Multifunctional drug combination and preparation method and application thereof

A multi-functional and pharmaceutical technology, applied in the direction of drug combination, pharmaceutical formula, heterocyclic compound active ingredients, etc., can solve the problems of difficult treatment, unsatisfactory treatment effect, easy disease, etc., to reduce the dosage of drugs, reduce the side effects of drugs, The effect of high-efficiency synergy

Inactive Publication Date: 2015-10-21
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under the influence of the body of the mother animal, especially the abnormality of the udder, and the environment, the young animals with weaker physique are prone to the disease, and once the disease occurs, it is often difficult to treat or the treatment effect is not satisfactory
The reason is that young animals are born shortly after birth, have weak resistance, acute onset and a short course of disease. The use of existing traditional medicines for treatment often requires compulsory measures such as injection or gavage due to the single function and poor palatability of the medicine. drug, repeat
Therefore, the effect of the drug is not timely or the young animal is frightened to produce a stress response, etc., which greatly reduces the therapeutic effect of the young animal disease

Method used

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  • Multifunctional drug combination and preparation method and application thereof
  • Multifunctional drug combination and preparation method and application thereof
  • Multifunctional drug combination and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The type, dosage and combination of auxiliary materials are important factors of the preparation, which are directly related to whether the preparation can be obtained and the quality of the preparation obtained. For the present invention, the most important inspection indexes are palatability and disintegration speed. In order to prepare orally rapidly disintegrating tablets with good palatability and fast disintegration speed, the formulation of the present invention is screened.

[0057] Preparation of different formulated products

[0058] According to the following formula and process to prepare different multi-functional zaijieding respectively.

[0059] Formulation: See Table 1.

[0060] Table 1 Design schemes of different formula ratios

[0061]

[0062] Process: Take MCC, L-HPC, SDS, SB, sodium glycyrrhizinate and fresh milk essence, mix them evenly, pulverize them, pass through a 200-mesh sieve, and use them as material A; take atropine sulfate, amvaloxa...

Embodiment 2

[0064]Take 9kg of microcrystalline cellulose (MCC), 2.1kg of low-substituted hydroxypropyl cellulose (L-HPC), 0.1kg of sodium dodecylsulfonate (SDS), 0.2kg of sodium hydroxypropylbutylate (SB), and sodium glycyrrhizinate 0.05kg and fresh milk essence 0.05kg, mix well, pulverize, pass through 200 mesh sieve, it is A material; take atropine sulfate 0.05kg, amvaloxetamine sulfate 0.3kg, sodium glutamate (MSG) 0.15kg, potassium chloride Dissolve 0.1kg in 10kg of water, add 10kg of sucrose, mix, heat to make a paste; add 4kg of norfloxacin nicotinate, 6.7kg of glucuronate and 4kg of material A while hot, mix well, and make a soft material; 60-mesh fine granules; add 0.2kg of magnesium stearate, mix evenly, and spheronize on a spheronizer to prepare round granules; dry; add 67kg of mannitol and the remaining material A, mix evenly, and press into 100,000 tablets.

Embodiment 3

[0066] Take 16kg of MCC, 3.2kg of L-HPC, 0.3kg of SDS, 0.4kg of SB, 0.2kg of sodium glycyrrhizinate and 0.2kg of fresh milk essence, mix them evenly, pulverize them, pass through a 200-mesh sieve, and use them as material A; take 0.1kg of atropine sulfate, Dissolve 0.1kg of amphetamine sulfate, 0.8kg of MSG, and 0.3kg of potassium chloride in 10kg of water, add 18kg of sucrose, mix, and heat to make a paste; while hot, add norfloxacin niacin 6kg, glucuronate 4.6kg Mix with 4kg of material A to make a soft material; make 60 mesh fine particles; add 0.8kg of magnesium stearate, mix evenly, and spheronize on a spheronizer to make round granules; dry; add 49kg of mannitol and the remaining A Materials, mixed, pressed into 100,000 pieces.

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Abstract

The invention provides a multifunctional drug for treating diarrhea of young animals. The drug comprises 2-10 parts of norfloxacin nicotinate, 0.5-7.6 parts of glucurolactone, 0.02-0.48 part of atropine sulfate and 0.02-0.5 part of dimevamide. Preferentially, the drug further comprises 16-80 parts of mannitol, 5-30 parts of saccharose, 0.05-2 parts of sodium glutamate, 0.05-0.6 part of potassium chloride, 0.1-0.8 part of hydroxypropyl butyl ester sodium, 0.05-1.8 part of magnesium stearate, 0.01-0.6 part of sodium glycyrrhizinate, 0.01-0.5 part of fresh milk essence, 4-30 parts of microcrystalline cellulose, 0.6-6 parts of low-substituted hydroxypropyl cellulose and 0.01-0.7 part of sodium dodecyl sulfate. The invention further discloses a preparation method of the drug and the application of the drug in treating diarrhea of the young animals. The drug can achieve the effects of detoxication, sterilization and diarrhea checking; the constituents of the drug can achieve an efficient synergistic effect, so that the dosage of the drug is reduced, and the side effects of the drug are significantly reduced; the young animals can take the drug actively, and stress response is avoided; the drug can be released in a short time, and the drug is quite easy to absorb.

Description

technical field [0001] The invention belongs to the field of treatment of diarrhea in young animals, and in particular relates to a multifunctional medicine combination and its preparation method and application, and more particularly relates to a multifunctional medicine for diarrhea in young animals and its preparation method and application. Background technique [0002] Whether it is in animal husbandry or in pet breeding, the disease prevention and treatment of young animals has always been a difficult problem. Since the young animals are just born, the body has not had time to respond to immunity through vaccination. Therefore, the young animals are not only threatened by pathogens in the environment, but the mother animal is also a source of disease for the young animals while providing breast milk. Under the influence of the mother animal's body, especially the abnormality of the udder, and the environment, the young animals with weaker physique are prone to the dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/496A61K31/46A61K31/137A61K47/10A61K47/26A61K47/02A61K47/14A61K47/12A61K47/38A61K47/20A61P1/12
Inventor 丁晓刚李犹平吴学渊
Owner CHENGDU QIANKUN VETERINARY PHARMA
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