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A traditional Chinese medicine composition, preparation and preparation method thereof with functions of clearing heat and dispelling stagnation

A heat-clearing, stagnation-clearing and compound-prescribing technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, antipyretics, etc., can solve the problems of single ingredients and weak drug effects, and achieve quick results, high cure rate, and improved taste Effect

Active Publication Date: 2017-11-14
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main ingredient of the Qingre Sanjie Capsule is Senecio. Due to the single ingredient and weak drug effect, patients need to take it for a long time or combine it with other drugs to achieve the therapeutic effect.
[0004] In addition, studies have shown that Senecio generally contains unsaturated pyrrolizidine alkaloids, which have certain liver toxicity to humans and animals.
Although no adverse symptoms have been found clinically when taking drugs containing Senecio, its potential risks deserve attention

Method used

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  • A traditional Chinese medicine composition, preparation and preparation method thereof with functions of clearing heat and dispelling stagnation
  • A traditional Chinese medicine composition, preparation and preparation method thereof with functions of clearing heat and dispelling stagnation
  • A traditional Chinese medicine composition, preparation and preparation method thereof with functions of clearing heat and dispelling stagnation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]A compound Qingre Sanjie capsule, which is prepared from the following raw materials in parts by weight: 3000 parts of Senecio, 450 parts of licorice, 60 parts of mint, 160 parts of dextrin, 30 parts of talcum powder, 20 parts of magnesium stearate, and 20 parts of ethanol share.

[0040] The method for preparing above-mentioned capsule, comprises the steps:

[0041] 1) First weigh 3000 parts of Senecio, 450 parts of licorice, and 60 parts of mint. After crushing, pass through a 10-mesh sieve to obtain a coarse powder. o After 3 hours of C reflux extraction, filter to obtain filtrate and filter residue, wherein the volume-to-weight ratio of ethanol to coarse powder is 8mL / g, and ethanol also contains hydrochloric acid that the concentration of 5% is 15% by volume fraction;

[0042] 2) Add ethyl acetate equivalent to 6 times its volume to the above filtrate, extract to obtain the organic phase, repeat the extraction once, combine the organic phase and concentrate it unde...

Embodiment 2

[0049] A traditional Chinese medicine composition with functions of clearing away heat and dispelling stagnation, which is prepared from the following raw materials in parts by weight: 1500 parts of Senecio, 240 parts of licorice, and 40 parts of mint.

[0050] The method for preparing the above-mentioned Chinese medicine composition is basically the same as steps 1) to 5) in Example 1, except that:

[0051] 1) The concentration of ethanol is 70%, at 75 o C reflux extraction for 5 hours, also containing the sulfuric acid that the concentration of 1% by volume fraction is 98% in ethanol;

[0052] 2) 25 o At C, the relative density of thick paste 1 is 1.15;

[0053] 3) Sonicate for 10 minutes, 25 o When C, the relative density of thick paste 2 is 1.10;

[0054] 4) Set aside for 12 hours, 80 o When C, the relative density of thick paste 3 is 1.30;

[0055] 5) The extract of the traditional Chinese medicine composition is obtained after combining thick cream 1 and thick crea...

Embodiment 3

[0057] A traditional Chinese medicine composition with heat-clearing and stagnation-clearing functions, which is prepared from the following raw materials in parts by weight: 1000 parts of Senecio, 200 parts of licorice, and 40 parts of peppermint.

[0058] The method for preparing the above-mentioned Chinese medicine composition is basically the same as steps 1) to 5) in Example 1, except that:

[0059] 1) The concentration of ethanol is 55%, at 85 o C reflux extraction 4 hours, also containing volume fraction in ethanol is that the concentration of 3% is the nitric acid of 45%;

[0060] 2) Add ethyl acetate equivalent to 1 times its volume to the filtrate;

[0061] 3) Sonicate for 20 minutes, decoct once, and decoct for 3 hours;

[0062] 4) Adding the concentration equivalent to 1.1 times of its weight in the thick paste 2 is 90% ethanol;

[0063] 5) The extract of the traditional Chinese medicine composition is obtained after combining thick cream 1 and thick cream 3 . ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition with functions of clearing heat and removing stasis, a preparation and a method for preparing the traditional Chinese medicine composition and the preparation. The traditional Chinese medicine composition comprises, by weight, 1000-3000 parts of senecio scandens, 200-450 parts of radix glycyrrhizae and 40-60 parts of mentha haplocalyx. The preparation is a granule or capsule or tablet with the traditional Chinese medicine composition and pharmaceutically acceptable excipients. The compound heat clearing and stasis removing granule or capsule with the traditional Chinese medicine composition comprises, by weight, 1000-3000 parts of senecio scandens, 200-450 parts of radix glycyrrhizae, 40-60 parts of mentha haplocalyx, 58-200 parts of diluents, 10-50 parts of lubricants and 5-20 parts of binders. The traditional Chinese medicine composition, the preparation and the method have the advantages that the traditional Chinese medicine composition and the preparation do not need to be used with other medicines, are good in efficacy and can become effective fast; the contents of medicine toxic ingredients can be reduced by the aid of the method for preparing the traditional Chinese medicine composition and the preparation, the contents of effective ingredients can be increased, and the preparation time can be shortened.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition, a preparation and a preparation method thereof with functions of clearing heat and dispelling stagnation. Background technique [0002] Heat-clearing and stagnation-relieving medicine has the effects of anti-inflammatory, detoxification, stagnation-dispelling and pain-relieving. It is a broad-spectrum sterilizing and disinfecting drug, which can be used for acute conjunctivitis, acute pharyngitis, acute tonsillitis, acute enteritis, acute bacillary dysentery, upper respiratory tract inflammation, Treatment of acute bronchitis, lymphadenitis, sores and boils, otitis media, dermatitis and eczema. [0003] The main forms of the agent currently on the market include Qingre Sanjie Tablets and Qingre Sanjie Capsules. The properties of Qingre Sanjie Capsules included in the "Chinese Pharmacopoeia"...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/534A61K9/48A61K9/16A61K9/20A61P31/04A61P29/00A61P17/04A61P11/00
CPCA61K9/1652A61K9/2059A61K9/4866A61K36/28A61K36/484A61K36/534A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2236/55A61K2300/00
Inventor 肖军平吴永忠杨伟庆康兴东周朝忠
Owner JIANGXI POZIN PHARMA
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