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Medicine composition with tiotropium bromide and formoterol, application of medicine composition and preparation

A technology of tiotropium bromide and composition, which is applied in the field of pharmaceutical composition containing tiotropium bromide and formoterol, can solve problems such as being not as convenient as long-acting preparations, achieve improvement of lung function and health status, enhance Diastolic effect, effect of reducing missed or repeated doses

Inactive Publication Date: 2015-12-09
HANGZHOU ZIJIN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main bronchodilators include β2-receptor agonists, anticholinergics, etc. Although the regular use of short-acting bronchodilators is relatively cheap, it is not as convenient as long-acting preparations

Method used

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  • Medicine composition with tiotropium bromide and formoterol, application of medicine composition and preparation
  • Medicine composition with tiotropium bromide and formoterol, application of medicine composition and preparation
  • Medicine composition with tiotropium bromide and formoterol, application of medicine composition and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Comparison of bronchodilation effects of several anticholinergics and β2 receptor agonists

[0026] 1. Animals: 40 guinea pigs, male or female, weighing 300-350 g, were purchased from the Experimental Animal Center of Zhejiang University, license number: SCXK (Zhejiang) 2012-0052, and the animals were bred in the Experimental Animal Center of Zhejiang University.

[0027] 2. Main experimental materials: Medlab biological signal acquisition system, model MedLab-U / 4C501H, Nanjing Meiyi Technology Co., Ltd.; nebulized inhaler, PARITurboBOY, produced by Germany Bairui Company.

[0028] 3. Divide the animals into 5 groups, 8 in each group, respectively model group, tiotropium bromide (Tio)-0.7μg / kg and formoterol (For)-0.35μg / kg group, tiotropium bromide (Tio)-0.7μg / kg and salmeterol (SMTL)-4μg / kg group, ipratropium bromide (IPRA)-9μg / kg and formoterol (For)-0.35μg / kg group, ipratropium bromide (IPRA)-9μg / kg and formoterol (For)-0.35μg / kg group, Tropium bromide (IPRA)-9μg / k...

Embodiment 2

[0037] Effects of tiotropium bromide and formoterol on histamine-induced bronchoconstriction in guinea pigs

[0038] 1. Animals: 96 guinea pigs, male or female, weighing 300-350 g, were purchased from the Experimental Animal Center of Zhejiang University, license number: SCXK (Zhejiang) 2012-0052, and the animals were bred in the Experimental Animal Center of Zhejiang University.

[0039] 2. Main experimental materials: Medlab biological signal acquisition system, model MedLab-U / 4C501H, Nanjing Meiyi Technology Co., Ltd.; nebulized inhaler, PARITurboBOY, produced by Germany Bairui Company.

[0040] 3. Determination of airway resistance and dynamic compliance in guinea pigs: Guinea pigs were anesthetized with 20% urethane. Place the guinea pig in a body plethysmography box, lie on the back and fix it, perform tracheal intubation, and insert the blunt needle of the chest tube into the 4th to 5th intercostal space of the front chest of the guinea pig to measure the intrathoracic pr...

Embodiment 3

[0052] Inhalation aerosol containing tiotropium and formoterol

[0053] Tiotropium Bromide 1.125g

[0054] Formoterol 0.45g

[0055] Ethanol 2000g

[0056] HFA134a8000g

[0057] Aluminum tubes, metering valves 1000 sets

[0058] A total of 100 suction / pieces, 1000 pieces were made.

[0059] Process:

[0060] Disperse formoterol and tiotropium bromide in ethanol in a suitable way, then quantitatively fill aluminum cans and crimp them with a suitable metering valve to form a pressure-resistant airtight container; through pressure filling, the prescription amount of HFA134a propellant Put into an airtight container.

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Abstract

The invention relates to the technical field of medicine preparations, in particular to a medicine composition with tiotropium bromide and formoterol, application of the medicine composition and a preparation. The medicine composition comprises the tiotropium bromide or pharmaceutically acceptable salt of the tiotropium bromide and the formoterol or pharmaceutically acceptable salt of the formoterol. The medicine composition with the tiotropium bromide and the formoterol is applied to preparing medicine for treating respiratory and lung inflammatory diseases. The medicine composition is preferably a tiotropium bromide and formoterol composition with synergistic additive effects. The medicine composition, the application and the preparation have the advantages that as proved by pharmacodynamic experiments, the synergistic additive effects can be realized by the tiotropium bromide and the formoterol which are jointly applied, and accordingly bronchiectasis can be forcefully and quickly realized; the medicine composition and the preparation are used for treating the respiratory and lung inflammatory diseases, and preferably used for treating dyspnea such as bronchial asthma and chronic obstructive pulmonary diseases (COPD) due to bronchial constriction.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing tiotropium bromide and formoterol and its use and preparation. technical background [0002] The respiratory diseases referred to in the present invention mainly include chronic obstructive pulmonary disease (chronic obstructivepulmonarydisease, COPD) and bronchial asthma. [0003] COPD is a preventable and treatable disease characterized by persistent airflow limitation that is mostly progressive and associated with an enhanced chronic inflammatory response of airways and lung tissue to noxious gases or particles such as tobacco smoke . COPD is a common and frequently-occurring disease that seriously endangers human health, seriously affects the quality of life of patients, has a high mortality rate, and brings heavy economic burdens to patients, their families and society. [0004] Global initiative for chronic obstr...

Claims

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Application Information

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IPC IPC(8): A61K31/46A61K9/72A61P11/00A61P29/00A61P11/06A61K31/137
Inventor 谢诒诚李曙民
Owner HANGZHOU ZIJIN PHARMA TECH
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