Nutritional composition with non digestible oligosaccharides

A technology of non-digestible oligosaccharides and nutritional compositions, which is applied in the field of nutrients and can solve problems such as lack of villi height

Inactive Publication Date: 2015-10-07
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Shim et al., 2005, Acta Agriculturee Scandinavica, 55:91-97 found no such effect on villus height of the small intestine when two different concentrations of fructo-oligosaccharides were tested in piglets

Method used

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  • Nutritional composition with non digestible oligosaccharides
  • Nutritional composition with non digestible oligosaccharides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Infant formula containing non-digestible oligosaccharides increases intestinal volume in piglets

[0049] Eighteen age- and weight-matched (Piétrain X (Large White X Landrace)) male piglets (mean BW 5.1 ± 0.03 kg) were selected from 8 different litters at 14 days postnatal. Piglets were placed individually in a temperature-controlled room maintained at 28°C. On day 26, after an overnight fast, piglets were T-cannulated distal to the terminal ileum. Piglets were allowed to recover for 7 days before the start of the experiment. Six diets were tested in piglets. The diet was dissolved in demineralized water (37°C) to a final dry matter content of 20% (w / v).

[0050] Diet 1 was an infant formula comprising short-chain trans-galactooligosaccharides GOS2 (β linkages, mainly β1,3 linkages) at a concentration of 1.0% by weight, 0.2 g / 100 ml, based on the dry weight of the total composition. The osmolality of the formula is 453±2.4mOsm / kg.

[0051] Diet 2 was inf...

Embodiment 2

[0075] Every 100 milliliters of infant formula composition contains following ready-to-eat formula: 1.6g protein, 3.6g fat, 6.4g digestible carbohydrate (mainly lactose), 0.8g non-digestible oligosaccharide (wherein 0.72g is trans-semi milk oligosaccharide), 0.08g inulin. The packaging and / or supporting material accompanying the product indicates that the product is suitable for reducing luminal proteases in the intestine, or preventing bacterial overgrowth in the small intestine, or increasing gastrointestinal transit time or reducing the activity of toxins in the intestine.

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Abstract

The present invention relates to the use of non digestible oligosaccharides above a certain threshold for improving health of the small intestine, in particular in infants and small children, by increasing the luminal fluid volume and reducing the protease activity or density.

Description

technical field [0001] The present invention relates to a nutrient for infants, in particular an infant formula, comprising non-digestible oligosaccharides for improving the intestinal health of an infant or young child, in particular for improving the health of the small intestine. Background technique [0002] Breastfeeding is the preferred method of feeding babies. However, there are also situations where breastfeeding is not possible or desired. In these cases, infant formula is a good alternative. The composition of modern infant formulas is adjusted to meet the many specific nutritional needs of rapidly growing and developing infants. Further improvements can still be made. [0003] Human milk contains non-digestible oligosaccharides, which represent the third largest group after lactose and lipids. Depending on the mother's Lewis blood group and lactation period, the concentration of non-digestible oligosaccharides in mature human milk can be about 7.5 to 15 g / L....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/308A23L1/29A61K31/702A23L33/00
CPCA23L1/308A23L1/296A61K31/702A23L33/40A23L33/21A23V2002/00
Inventor S·休伯斯T·路德维格H·鲍里迪尤斯
Owner NV NUTRICIA
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