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Water-soluble phloretin solid dispersion and preparation method thereof

A technology of solid dispersion and phloretin, which is applied in the fields of medicine and chemical industry, can solve the problems of low bioavailability and poor water solubility of phloretin, and achieve the effect of simple processing technology, good water solubility and excellent quality

Inactive Publication Date: 2016-03-02
WUYI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to overcome the problems of poor water solubility and low bioavailability of phloretin, and provides a solid dispersion of phloretin with good water solubility and improved performance and a preparation method thereof. The preparation method is simple and efficient, and the operation is simple and convenient

Method used

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  • Water-soluble phloretin solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 10 parts of phloretin and 90 parts of PVP-K30 in a beaker, add an appropriate amount of absolute ethanol to dissolve it completely, stir at room temperature for 3 hours, remove the ethanol by rotary evaporation at 50°C under reduced pressure, dry in vacuum for 10 hours, and crush through an 80-mesh sieve , to obtain water-soluble phloretin solid dispersion.

Embodiment 2

[0025] Take 50 parts of phloretin, 50 parts of PVP-K30, and 2.5 parts of Tween 80 in a beaker, add an appropriate amount of chloroform to dissolve it completely, stir at room temperature for 2 hours, remove the chloroform by rotary evaporation at 40°C, spray dry, and pulverize 80 mesh sieves to obtain a water-soluble phloretin solid dispersion.

Embodiment 3

[0027] Take 10 parts of phloretin and 90 parts of citric acid in a beaker, add an appropriate amount of absolute ethanol to dissolve it completely, stir at room temperature for 6 hours, remove the ethanol by rotary evaporation at 45°C under reduced pressure, freeze-dry, and crush through an 80-mesh sieve to obtain Water-soluble phloretin solid dispersion.

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PUM

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Abstract

The invention relates to a water-soluble phloretin solid dispersion and a preparation method thereof, and belongs to the technical fields of chemical industry and medicine, in particular to a water-soluble phloretin solid dispersion, which has good water solubility and improved anti-inflammation effect, as well as a preparation method thereof. According to a prescription, the water-soluble phloretin solid dispersion with solubility greatly improved is prepared by dissolving phloretin and a carrier in an organic solvent in the ratio of (10-50) parts to (50-90) parts of the phloretin to a high polymer material. In addition, the invention also inspects the anti-inflammation effect of the water-soluble phloretin solid dispersion. The water-soluble phloretin solid dispersion can develop the anti-inflammation effect of the phloretin more effectively; and the water-soluble phloretin solid dispersion disclosed by the invention is wide in raw material source, good in water solubility, high in stability, good in dispersibility, simple in processing technology and excellent in quality. The solid dispersion is applicable to various fields such as foods, health care products, medicines, cosmetics and the like.

Description

technical field [0001] The invention relates to a dispersion and a preparation method thereof, in particular to a water-soluble phloretin solid dispersion and a preparation method thereof. The dispersion is instant in water, has good stability, and has improved anti-inflammatory effects, and belongs to the technical fields of chemical engineering and medicine . Background technique [0002] Phloretin is a natural skin whitening agent newly researched and developed abroad. It is mainly distributed in the peels and root barks of juicy fruits such as apples and pears. Phloretin can activate cellular protein kinase and has curative effect on disordered cell proliferation. It is an antimutagenic factor in food and can be used for the treatment of skin cancer and other tumors. In addition, phloretin can inhibit the activity of melanocytes and has a lightening effect on various skin spots. It can be used in facial masks, skin care creams, lotions and essences. In addition, phlore...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/12A23L33/10A61P17/00A61P29/00A61P35/00A61K8/35A61K8/02A61Q19/02
Inventor 张焜何燕韩雷郑希马诗经程书朋武文敬江森张玉柏利霞徐玉婷杜志云
Owner WUYI UNIV
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