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Veterinary compound dextriferron injection and preparation method thereof

A technology for injections and saccharin, applied in the field of veterinary compound saccharin injection and its preparation, can solve the problems of single function and single blood enrichment effect, achieve good oral absorption, high drug utilization, and enhance immunity Effect

Inactive Publication Date: 2015-11-25
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing iron dextran injection products on the market only have a single blood-enriching effect, and the function is relatively single

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A veterinary compound saccharin injection, which contains the following components per 100ml injection: 5g of iron dextran, 1g of dysentery, 1g of sodium salicylate, 0.1g of thiourea, and the balance is water for injection.

[0019] The preparation method of above-mentioned veterinary compound animal blood element injection, it comprises the following steps:

[0020] 1) Take 10% of the prescribed amount of water for injection, add the prescribed amount of sodium salicylate and thiourea, heat to dissolve at 50°C, then add the prescribed amount of Shigella, and stir to completely dissolve;

[0021] 2) Take the prescribed amount of iron dextran, add 85% of the prescribed amount of water for injection, and stir to dissolve;

[0022] 3) Mix the products of step 1) and step 2), add glacial acetic acid to adjust the pH to 5.0, mix well, add water for injection to make up to 100ml, filter, pot, and sterilize at 105°C for 30 minutes to obtain the finished injection.

Embodiment 2

[0024] A veterinary compound saccharin injection, which contains the following components per 100ml injection: 10g of iron dextran, 2g of dysentery, 5g of sodium salicylate, 0.2g of sodium bisulfite, and the balance is water for injection.

[0025] The preparation method of above-mentioned veterinary compound animal blood element injection, it comprises the following steps:

[0026] 1) Take 10% of the prescribed amount of water for injection, add the prescribed amount of sodium salicylate and sodium bisulfite, heat to dissolve at 60°C, then add the prescribed amount of Shigaojing, stir to dissolve completely;

[0027] 2) Take the prescribed amount of iron dextran, add 85% of the prescribed amount of water for injection, and stir to dissolve;

[0028] 3) Mix the products of step 1) and step 2), add 0.1mol / L hydrochloric acid to adjust the pH to 4.0, mix well, add water for injection to make up to 100ml, filter, pot, and sterilize at 105°C for 20 minutes to obtain the finished p...

Embodiment 3

[0030] A veterinary compound saccharin injection, which contains the following components per 100ml injection: 15g of iron dextran, 5g of dysentery, 805g of Tween, 0.5g of sodium metabisulfite, and the balance is water for injection.

[0031] The preparation method of above-mentioned veterinary compound animal blood element injection, it comprises the following steps:

[0032] 1) Take 10% of the prescribed amount of water for injection, add the prescribed amount of Tween 80 and sodium metabisulfite, heat to dissolve at 70°C, then add the prescribed amount of Shigae, and stir to dissolve completely;

[0033] 2) Take the prescribed amount of iron dextran, add 85% of the prescribed amount of water for injection, and stir to dissolve;

[0034] 3) Mix the products of step 1) and step 2), add 0.1mol / L sodium hydroxide to adjust the pH to 8.0, mix well, add water for injection to make up to 100ml, filter, pot, and sterilize at 105°C for 20min, that is Obtain finished product injecti...

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Abstract

The invention belongs to the technical field of veterinary drugs and in particular relates to veterinary compound dextriferron injection. Every 100ml of injection comprises the following components: 5-20g of dextriferron, 1-10g of mequindox, 1-20g of cosolvent, 0.1-1.0g of antioxidant and the balance of water for injection, wherein the cosolvent is one or more than two of Tween80, sodium salicylate, sodium citrate, sodium tartrate and PEG 6000; the antioxidant is one or more than two of thiourea, sodium metabisulphite, vitamin C, sodium hydrogen sulphite and sodium sulphite; and a pH regulator is hydrochloric acid, glacial acetic acid, ethanol amine or sodium hydroxide. The veterinary compound dextriferron injection has good hematogenesis and dysentery stopping effects and can be used for treating iron-deficiency anemia of newborn piglets, blood is enriched while escherichia coli-induced diarrhea of the piglets can be prevented and treated, and survival rate of the newborn piglets can be obviously improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a compound veterinary blood injection with the functions of producing blood, stopping dysentery and improving immunity of a body and a preparation method thereof. Background technique [0002] Iron-deficiency anemia in piglets can occur throughout the year, and it occurs more frequently in cold seasons. In suckling piglets, the incidence of iron deficiency anemia can reach 30-50%, and the mortality rate can reach 15-20%. If it is found that the treatment is not timely, it is easy to cause exhaustion and death of piglets, which will bring economic losses to the pig farm. Iron is the raw material for the synthesis of hemoglobin and is an essential trace element for the growth and development of suckling piglets. The iron storage in newborn piglets is 30 mg / kg body weight. Normal growth requires 7 mg of iron per day, and up to 1 mg of iron can be obtained ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/721A61P37/04A61P3/02A61P1/00A61P1/12A61P31/04A61K31/498
Inventor 赖登明张遂平郭芳茹苑青艳吴胜耀章四新蒋士传刘冬梅牛咏梅王黎明
Owner 河南亚卫动物药业有限公司
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