Preparation method and application of decoction-free traditional Chinese fruit medicine preparation

A technology of Chinese medicinal materials and decoction-free preparation, which is applied in the field of preparation of decoction-free preparations of fruit-based Chinese medicinal materials. It can solve the problems of changes in heat-sensitive active ingredients, destruction of active ingredients of medicinal materials, and complex chemical components, and achieves protection from heat instability and easy oxidation. ingredients, increased solvent penetration, good separation effect

Inactive Publication Date: 2016-01-13
HENAN XINGZHI PATENT SERVICE CO LTD
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  • Description
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AI Technical Summary

Problems solved by technology

[0004] The preparation of traditional Chinese medicine preparations generally adopts methods such as decoction, reflux, and percolation for extraction, but these extraction methods tend to cause changes in heat-sensitive active ingredients when the temperature rises during the extraction process, and the extraction yield is low. Long time and cumbersome process
Due to the complex chemical composition of fruit Chinese medicinal materials, traditional extraction methods will destroy the active ingredients in the medicinal materials

Method used

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  • Preparation method and application of decoction-free traditional Chinese fruit medicine preparation

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preparation example Construction

[0028] A preparation method of fruit-like Chinese medicinal material free decoction, comprising the following steps:

[0029] 1) Pick up the fruit-like Chinese medicinal materials, remove impurities, and dry;

[0030] 2) Grinding the dried Chinese medicinal materials into fine powder of Chinese medicinal materials with a particle size of 100-150 μm with an ultrafine pulverizer;

[0031] 3) Put the fine powder of Chinese medicinal materials obtained in step 2) into supercritical CO 2 Extraction is carried out in the extraction device, and then enters the separation tank for separation to obtain extracts and medicinal residues;

[0032] 4) Add 10 to 20 times the volume of water to the dregs obtained in step 3), soak for 60 to 120 minutes at 40 to 50°C, then add 0.3% to 0.8% of the dregs weight of cellulase and 0.1 %~0.5% pectinase for enzymolysis, ultrasonic assisted treatment, to obtain the extract;

[0033] 5) Combine the extract obtained in step 3) and the extract obtained...

Embodiment 1

[0044] Taking Cornus officinalis as an example, the preparation method of its decoction-free preparation comprises the following steps:

[0045] 1) Pick up the dogwood, remove impurities, and dry;

[0046] 2) Grinding the dried Cornus officinalis with an ultrafine pulverizer into fine powder of Cornus officinalis with a particle size of 100-150 μm;

[0047] 3) Put the dogwood fine powder obtained in step 2) into supercritical CO 2 Extraction is carried out in the extraction device, the extraction temperature is 40°C, the pressure is 30MPa, CO 2 The flow rate is 12L / min, the extraction time is 2h, and then it enters the separation tank for separation to obtain the extract and dregs;

[0048] 4) Add 10 times the volume of water to the medicinal dregs obtained in step 3), soak for 60 minutes at 40°C, then add 0.3% of the weight of medicinal dregs to obtain an enzyme activity of 1×10 4 U / g cellulase and 0.1% enzyme activity is 1×10 4 U / g of pectinase, enzymatic hydrolysis for ...

Embodiment 2

[0052] Taking Ligustrum lucidum as an example, the preparation method of its decoction-free preparation comprises the following steps:

[0053] 1) Pick up the privet fruit, remove impurities, and dry;

[0054] 2) Grinding the dried Ligustrum lucidum into a fine powder of Ligustrum lucidum with a particle size of 100-150 μm with an ultrafine pulverizer;

[0055] 3) Put the Ligustrum lucidum fine powder obtained in step 2) into supercritical CO 2 Extraction is carried out in the extraction device, the extraction temperature is 43°C, the pressure is 31MPa, CO 2 The flow rate is 13L / min, the extraction time is 2.5h, and then it enters the separation tank for separation to obtain the extract and dregs;

[0056] 4) Add 13 times the volume of water to the dregs obtained in step 3), soak at 43°C for 70 minutes, then add 0.5% of the dregs by weight, and the enzyme activity is 1×10 4 U / g cellulase and 0.2% enzyme activity is 1×10 4 U / g of pectinase, enzymatic hydrolysis for 120 minu...

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Abstract

The invention belongs to the technical field of preparation of traditional Chinese medicines and particularly relates to a preparation method and application of a decoction-free traditional Chinese fruit medicine preparation. The preparation method includes: subjecting traditional Chinese fruit medicines to ultrafine pulverization prior to supercritical CO2 extraction, subjecting residues left after extraction to enzymolysis, performing ultrasonic-assisted treatment and microfiltration, concentrating, drying, nano pulverizing, sterilizing and packaging to obtain the decoction-free traditional Chinese fruit medicine preparation. The preparation can be used for preparation of traditional Chinese medicine compound preparations containing the traditional Chinese fruit medicines or extracts of the traditional Chinese fruit medicines. The problems of low extraction efficiency, incompleteness in extraction of active ingredients and low utilization rate of raw materials in extraction of traditional Chinese medicines according to a conventional method are solved. The whole technical process is simple in control and environment friendly; due to synergistic interaction of steps, the preparation method is higher in extraction efficiency, active ingredients are effectively protected, and availability of the traditional Chinese fruit medicines is better improved.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and in particular relates to a preparation method and an application of a decoction-free preparation of fruit-like Chinese medicinal materials. Background technique [0002] Traditional Chinese medicine is a unique medicine of traditional Chinese medicine, with a long history and rich resources. The ingredients of traditional Chinese medicine are complex and diverse. If the appropriate extraction, concentration, preparation process and scientific and strict process operation parameters are not selected during the preparation of traditional Chinese medicine preparations, the active ingredients will be incompletely extracted or even destroyed, thereby affecting the efficacy of the medicine. The traditional dosage forms of traditional Chinese medicine include pills, powders, ointments, liquors, etc., but most of the traditional dosage forms have shortcomings such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/264A61K36/40A61K36/638A61K36/9064A61K36/79A61K36/57A61K36/8994A61K36/815A61P1/10A61P17/00
Inventor 马新攀
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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