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Lanthanum coordination polymer, preparation method therefor and application thereof in catalyzing glycolide ring-opening polymerization

A technology of coordination polymer and ring-opening polymerization, applied in chemical instruments and methods, compounds containing elements of group 3/13 of the periodic table, organic chemistry, etc., to achieve good catalytic activity, good reproducibility, and easy operation Effect

Active Publication Date: 2015-11-18
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of lanthanide complexes to catalyze the ring-opening polymerization of glycolide to prepare high-molecular-weight PGA has not been reported in the literature.

Method used

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  • Lanthanum coordination polymer, preparation method therefor and application thereof in catalyzing glycolide ring-opening polymerization
  • Lanthanum coordination polymer, preparation method therefor and application thereof in catalyzing glycolide ring-opening polymerization
  • Lanthanum coordination polymer, preparation method therefor and application thereof in catalyzing glycolide ring-opening polymerization

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Experimental program
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Embodiment Construction

[0020] Preparation of experimental example 1 lanthanum coordination polymer:

[0021] 63.2 mg lanthanum acetate pentahydrate (0.2 mmol), 60.8 mg tetrachloroisophthalic acid (0.2 mmol), 16.0 mg sodium hydroxide (0.4 mmol), 3 mL ethanol, 1 mL water and 3 mL N,N-dimethyl The mixture of formamide was stirred at room temperature for 15 minutes, then transferred to a 15 mL stainless steel autoclave lined with tetrafluoroethylene, heated to 85 ° C for 24 hours, and then cooled to room temperature at a rate of 5 ° C per hour to obtain a colorless Blocky crystals, the crystals were washed with 5 mL of ethanol and 5 mL of ether, and dried naturally to obtain a lanthanum coordination polymer with a yield of 68%.

[0022] The main infrared absorption peak is (KBr / cm –1 ): 3527m, 3403br, 2983m, 2935m, 2848m, 1584s, 1446s, 1345s, 1326s, 1108w, 1056m, 1016s, 934m, 846w, 775s, 730s, 659s, 614s, 471m.

[0023] Experiment 1 Characterization of Lanthanum Coordination Polymers

[0024] (1) Str...

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Abstract

The present invention discloses a lanthanum coordination polymer, a preparation method therefor and an application thereof in catalyzing glycolide ring-opening polymerization, and relates to the field of polyglycolide catalysts. A chemical formula of the lanthanum coordination polymer is [La (m-BDC-Cl4) (OAc) (DMF)2(H2O)], wherein the m-BDC-Cl4 is a 2,4,5,6-tetrachloro-isophthalic acid dicarboxylic anionic ligand, the OAc is an acetate anion, and the DMF is N,N-dimethylformamide. The preparation method for the coordination polymer comprises: under a closed condition, the 2,4,5,6-tetrachloro-isophthalic acid and lanthanum acetate pentahydrate and sodium hydroxide undergo a thermal reaction in a mixed solvent of N,N-dimethylformamide / ethanol / water. The synthetic method disclosed by the present invention is convenient in operation, high in yield, and good in reproducibility. The lanthanum coordination polymer has excellent catalytic activity on the glycolide ring-opening; the weight-average molecular weight of the prepared polyglycolide is over 90000, and the prepared polyglycolide can be used in the field of medical polymeric materials.

Description

technical field [0001] The invention relates to the field of polyglycolide catalysts, in particular to a lanthanum coordination polymer, a preparation method thereof and an application of catalyzing the ring-opening polymerization of glycolide. Background technique [0002] Polyglycolide, also known as polyglycolic acid and polyglycolic acid, referred to as PGA, is a linear aliphatic polyester with the simplest structure, and it is also the first medical synthetic product approved by the US FDA for use as absorbable surgical sutures. Polymer material (trade name: Dexon ). Due to its good biocompatibility, non-toxicity and adjustable degradation, PGA has great potential in medical absorbable surgical sutures, drug sustained / controlled release carrier materials, simulated human tissue materials, and biodegradable polymer scaffold materials. Broad application prospects (Middleton J.C., Tipton A.J. Biomaterials 2000, 21, 2335-2346). [0003] PGA can be synthesized by direct ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00C08G63/08C08G63/84
Inventor 陈圣春戴安琪崔爱军何明阳陈群
Owner CHANGZHOU UNIV