following processes:
[0026] 1) Tuberculosis pill prescription:
[0027] 150g vinegar tortoise shell, 150g honey beetle, 100g vinegar turtle shell, 50g calcined amethyst, 100g rehmannia glutinosa, 100g rehmannia glutinosa, 50g asparagus, 100g ginseng, 100g oyster, 100g donkey-hide gelatin, 50g keel, 50g radishes, 100g beeswax , cooked rhubarb 25g, white and 100g, Chuan Fritillaria 100g. Excipients: activated carbon 10g, Sichuan wax 0.84g, sucrose 10g, talcum powder 20g.
[0028] 2) Processing of medicinal materials:
[0029] Tortoise shell: put the sand in the pot, heat it with strong fire until the sand is smooth and smooth, and when it is easy to turn, put in clean tortoise shells in grades of different sizes, fry until the quality is crisp, the surface is light yellow, take out the sieve to remove the sand, put it into the vinegar liquid for a while whil...
Embodiment 2
[0041] Embodiment 2 in vitro anti-tuberculosis experiment
[0042]1) Experimental materials:
[0043] ①Drugs: Experimental group: tuberculosis pills prepared in Example 1; control group: tuberculosis pills (honeyed pills) containing crude drug 0.56 / g, prepared by Gansu Tianshui Qihuang Pharmaceutical Co., Ltd., rifampicin purchased from Lanzhou Jiuzhoutong Pharmaceutical Company ( Shanghai Xinyi Vientiane Pharmaceutical Co., Ltd.).
[0044] ② Animals: 210-220 mice of Kunming species, half male and half male, provided by School of Pharmacy, Lanzhou University.
[0045] ③Strains: Mycobacterium tuberculosis H37RV (Yycobaclercum tuberc-ulosis~H37RV) and Mycobacterium hominis were introduced from Gansu Provincial Institute of Tuberculosis Prevention and Control. They were passaged on the slant of Roche chicken eggs and cultured at 37°C for two weeks for the test.
[0046] 2) Test method:
[0047] ①Minimum Inhibitory Concentration (MIC): Soak the experimental group and the contro...
Embodiment 3
[0068] Embodiment 3 animal acute toxicity test
[0069] 1) Experimental materials:
[0070] ①Drugs and reagents: The tuberculosis pills prepared in Example 1 were provided by Gansu Tianshui Qihuang Pharmaceutical Co., Ltd., and the medicines were ground and added with distilled water to form a 40% suspension for animal experiments.
[0071] ② Animals: Kunming mice, both male and female, 20±2g, provided by Lanzhou Medical College.
[0072] 2) Method:
[0073] Acute toxicity test: 30 Kunming mice of 20 ± 2g, half male and half male, after fasting for 12 hours, ig 40% tuberculosis pill suspension 35ml / kg (maximum concentration, maximum capacity) once in the morning and once in the afternoon, continuously Observation for 7 days.
[0074] 3) Results:
[0075] Mice were administered twice a day, and the total dosage was 35g crude drug / kg.d. After 7 days of observation, there was no abnormal behavior and no symptoms of poisoning; the mice ate, feces, and fur were normal, and the...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More