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Instant collagen lyophilized ball and preparation method thereof

A collagen jelly, instant technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of reduced antioxidant capacity, irritating preservatives, easy skin aging, etc., and achieves long shelf life and strong hydrophilicity. The effect of sex, convenient storage

Inactive Publication Date: 2015-11-25
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, preservatives are often irritating to a certain extent. Long-term use of skin care products containing preservatives may make the skin prone to aging, reduce antioxidant capacity, etc., and may even cause allergies

Method used

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  • Instant collagen lyophilized ball and preparation method thereof
  • Instant collagen lyophilized ball and preparation method thereof
  • Instant collagen lyophilized ball and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prepare a collagen solution with a concentration of 10mg / mL, add a certain amount of phthalic anhydride while stirring to make the final concentration 0.5mg / mL, control the reaction pH to 4, the reaction time is 1h, and the reaction temperature is 20°C. After the reaction, the reaction solution is placed in a dialysis bag for dialysis, and after the dialysis, the acylated collagen solution is freeze-dried to obtain an acylated collagen sponge. Pour 100g of deionized water into the main pot, add 0.1g of acylated collagen freeze-dried product and stir until completely dissolved, then add 0.4g of mannitol, 0.1g of pullulan, and 0.1g of trehalose in sequence, and stir well. After stirring evenly, take a sample, test the pH value, smell and other sensory indicators, and carry out microbial detection. After passing the test, it is filled and freeze-dried to obtain instant collagen freeze-dried balls.

[0025] The specific usage and dosage of collagen freeze-dried balls for be...

Embodiment 2

[0027] Prepare a collagen solution with a concentration of 15mg / mL, add a certain amount of phthalic anhydride while stirring to make the final concentration 1.5mg / mL, control the reaction pH to 5, the reaction time is 2h, and the reaction temperature is 25°C. After the reaction, the reaction solution is placed in a dialysis bag for dialysis, and after the dialysis, the acylated collagen solution is freeze-dried to obtain an acylated collagen sponge. Pour 100g of deionized water into the main pot, add 0.15g of acylated collagen freeze-dried product and stir until completely dissolved, then add 0.6g of mannitol, 0.15g of pullulan, and 0.15g of trehalose in sequence, and stir well. After stirring evenly, take a sample, test the pH value, smell and other sensory indicators, and carry out microbial detection. After passing the test, it is filled and freeze-dried to obtain instant collagen freeze-dried balls.

[0028] Concrete usage and consumption are with embodiment 1.

Embodiment 3

[0030] Prepare a collagen solution with a concentration of 20mg / mL, add a certain amount of phthalic anhydride while stirring to make the final concentration 3mg / mL, control the reaction pH to 7, the reaction time is 2h, and the reaction temperature is 30°C. After the reaction, the reaction solution is placed in a dialysis bag for dialysis, and after the dialysis, the acylated collagen solution is freeze-dried to obtain an acylated collagen sponge. Pour 100g of deionized water into the main pot, add 0.2g of acylated collagen freeze-dried product and stir until completely dissolved, then add 0.8g of mannitol, 0.15g of pullulan, and 0.15g of trehalose in sequence, and stir well. After stirring evenly, take a sample, test the pH value, smell and other sensory indicators, and carry out microbial detection. After passing the test, it is filled and freeze-dried to obtain instant collagen freeze-dried balls.

[0031] Concrete usage and consumption are with embodiment 1.

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Abstract

The invention discloses an instant collagen lyophilized ball which comprises the following components in percentage by mass: 14-20% of collagen, 10-15% of trehalose, 10-15% of pullulan, 30-56% of mannitol and 10-20% of sterile injection water. The invention further discloses a preparation method of the instant collagen lyophilized ball. The instant collagen lyophilized ball has the repairing function; the prepared collagen lyophilized ball has very strong hydrophilicity, can be quickly and uniformly dissolved in the use moment, and can be used for reparation and maintenance of skin suffered from medical plastic surgeries of laser, photon, refrigeration, high frequency, grinding, face-lifting and the like; the instant collagen lyophilized ball can be used for treating skin damages, caused by acne or trauma, of depressed scars, couperose skin symptom, skin atrophy, sun burn, heat injury and the like. The instant collagen lyophilized ball prepared according to the method has very strong hydrophilicity, can be uniformly dissolved instantly when in use, is more convenient and fast to use and long in guarantee period, can be stored at the room temperature, and is very convenient to store.

Description

technical field [0001] The invention relates to an instant collagen freeze-dried ball and a preparation method thereof. Background technique [0002] Collagen is the most important water-insoluble fibrin outside the cell, and it is the skeleton of the extracellular matrix. Collagen forms semi-crystalline fibers in the extracellular matrix, provides tension and elasticity to cells, and plays a role in cell migration and development. Collagen is present in various animals. Collagen is abundant in tendon, cartilage and bone in vertebrates, accounting for almost half of the total protein weight. [0003] Animal-derived collagen has a similar structure to human skin collagen, has good biocompatibility, can quickly penetrate into the deep layer of the skin, and has a good nutritional effect on the skin. In addition, there are amino acids such as hydroxyproline and hydroxylysine with a large number of carboxyl and hydroxyl groups in collagen, and a large amount of natural moistu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/65A61K8/34A61K8/02A61Q19/00A61Q19/02A61Q19/08A61Q17/04
Inventor 任伟业陆金婷程咏梅赵颖
Owner 无锡贝迪生物工程股份有限公司
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