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Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof

A technology of epidermal growth factor and compound, applied in skin care preparations, skin diseases, drug combinations, etc., can solve the problems of prolonged effective time of nutrients and active substances, low bioavailability, poor stability, etc., to maintain skin Natural health, less skin irritation, and stable properties

Active Publication Date: 2014-02-19
GUANGZHOU GIALEN COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is sensitive to enzymes, light, PH value, etc., and has the characteristics of poor stability, easy inactivation, and low bioavailability, which greatly limits its practical application. In response to these problems, after years of research, the combination of epidermal growth factor and The combination of nutrients and essences forms a mutual synergy, and white polysaccharides are used as carriers in cosmetics, which greatly prolongs the effective time of nutrients and active substances. The infiltration of various nutrients and active substances into cells is fully Absorption and utilization make cosmetics not only have the effects of skin care, nourishment and protection, but also participate in the metabolism of cells, fundamentally make the skin smooth and elastic, and keep the skin natural and healthy

Method used

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  • Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof
  • Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof
  • Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) 10 parts by mass of Ganoderma lucidum and 10 parts by mass of Mushizi were washed, dried, crushed and passed through a 40-mesh sieve to obtain a coarse powder;

[0032] (2) Extract according to the dynamic countercurrent extraction process of the tank group. The number of tanks is 3 as a batch. Put the above coarse powder into each tank, add 10 times the volume of the coarse powder in water, heat to 75°C, and keep the extraction for 30 minutes. Collect the extract to the storage tank; after multi-stage dynamic circulation countercurrent extraction, combine the extract;

[0033] (3) After centrifugal filtration, the extract is concentrated to a relative density of 1.03-1.05; a concentrated solution is obtained;

[0034] (4) Dissolve 0.5 parts by mass of epidermal growth factor and the concentrated solution obtained in step (3) in the aqueous solution of Baiji polysaccharide, and mix well to obtain EGF complex I loaded with Baiji polysaccharide; the aqueous solution o...

Embodiment 2

[0036] (1) Wash and dry 20 parts by mass of Ganoderma lucidum and 20 parts by mass of Chu Shizi, crush them through a 40-mesh sieve to obtain a coarse powder;

[0037] (2) Extract according to the dynamic countercurrent extraction process of the tank group. The number of tanks is 3 as a batch. Put the above-mentioned coarse powder into each tank, add 12 times the volume of the coarse powder in water, heat to 80°C, and keep the extraction for 35 minutes. Collect the extract to the storage tank; after multi-stage dynamic circulation countercurrent extraction, combine the extract;

[0038](3) After centrifugal filtration, the extract is concentrated to a relative density of 1.03-1.05; a concentrated solution is obtained;

[0039] (4) Dissolve 1 mass part of epidermal growth factor and the concentrated solution obtained in step (3) in the aqueous solution of Baiji polysaccharide, and mix well to obtain the EGF complex II carried by Baiji polysaccharide; the aqueous solution of Bai...

Embodiment 3

[0041] (1) Wash and dry 25 parts by mass of Ganoderma lucidum and 25 parts by mass of Chu Shizi, crush and pass through a 40-mesh sieve to obtain a coarse powder;

[0042] (2) Extract according to the dynamic countercurrent extraction process of the tank group. The number of tanks is 4 as a batch. Put the above-mentioned coarse powder into each tank, add 15 times the volume of the coarse powder in water, heat to 85°C, and keep the heat for extraction for 40 minutes. Collect the extract to the storage tank; after multi-stage dynamic circulation countercurrent extraction, combine the extract;

[0043] (3) After centrifugal filtration, the extract is concentrated to a relative density of 1.03-1.05; a concentrated solution is obtained;

[0044] (4) Dissolve 2 parts by mass of epidermal growth factor and the concentrated solution obtained in step (3) in the aqueous solution of Baiji polysaccharide, and mix evenly to obtain the EGF complex III carried by Baiji polysaccharide; the aq...

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Abstract

The invention discloses an epidermal growth factor-loaded bletilla rhizome polysaccharide compound and a preparation method and application thereof, belonging to the field of traditional Chinese medicine compounds. An epidermal growth factor composite liposome is prepared from the following raw materials by weight: 0.5 to 5 parts of an epidermal growth factor, 10 to 50 parts of lucid ganoderma, 10 to 50 parts of paper mulberry fruit and 5 to 20 parts of bletilla rhizome polysaccharide. The preparation method provided by the invention is simple, and the prepared epidermal growth factor-loaded bletilla rhizome polysaccharide compound has the advantages of safety, no toxicity, small skin irritation, mild properties and stable effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine compounds, and in particular relates to a polysaccharide-loaded epidermal growth factor compound of Radix Bleu and its preparation method and application. Background technique [0002] Epidermal growth factor (EGF) is a substance that regulates cell proliferation and differentiation. It can delay the aging of skin cells, promote the repair and growth of human skin cells, and make the skin smooth and delicate. However, it is sensitive to enzymes, light, PH value, etc., and has the characteristics of poor stability, easy inactivation, and low bioavailability, which greatly limits its practical application. In response to these problems, after years of research, the combination of epidermal growth factor and The combination of nutrients and essences forms a mutual synergy, and white polysaccharides are used as carriers in cosmetics, which greatly prolongs the effective time of nutrients an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/97A61K8/64A61K8/73A61K8/06A61K8/02A61Q19/02A61Q19/00A61Q19/08A61P17/00
Inventor 傅国华候爱霞
Owner GUANGZHOU GIALEN COSMETICS
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