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Paeonol gastric floating tablet and preparation method thereof

A technology of gastric floating tablets and paeonol, which is applied in the field of traditional Chinese medicine gastric floating tablets and its preparation, can solve the problems of short biological half-life, poor water solubility of paeonol, and drug residence in the stomach

Inactive Publication Date: 2016-02-03
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, paeonol has poor water solubility, is easy to oxidize, and has a short biological half-life. It is difficult for common preparations on the market to allow the drug to stay in the stomach for a long time, so as to achieve local high-efficiency and long-term treatment of gastric diseases.

Method used

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  • Paeonol gastric floating tablet and preparation method thereof
  • Paeonol gastric floating tablet and preparation method thereof
  • Paeonol gastric floating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048]

[0049] The prescription content of each tablet of the gastric floating tablet is as shown in the above table, and 1000 tablets are prepared. The specific process is as follows:

[0050] Step 1, pass the prescribed amount of paeonol through a 60-mesh sieve, and set aside; pass the prescribed amount of slow-release matrix material, porogen, and diluent through a 80-mesh sieve, set aside;

[0051] Step 2, mix paeonol with the prescribed amount of glidant, then add diluent, porogen, and slow-release framework material in sequence, pass through an 80-mesh sieve after mixing, and set aside;

[0052] In the third step, the mixed powder obtained in the second step is directly compressed into tablets to make plain tablets.

Embodiment 2

[0054]

[0055] The prescription content of each tablet of the gastric floating tablet is as shown in the above table, and 1000 tablets are prepared, and the specific process is the same as that in Example 1.

Embodiment 3

[0058] The prescription content of each tablet of the gastric floating tablet is as shown in the above table, and 1000 tablets are prepared. The specific process is as follows:

[0059] Step 1, pass the prescribed amount of paeonol through a 60-mesh sieve, and set aside; pass the prescribed amount of slow-release matrix material, porogen, and diluent through a 80-mesh sieve, set aside;

[0060] Step 2, mix paeonol with the prescribed amount of flow aid, then add diluent, porogen, and slow-release framework material in sequence, pass through a 60-mesh sieve after mixing, and set aside;

[0061] In the third step, the mixed powder obtained in the second step is directly compressed into tablets to make plain tablets.

[0062] In step 4, the plain tablet obtained in step 3 is film-coated, and the coating material used is For western medicine, the coating conditions are: water is the solvent, the concentration of the coating solution is 12%, the weight gain of the coating ...

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Abstract

The invention relates to the field of medicinal preparations, in particular to a paeonol gastric floating tablet. The tablet is prepared from the components such as 20 to 50 percent of paeonol, 15 to 30 percent of sustained-release matrix material, 10 to 25 percent of pore-foaming agent, 0.5 to 2 percent of flow aid and 10 to 30 percent of diluent; powder is directly subjected to tabletting to prepare the gastric floating tablet. The paeonol gastric floating tablet is short in floating starting time, long in floating duration, good in stability and capable of achieving a sustained-release effect of sustained release.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a traditional Chinese medicine gastric floating tablet and a preparation method thereof. Background technique [0002] Paeonol, also known as paeonol, is a biologically active substance isolated from traditional Chinese medicine Xu Changqing and Moutan cortex. Paeonol is a drug with a wide range of pharmacological activities, high efficiency and low toxicity, mainly antibacterial and anti-inflammatory, improving hemorheology, lowering lipids, inhibiting lipid peroxidation, anti-tumor, anti-inflammatory and analgesic, and anti-atherosclerosis , enhance immunity, promote microcirculation, anti-arrhythmia and other effects. Studies have shown that paeonol has a good protective effect on gastrointestinal inflammatory diseases such as stress gastric ulcer, and basically has no toxic side effects. According to literature reports, paeonol has a protective effect on gastric u...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/36A61K31/12A61K47/38A61K47/14A61K47/36A61P1/04A61J3/00
Inventor 张彤王冰张溪桐张悦徐本亮赵源
Owner SHANGHAI UNIV OF T C M
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