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Antithrombotic artificial blood vessel

An artificial blood vessel and antithrombin technology, applied in the field of artificial blood vessels, can solve the problems of reduced cell adhesion, achieve the effect of promoting intima formation and maintaining antithrombotic properties

Inactive Publication Date: 2017-09-08
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, there is a problem that the adhesion of cells decreases due to the binding of extremely hydrophilic heparin to the fiber surface.

Method used

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  • Antithrombotic artificial blood vessel
  • Antithrombotic artificial blood vessel
  • Antithrombotic artificial blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0100] Specific examples of the artificial blood vessel of the present invention will be described in detail below.

[0101] (Example)

[0102] 55Dtex-48f polyethylene terephthalate is used for the warp, and 245Dtex-40f polymer array fiber is used for the weft, and the tubular fabric is made of plain weave. In the polymer array fiber used at this time, the sea component was 20 parts of polystyrene, the island component was 80 parts of polyethylene terephthalate, and the number of islands was 36 / f. The tubular fabric was sufficiently treated with an aqueous sodium hydroxide solution at 80° C., then immersed in toluene, fluffed with a fluffing machine, and further subjected to water jet punching.

[0103] The tubular fabric after the above treatment was treated with 0.5% sodium hydroxide aqueous solution, followed by oxidation treatment with 5% potassium permanganate. Next, the compounds of the general formulas (V) to (VIII) obtained by introducing an amino group into the end ...

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Abstract

An object of the present invention is to provide a prosthetic blood vessel capable of long-term non-occlusion that promotes intimal formation after indwelling and maintains antithrombotic properties until intimal formation. The present invention provides an artificial blood vessel, which is a tubular fabric provided with an ultrafine fiber layer containing ultrafine fibers having a fiber diameter of 10 nm to 3 μm inside a fiber layer containing ultrafine fibers, and has a polymer chain other than heparin. The antithrombin agent is covalently bonded to the ultrafine fiber via the polymer chain, and the thrombin activity inhibition ratio on the fiber surface at 37° C. is 60% or more.

Description

technical field [0001] The present invention relates to an artificial blood vessel used for reconstruction, repair or replacement of damaged blood vessels. Background technique [0002] The number of patients suffering from arteriosclerosis is increasing due to the aging of the population and the increase in metabolic syndrome. Arteriosclerosis is the abnormality of the arterial wall. The high blood sugar state and high lipid state of the blood make the blood vessel wall degenerate, and the blood vessel wall becomes weak or hypertrophic, or calcified and becomes hard and brittle. Such degeneration of blood vessels occurs in any part of blood vessels in the body, and the effect is particularly significant on peripheral blood vessels. [0003] For the treatment of such degenerated blood vessels, in addition to low-invasive intravascular treatments such as balloon dilatation using catheters and stent placement, replacement of damaged blood vessels with autologous blood vessels...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/00A61F2/06
CPCA61L27/507A61L27/18A61L27/54A61L2300/42A61L33/0041A61F2210/0076A61F2250/0067C08L67/02A61F2/86
Inventor 棚桥一裕阪口有佳藤田雅规门胁功治土仓弘至山田谕
Owner TORAY IND INC