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Preventive or therapeutic agent for mastitis in ruminants

A technology for mastitis and therapeutic agent, applied in the field of prophylactic or therapeutic agent for mastitis, feed or pharmaceutical composition, and feed additive, can solve problems such as the prevention or treatment of mastitis in cattle that are not recorded with Bacillus subtilis, and achieve high Prophylactic and therapeutic effects, and effects of suppressing the onset of mastitis

Active Publication Date: 2019-11-12
朝日生物循环科技株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in Patent Documents 3, 4 and 5, it is not described that Bacillus subtilis is useful for preventing or treating bovine mastitis.

Method used

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  • Preventive or therapeutic agent for mastitis in ruminants
  • Preventive or therapeutic agent for mastitis in ruminants
  • Preventive or therapeutic agent for mastitis in ruminants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145]

[0146] CALSPORIN (registered trademark; Calpis (strain), Japan) (active ingredient: Bacillus strain C-3102 (FERM BP-1096) 1×10 10 per g) at 6×10 per day 9 One or more doses of raw bacteria were mixed with the feed, and fed from 1 month before delivery to 3 months after delivery. In terms of feed, dairy farmer family MAX (North Japan Cooperative Feed, Japan), ASTRO LINER (vitamin agent: Snow Brand, Japan), flaked corn, roughage (timothy grass, oats, large-grain corn silage, alfalfa hay), feed for dry period (TransPro: Snow Brand, Japan) and roughage (timothy grass, oats) were used during the dry period. On the other hand, for the control plots (cattle numbers 94 and 902) with a history of mastitis shown in the same Table 1, no CALSPORIN was added to the feed.

[0147] Cows known to have a history of mastitis in a previous lactation are at high risk for developing mastitis in this lactation. The previous lactation period refers to the period from the last delivery...

Embodiment 2

[0158]

[0159] Currently, many probiotics for cattle are known, but probiotics that specifically show mastitis preventive or therapeutic effects are unknown. This time, the bifidobacterium proliferation activity, protease activity, and amylase activity of each strain among actually sold probiotics were compared with Bacillus subtilis strain C-3102, which is the target strain of the present invention.

[0160] (1) About strains

[0161] Regarding the adjusted Bacillus strains, including the difference in the shape of the colonies, eight strains of Bacillus subtilis (B. subtilis) and one strain of Bacillus licheniformis (B. licheniformis) shown in Table 3 described later , Bacillus (Bacillus sp.) 2 strains were prepared.

[0162] (2) Preparation of the spore suspension of each thalline

[0163] Each strain was spread on TS agar medium and cultured overnight at 37°C. All the colonies formed on the medium were scraped up with a spoon-shaped bamboo board, and suspended in ste...

Embodiment 3

[0177]

[0178] For lactating dairy cows with a history of mastitis, when mastitis occurs during lactation, CALSPORIN (registered trademark; Calpis (strain)) (active ingredient: Bacillus subtilis strain C-3102 (FERM BP-1096 )1×10 10 per g), 6×10 per day 9 One or more doses of live bacteria are administered for a certain period of time (several days to 1 week) after the onset of disease. In terms of feed, during the lactation period, the dairy farming family MAX (North Japan Cooperative Feed, Japan), ASTRO LINER (vitamin agent: snow seal), flaked corn, roughage (timothy grass, oats, large-grain corn silage, alfalfa hay), During the dry period, feed for dry period (TransPro: Snow Brand, Japan) and roughage (timothy grass, oats) were given.

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Abstract

The present invention relates to a substance or method for preventing or treating mastitis in ruminants, especially dairy cows, in particular, it provides a preventive or therapeutic agent, feed additive, feed or A pharmaceutical composition comprising, as an active ingredient, a bacterium of the genus Bacillus capable of increasing or maintaining CD11c in cattle + CD172a + Blood dendritic cell gate 2.

Description

technical field [0001] The present invention relates to a preventive or therapeutic agent, feed additive, feed or pharmaceutical composition for preventing or treating mastitis in ruminants such as cattle, characterized by containing bacteria of the genus Bacillus having specific properties as an active ingredient. Background technique [0002] Mastitis is an inflammation of breast tissue, and most of its etiology is caused by bacterial infections such as Staphylococcus aureus, Escherichia coli, Streptococcus, and Pseudomonas aeruginosa. In particular, mastitis in cattle is a significant problem for dairy farmers, as described below. [0003] Mastitis is roughly divided into clinical mastitis and recessive mastitis (also known as non-clinical mastitis). In clinical mastitis, visible abnormalities such as redness, swelling, heat, pain, or blood clots in the breast milk can be observed. cause inflammation. Latent mastitis is much higher in terms of occurrence rate, and it i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/742A23K10/18A23K20/195A23K50/10A61P15/14
CPCA23K10/18A23K50/10A61K35/742A61P1/00A61P15/14A61P29/00
Inventor 芦田延久今林宽和麻生久
Owner 朝日生物循环科技株式会社
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