A kind of phospholipid surfactant multi-structure liposome and preparation method thereof

A surfactant and structured lipid technology, applied in the field of phospholipid surfactant multi-structure liposome and its preparation, can solve the problems of high irritation and high emulsifier content, and achieve enhanced moisture retention, simple operation, and good moisture retention and the effect of permeability

Active Publication Date: 2018-10-12
上海欧润化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the above-mentioned technical problems in the prior art, the invention provides a kind of phospholipid surfactant multi-structure liposome and preparation method thereof, described this phospholipid surfactant multi-structure liposome and preparation method thereof have solved The technical problem of high content of emulsifier in the multi-structure liposome in the prior art and great irritation

Method used

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  • A kind of phospholipid surfactant multi-structure liposome and preparation method thereof
  • A kind of phospholipid surfactant multi-structure liposome and preparation method thereof
  • A kind of phospholipid surfactant multi-structure liposome and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] A phospholipid surfactant multi-structure liposome, calculated by weight percentage, its raw material composition and content are as follows:

[0050]

[0051] Described phospholipid is lecithin, the industrial grade product of the cosmetics that Shanghai Heshan Industrial Co., Ltd. provides;

[0052] Described co-emulsifier is cetyl polyethylene glycol, the industrial grade product of the cosmetics that Shanghai Evonik Degussa Specialty Chemicals Co., Ltd. provides;

[0053] Described liquid oil is caprylic acid / capric triglyceride, the industrial grade product that the cosmetics that BASF (China) Co., Ltd. provides;

[0054] Described additive is Potassium Chloride, the industrial grade product that the cosmetics that Shanghai Titan Technology Co., Ltd. provides;

[0055] The preservative is imidazolidinyl urea.

[0056] The preparation method of this phospholipid surfactant multiple structure liposome:

[0057] (1) Mix 1.0 g of lecithin with 0.05 g of cetyl pol...

Embodiment 2

[0067] A phospholipid surfactant multi-structure liposome, calculated by weight percentage, its raw material composition and content are as follows:

[0068]

[0069] Described phospholipid is lecithin, the industrial grade product of the cosmetics that Shanghai Heshan Industrial Co., Ltd. provides;

[0070] The co-emulsifier is arachidyl alcohol, behenyl alcohol and arachidyl alcohol glucoside, an industrial-grade product for cosmetics provided by Sebec Co., Ltd. of France;

[0071] Described liquid oil is caprylic acid / capric triglyceride, the industrial grade product that the cosmetics that BASF (China) Co., Ltd. provides;

[0072] Described additive is Potassium Chloride, the industrial grade product that the cosmetics that Shanghai Titan Technology Co., Ltd. provides;

[0073] The preservative is imidazolidinyl urea.

[0074] The preparation method of this phospholipid surfactant multiple structure liposome:

[0075] (1) Mix 5.0g of lecithin with 0.25g of arachidyl ...

Embodiment 3

[0081] A phospholipid surfactant multi-structure liposome, calculated by weight percentage, its raw material composition and content are as follows:

[0082]

[0083] Described phospholipid is lecithin, the industrial grade product of the cosmetics that Shanghai Heshan Industrial Co., Ltd. provides;

[0084] Described co-emulsifier is cetearyl alcohol and cetearyl glucoside, the industrial-grade product that the cosmetics that France Sepic company provides;

[0085] Described liquid oil is caprylic acid / capric triglyceride, the industrial grade product that the cosmetics that BASF (China) Co., Ltd. provides;

[0086] Described additive is Potassium Chloride, the industrial grade product that the cosmetics that Shanghai Titan Technology Co., Ltd. provides;

[0087] The preservative is imidazolidinyl urea.

[0088] The preparation method of this phospholipid surfactant multi-structure liposome:

[0089] (1) Mix 10.0g of lecithin with 0.5g of cetearyl alcohol and cetearyl g...

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Abstract

The invention discloses a phospholipid surfactant multi-structure liposome. The phospholipid surfactant multi-structure liposome comprises, by weight, 0.1-20% of phospholipid, 0.01-10% of co-emulsifiers, 0.1-10% of liquid grease, 0.05-5% of additives and the balance deionized water. The invention further provides a preparation method of the phospholipid surfactant multi-structure liposome. The preparation method includes mixing the phospholipid with the co-emulsifiers, the liquid grease and the organic additives, and heating the mixture to obtain an oil-phase component; mixing the inorganic additives with the deionized water, heating the mixture to obtain an aqueous-phase component, and adding the oil-phase component into the aqueous-phase component for homogenization; stirring and cooling at a high speed until the temperature is lowered to the room temperature, adding preservatives, and continuing to stir to obtain the phospholipid surfactant multi-structure liposome. The phospholipid surfactant multi-structure liposome has the advantages that a multi-structure can be formed by phospholipid surfactant, namely lecithin, applied in the preparation method through self-assembly, simplicity in operation is achieved, high skin moisture retention and penetrability are realized, and cosmetics made from the phospholipid surfactant multi-structure liposome are more safe and reliable.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to a phospholipid surfactant multi-structure liposome and a preparation method thereof. Background technique [0002] The multiple structure system is a composite system in which the oil-in-water (O / W) type and the water-in-oil (W / O) type coexist. The defect of greasy feeling has both the advantages of both. In the development process of new cosmetics, multiple structure system can be said to be one of the most promising ideal systems, but due to its special structure, the general preparation method of multiple structure is a two-step method, and the operation is complicated. [0003] At present, there have been many studies on multi-structure liposomes, but the multi-structure liposomes of phospholipid surfactants have not been disclosed yet. Contents of the invention [0004] For the above-mentioned technical problems in the prior art, the invention provides a kind of phosphol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/14A61K8/86A61K8/60A61K8/55A61Q19/00
CPCA61K8/14A61K8/553A61K2800/10A61Q19/00
Inventor 张婉萍贾兵杨雪芳朱海洋
Owner 上海欧润化妆品有限公司
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