Human stem cell growth factor injection and preparation method thereof

A technology for injection and water for injection, applied in the field of medicine and biology, can solve the problems of loss of protein activity and lack of visibility, and achieve the effect of reducing the dosage, stable product quality, and suitable for large-scale production and application.

Active Publication Date: 2015-09-23
GUANGZHOU JINAN BIOMEDICINE RES & DEV CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For protein drugs, complex processes and severe conditions may lead to loss of protein activity
At present, there is no injection with the nucleotide sequence shown in SEQ ID NO.1 in the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 1000mL of water for injection, adjust the pH to 5.5 with citrate, add 40g of human serum albumin, stir to obtain a solution, then take 20mg of the nucleotide sequence shown in SEQ ID NO.1 and add it to the solution, add PEG400 to 15% ( w / v), stir and mix evenly, place at 3°C ​​for 10 hours, add sodium chloride to make the ionic strength of the solution at 0.2 mol / L, and then adjust the pH to 5.5 with citrate to obtain an injection.

Embodiment 2

[0018] Take 1000mL of water for injection, adjust the pH to 5.5 with citrate, add 40g of human serum albumin, stir to obtain a solution, then take 20mg of the nucleotide sequence shown in SEQ ID NO.1 and add it to the solution, add PEG600 to 15% ( w / v), stir and mix evenly, place at 3°C ​​for 10 hours, add sodium chloride to make the ionic strength of the solution at 0.2 mol / L, and then adjust the pH to 5.5 with citrate to obtain an injection.

Embodiment 3

[0020] Take 1000mL of water for injection, adjust the pH to 5.5 with citrate, add 40g of human serum albumin, stir to obtain a solution, then take 20mg of the nucleotide sequence shown in SEQ ID NO.1 and add it to the solution, add PEG800 to 15% ( w / v), stir and mix evenly, place at 3°C ​​for 10 hours, add sodium chloride to make the ionic strength of the solution at 0.2 mol / L, and then adjust the pH to 5.5 with citrate to obtain an injection.

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PUM

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Abstract

The invention relates to a human stem cell growth factor injection and a preparation method thereof. The injection can realize a slow-release technical effect, can reduce the medicine taking times of a patient, can improve the compliance, can be used for preparation of drugs for anemia treating, reconstruction and recovery of the hematopoietic function after chemoradiotherapy and bone marrow transplantation, drugs for stem cells in vitro amplification and gene therapy drugs, and can be applied to the field of cosmetics for promoting skin cell metabolism, repairing aging and damaged skin cells, delaying skin aging and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to an injection of human stem cell growth factor. Background technique [0002] Stem cell growth factor (SCGF) is an acidic glycoprotein produced by stromal cells in the bone marrow microenvironment. It is an important hematopoietic cytokine that mainly acts on early hematopoietic stem cells and primitive hematopoietic progenitor cells, promoting their proliferation and Differentiation plays an important role in maintaining the survival of hematopoietic cells, promoting the proliferation and differentiation of hematopoietic cells, and regulating the growth and development of various hematopoietic cells. With the deepening of research, it is found that human stem cell growth factor has a variety of biological functions and can be widely used in many fields such as biomedicine and fine chemical industry. Especially in recent years, the rapid development of st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K38/19A61K47/34A61K47/42A61P7/00
Inventor 王一飞王巧利任哲
Owner GUANGZHOU JINAN BIOMEDICINE RES & DEV CENT
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