Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of resveratrol oligomer in drug preparation

A technology of resveratrol and oligomers, which is applied in the application field of resveratrol oligomers in the preparation of medicines, can solve the problems that there are no resveratrol oligomers, etc., and achieve the reduction of expression and wide The effect of applying the foreground

Inactive Publication Date: 2015-12-16
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST +1
View PDF4 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented inventions have shown how certain compounds from plants called resveratolol are able to decrease their production of fats (fat) by reducing enzyme activities involved with lipid biosynthesis processes. These chemicals could potentially find use for treating diseases such as cancer, diabetes, arthritis, etc., which may result from excessive accumulation of lipids inside cells due to insufficient nutrients supplied through food sources like fish oil.

Problems solved by technology

Technologies aimed at developing drugs targeting specific proteins involved with lipirconium saturated carbonate hydride transferring from gamma linolenylic acid to palmitolecitha lauronitrile monophosphorylation reductases (FTs), specifically type I FAS (farnascending aliphatic amino acid shunt regulated pathway system). These research results indicate how these factors affect cellular growth and differentiation processes during embryonic development. However, current methods used to study this effect require large amounts of material due to low efficiency rates associated with purification steps required before testing new drug candidates.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of resveratrol oligomer in drug preparation
  • Application of resveratrol oligomer in drug preparation
  • Application of resveratrol oligomer in drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of embodiment 1 present invention vitisinA, ε-viniferin, vitisinB

[0041] The instruments and reagents used in this embodiment are as follows:

[0042] TBE-300C high-speed countercurrent chromatograph (Shanghai Tongtian Biotechnology Co., Ltd.); also equipped with TBP5002 constant flow pump (Shanghai Tongtian Biotechnology Co., Ltd.), DC-0506 low temperature constant temperature bath (Shanghai Sunny Hengping Scientific Instrument Co., Ltd.) , UV-2000D detector (Shanghai Tongtian Biotechnology Co., Ltd.) and EasyChrom-1000 chromatography data workstation (Shanghai Tongtian Biotechnology Co., Ltd.). Agilent1260 high performance liquid chromatography (Agilent Corporation), equipped with G1311C four-stage pump, G1329B autosampler, G1316A column thermostat and G1315D diode array detector.

[0043] In this embodiment, the HPLC method is used to detect the purity of each fraction (peak area normalization method). The chromatographic conditions are: Eclipse XD...

Embodiment 2

[0047] The drug effect test of embodiment 2 compounds of the present invention

[0048] Material:

[0049] Breast cancer cell line MDA-MB-231, vitisinA, ε-viniferin, vitisinB were prepared by the method in Example 1.

[0050] Acetyl-CoA, malonyl-CoA, and reduced nicotinamide adenine dinucleotide phosphate (Triphosphopyridinenucleotide, NADPH) were purchased from Sigma, USA;

[0051] CellCountingKit was purchased from Japan Dojin Chemical;

[0052] Dulbecco'smodified Eagle'smedium (DMEM) and penicillin, streptomycin were purchased from U.S. Invitrogen Company;

[0053] FAS and β-actin monoclonal antibodies were purchased from Cell Signaling Technology (CST) in the United States;

[0054] Horseradish peroxidase-labeled goat anti-mouse secondary antibody was purchased from Zhongshan Jinqiao Biotechnology Company;

[0055] ECL luminescent liquid, polyvinylidene fluoride (PVDF) membrane, and fetal bovine serum (Fetaibovineserum) were purchased from Zhejiang Tianhang Biotechnolo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the application of a resveratrol oligomer or pharmaceutically acceptable salt thereof in the preparation of a fatty acid synthetase protein expression index lowering type medicine or a fatty acid synthetase restrainer type medicine. The invention further discloses a pharmaceutical composition which is prepared by taking the resveratrol oligomer or the pharmaceutically acceptable salt thereof as an active ingredient and adding pharmaceutically acceptable auxiliary materials. The resveratrol oligomer provided by the invention can effectively lower the fatty acid synthetase protein expression index and also can refrain the activity of fatty acid synthetase, can serve as a medicine for resisting tumour or preventing and curing obesity, and has a broad application prospect.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com