A kind of pipemidic acid pharmaceutical composition

A technology of pipemidic acid and composition, applied in the field of pipemidic acid pharmaceutical composition and preparation thereof, can solve the problems of patient suffering and difficult to cure, and achieve the effects of improving compliance, rapid dissolution and rapid drug effect

Active Publication Date: 2019-02-01
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of these diseases is mainly oral, intramuscular injection or intravenous infusion of antibiotics and anti-allergic drugs, but sometimes the curative effect is not good enough to develop into chronic diseases, which are not easy to cure and cause pain to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] Pipemidic acid 250g

[0024] Mannitol 200g

[0025] Poloxamer 30g

[0026] Sodium Carboxymethyl Cellulose 2g

[0027] Sodium carboxymethyl starch 15g

[0028] Magnesium Stearate 3g

[0029] A total of 1000 pieces were made

[0030] Preparation:

[0031] 1) Pass pipemidic acid through a 100-mesh sieve, and set aside; mannitol, poloxamer, sodium carboxymethyl starch, and magnesium stearate are respectively passed through a 60-mesh sieve, set aside;

[0032] 2) Mix the sieved pipemidic acid, mannitol and poloxamer evenly;

[0033] 3) Add the prescribed amount of sodium carboxymethylcellulose into purified water and stir evenly to make an aqueous solution of sodium carboxymethylcellulose with a concentration of 0.5% for later use;

[0034] 4) Add the prepared sodium carboxymethylcellulose aqueous solution to the mixture in step 2), and continue to stir to make a suitable soft material;

[0035] 5) Make the soft material in step 4) into wet g...

Embodiment 2

[0037] prescription

[0038] Pipemidic acid 250g

[0039] Lactose 105.6g

[0040] Microcrystalline Cellulose 123.4g

[0041] Hydroxypropyl Methyl Cellulose 2.5g

[0042] Sodium carboxymethyl starch 15g

[0043] Magnesium Stearate 3.5g

[0044] A total of 1000 pieces were made

[0045] Preparation:

[0046] 1) Pass pipemidic acid through a 100-mesh sieve, and set aside; lactose, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate respectively pass through a 60-mesh sieve, set aside;

[0047] 2) Mix the sieved pipemidic acid, lactose and microcrystalline cellulose evenly;

[0048] 3) Add the prescribed amount of hydroxypropyl methylcellulose into purified water and stir evenly to make an aqueous solution of sodium carboxymethylcellulose with a concentration of 0.5% for later use;

[0049] 4) Add the prepared hydroxypropyl methylcellulose aqueous solution to the mixture in step 2), and continue to stir to make a suitable soft material;

[00...

Embodiment 3

[0052] prescription

[0053] Pipemidic acid 250g

[0054] Microcrystalline Cellulose 445.3g

[0055] Starch 358.5g

[0056] Poloxamer 86.1g

[0057] povidone k30 25.6g

[0058] Sodium carboxymethyl starch 75g

[0059] Magnesium Stearate 9.5g

[0060] A total of 1000 pieces were made

[0061] Preparation:

[0062] 1) Pass pipemidic acid through a 100-mesh sieve, and set aside; microcrystalline cellulose, starch, poloxamer, sodium carboxymethyl starch, and magnesium stearate respectively pass through a 60-mesh sieve, set aside;

[0063] 2) Mix the sieved pipemidic acid, starch, microcrystalline cellulose and poloxamer evenly;

[0064] 3) Add the prescribed amount of povidone K30 into 75% ethanol and stir evenly to make a 2% povidone K30 solution for later use;

[0065] 4) Add the prepared povidone K30 solution to the mixture in step 2), and continue stirring to make a suitable soft material;

[0066] 5) Make the soft material in step 4) into wet granules with 18-mesh...

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PUM

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Abstract

The invention provides a pipemidic acid pharmaceutical composition which is characterized by being prepared from, by weight, 20-70% of pipemidic acid and 30-80% of pharmaceutic adjuvants. According to the pharmaceutical properties of pipemidic acid, the formula is scientific, the dissolving and absorbing speed of the medicine is increased, the composition is safe and non-toxic, medicine compliance of a patient is good, and the effect is remarkable.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pipemidic acid pharmaceutical composition and a preparation method thereof. Background technique [0002] Pipemidic acid, English name: Pipemidic Acid, Chinese alias piperic acid, English alias Doliol, PiperamicAcid, Pipram, this product is light yellow or light yellow crystalline powder; odorless, bitter taste. This product is slightly soluble in methanol or dimethylformamide, very slightly soluble in water or chloroform, insoluble in ethanol, ether or benzene; easily soluble in sodium hydroxide test solution or glacial acetic acid. The melting point of this product is 251-256°C, and it decomposes at the same time when it melts. It is clinically used as an enema liquid for treating diarrhea. [0003] Dysentery, enteritis, ulcerative colitis, etc. are diseases with diarrhea as the main symptom. The treatment of these diseases is mainly based on oral, intramuscular i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K9/20A61K47/26A61K47/10A61P1/12
Inventor 曾培安郑和校吴健民张静
Owner KAMP PHARMA
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