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A kind of manufacture technology of pullulan polysaccharide hollow capsule

The technology of pullulan polysaccharide and hollow capsule is applied in the field of making medicinal hollow capsules, which can solve the problems such as the reaction between gelling agent and capsule contents, decrease in production efficiency, influence on the concentration of glue liquid, etc., so as to increase convenience and improve The effect of improving production efficiency and drying speed

Active Publication Date: 2018-01-02
陕西嘉元生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the gel agent is generally a high-viscosity colloid, which seriously affects the concentration of the glue solution, resulting in a decrease in production efficiency
There are many types of gelling agents, and the types of capsule contents are even larger. The gelling agent and capsule contents may react, causing potential safety risks

Method used

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  • A kind of manufacture technology of pullulan polysaccharide hollow capsule
  • A kind of manufacture technology of pullulan polysaccharide hollow capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 20 kg and have a viscosity of 50mm 2 / s pullulan polysaccharide, add 60 kg of deionized water with a temperature of 60 degrees Celsius, stir and let it stand to form a uniform glue solution with a concentration of 25% by weight, use a mold with a temperature of minus 14 degrees Celsius to dip the glue, use minus 10 Celsius for drying. The sample obtained is Example 1.

[0028] After actual measurement, the thickness of the pullulan capsules conforms to the thickness of the pullulan capsules. Because there is no pullulan standard in China, the test is carried out according to the standard of gelatin hollow capsules in the "Chinese Pharmacopoeia", and all meet the requirements.

Embodiment 2

[0030] Weighing 20 kg, the viscosity is 180mm 2 / s of pullulan, add 80 kilograms of temperature and be 60 degrees Celsius of degassing water, stir and let it stand, and be configured into a 20% pullulan solution with a weight ratio concentration.

[0031] Set the mold dipping glue at minus 35 degrees Celsius. When controlling the thickness of the hollow capsule, adjust it according to the thickness of the hollow capsule between minus 30 degrees Celsius and 40 degrees Celsius. Dry at minus 20 degrees Celsius. The obtained sample is example 2. According to the standard test, all meet the requirements.

Embodiment 3

[0033] Weigh 20 kg Weigh 20 kg Viscosity is 100mm 2 / s of pullulan polysaccharide, add 60 kg of deionized water at a temperature of 40 degrees Celsius, stir and let it stand to form a uniform glue solution with a concentration of 25% by weight, dip it in a mold with a temperature of minus 5 degrees Celsius, and use Set the temperature at minus 30 degrees Celsius for drying. According to the requirements of the capsule, the thickness is adjusted between minus 20 degrees Celsius and minus 40 degrees Celsius. The obtained sample is Example 3, which is tested according to the standard and meets the requirements.

[0034] Compared with Example 1, the concentration of the solution is exactly the same. Although the mold temperature is increased, the drying temperature is lower, which successfully offsets the heating effect of the pullulan solution on the mold, and can also produce pullulan that meets the standard. Empty capsule product.

[0035] At the same time, we concluded that ...

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Abstract

The invention relates to a process for manufacturing pullulan hollow capsules. The process is characterized by comprising process steps of 1), selecting pullulan with the viscosity of 3-15 centipoise, adding the pullulan into hot water with the temperature of 40-80 Celsius degrees to prepare pullulan liquor with the weight concentration of 20-25%, uniformly stirring the pullulan liquor, preserving heat of the pullulan liquor, allowing the pullulan liquor to stand still and removing bubble; 2), arranging the prepared pullulan liquor in glue tanks of hollow capsule production lines, and dipping glue under the condition that the temperatures of molds range from minus 40 Celsius degrees to 0 Celsius degree under the control; 3), regulating the temperature of setting wind within intervals ranging from minus 40 Celsius degrees to 0 Celsius degree so as to prevent membranes formed by the pullulan liquor from flowing on the molds until the shapes of the membranes are fixed; 4), drying, cutting and sleeving the membranes and warehousing finished products. The process has the advantages that gel is omitted in production procedures, and accordingly the process is high in safety, drying speed and production efficiency.

Description

technical field [0001] The invention relates to a manufacturing process of pullulan hollow capsules, belonging to the technical field of medicinal hollow capsules. Background technique [0002] Empty gelatin capsule (Empty capsule): It is composed of a cap and a body made of medicinal gelatin and excipients. Mainly used to contain solid medicine. For example, self-made powders, health care products, medicines, etc., have solved the problems of difficulty in mouthfeeling and poor taste for users, and truly realized that good medicine is no longer bitter. Hollow capsules are becoming more and more popular. First of all, capsules are slender in shape and easy to swallow, making them the most popular dosage form for consumers. In addition, capsules can effectively cover up the unpleasant taste and smell of the contents. Capsules come in a variety of sizes, including size 00 extended, size 00, size 0, size 1, size 2, size 3, size 4 and size 5 capsules. Capsules can also be pri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 刘百平
Owner 陕西嘉元生物工程有限公司