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New application of traditional Chinese medicine composition to preparation of drugs for preventing and treating chronic obstructive pulmonary diseases

A technology for chronic obstructive pulmonary disease and composition, which can be applied in drug combinations, respiratory diseases, pharmaceutical formulations, etc., can solve the problems of different pathogenesis, slow progress in drug treatment research, and difficulty in obtaining satisfactory curative effects.

Inactive Publication Date: 2015-11-18
杨根西
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no drug that can curb the progressive development of COPD, and the research progress of its drug treatment is quite slow. At present, the drug for treating asthma is often used in clinical practice to treat COPD. Because the pathogenesis of COPD is different from that of asthma, it is difficult to obtain satisfactory curative effect.

Method used

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  • New application of traditional Chinese medicine composition to preparation of drugs for preventing and treating chronic obstructive pulmonary diseases
  • New application of traditional Chinese medicine composition to preparation of drugs for preventing and treating chronic obstructive pulmonary diseases
  • New application of traditional Chinese medicine composition to preparation of drugs for preventing and treating chronic obstructive pulmonary diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Take 20g of milk firewood, 18g of Amomum sativa, 15g of fenugreek, 12g of fat pig seedlings, 16g of xanthus sorbifolia, 18g of seabuckthorn beans, 12g of Xiaoluo umbrella, and 20g of centipede grass, add water to decoct 2 times, add water for the first time The amount of water is 10 times of the weight of the medicinal materials, decocted for 2 hours, the second time of adding water is 8 times of the weight of the medicinal materials, decocted for 1 hour, combined the decoction, concentrated, dried, and pulverized to obtain the traditional Chinese medicine composition granules. The concentration conditions are: : 0.07MPa, concentrated under reduced pressure at 60-70°C to 65°C, the relative density is 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0018] Embodiment 2: Pharmacodynamics experiment of the present invention

[0019] 1. Test drugs and materials: Prepare test drugs according to the method in Example 1 above. SPF grade female BALB / c mice, 18-20g, were randomly divided into normal control group, model control group, positive control group (terbutaline, 10mg / kg, intragastric administration), drug treatment group (traditional Chinese medicine composition 5, 10, 20 g crude drug amount / kg, intragastric administration), 10 rats in each group. The mice were placed in a 4L container and smoked every day (Jinjian brand cigarettes, tar content less than 16mg), five times a week, for four consecutive weeks, administered by intragastric administration 1 hour before the daily smoke. One hour after fumigation, anesthetize with sodium phenobarbital, perfuse the lungs with 0.6 mL of pre-cooled PBS buffer (pH 7.0), rinse 3 times, suck out the bronchoalveolar lavage fluid (BALF), and centrifuge at 250×g for 10 min , the super...

Embodiment 3

[0031] Example 3: Inhibitory effect of traditional Chinese medicine composition on the recruitment of inflammatory cells in the BALF of COPD mice

[0032] 1. Test drugs and materials: Prepare test drugs according to the method in Example 1 above.

[0033] 2. The inhibitory effect of traditional Chinese medicine composition on the recruitment of total inflammatory cells in the BALF of COPD mice: COPD is characterized by chronic inflammation throughout the airway, lung parenchyma and pulmonary blood vessels, which is manifested by neutrophils, T lymphocytes and macrophages increased in the lungs. Activated inflammatory cells release a series of inflammatory mediators, including LTB4, IL-8, TNFα, and others that can damage lung structures or maintain neutrophil inflammation. The purpose of this experiment is to investigate the effect of the traditional Chinese medicine composition on the recruitment of total inflammatory cells in the BALF of COPD mice. The results are shown in T...

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Abstract

The invention discloses new application of a traditional Chinese medicine composition to the preparation of drugs for preventing and treating chronic obstructive pulmonary diseases. The traditional Chinese medicine composition is prepared from the following materials: 20 parts of ficus lyrata, 18 parts of alpinia zerumbet, 15 parts of clinopodium polycephalum, 12 parts of herb of oldham groundsel, 16 parts of shinyleaf yellowhorn, 18 parts of oxytropis psammocharis, 12 parts of ardisia crassinervosa and 20 parts of nephrolepis cordifolia. The application of the traditional Chinese medicine composition to the preparation of drugs for treating chronic obstructive pulmonary diseases is disclosed for the first time, which is a great progress.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine composition, in particular to an application of the traditional Chinese medicine composition in preparing medicine for treating chronic obstructive pulmonary disease. Background technique [0002] Chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) is a common chronic disease worldwide, currently ranking fourth in the global cause of death, according to the World Health Organization forecast, by 2020, COPD will rank fifth in the incidence of global diseases , ranking third among the causes of death. COPD is a disease characterized by not fully reversible airflow limitation associated with an abnormal inflammatory response of the lungs to noxious gases or noxious particles, with chronic inflammation throughout the airways, lung parenchyma, and pulmonary vessels. The cells involved in COPD include inflammatory cells such as neutrophils, T lymph...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P11/00
Inventor 杨根西
Owner 杨根西
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