The invention provides a photodiffusion release film. The photodiffusion release film comprises a film layer, wherein the film layer contains the following raw materials in parts by weight: TPX, PC, PFA, PBT, nano barium sulfate, nano-silica, polyetherimide, phenol-formaldehyde resin, polyurethane, polyimide, 2-ethyl methacrylate, organic montmorillonite, ethylene glycol, a silane coupling agent, an antioxidant, a photostabilizer, an antifoamer and a thickener. The photodiffusion release film has an excellent optical diffusion effect and has good peeling strength and tensile strength; secondly, the photodiffusion release film is flat and smooth in surface, has good thermal stability and thermal shrinkage ratio, can resist photoaging and can be reused repeatedly; in addition, the photodiffusion release film provided by the invention is environmentally friendly and non-toxic, the synthesis method is simple, is simple and convenient in operation and moderate in condition and is applicable to industrial production.