Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation process of product no-load preventing doxycycline hydrochloride for injection

A technology of doxycycline hydrochloride and preparation process, applied in the field of medicine, can solve the problems of incapability of product control, inability to monitor the preparation process, slow dissolution speed, etc., and achieve the effect of improving the dissolution speed

Inactive Publication Date: 2016-03-09
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a preparation process of doxycycline hydrochloride for injection that avoids empty loading of the product, so as to overcome the slow dissolution rate of the existing doxycycline hydrochloride preparation in the preparation process and the incapability of real-time adjustment of the preparation process. Problems of monitoring and inability to effectively control the product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation process of product no-load preventing doxycycline hydrochloride for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Such as figure 1 Shown, avoid the preparation technology of the injection doxycycline hydrochloride of empty product, comprise the following steps:

[0025] 1) Preparation of doxycycline hydrochloride: Grind 5 g of doxycycline hydrochloride into powder with a ball mill, then dissolve the powder in water to form solution A; the percentage of doxycycline in the doxycycline hydrochloride The component content is 15%; Dissolve 10g of ethyl cellulose in ethanol to prepare solution B; under the premise of stirring, gradually pour solution A into solution B, and solution A will form emulsion C after solution B is dispersed; gelatin Dissolve in distilled water in a 60°C water bath to make protection solution D, keep the temperature at 30°C for use; add emulsion C dropwise to protection solution D under stirring to form solution E, raise the water bath from 30°C to 50°C, and stir The organic solvent is volatilized; then E is suction-filtered and washed with water to obtain a do...

Embodiment 2

[0030] like figure 1 Shown, avoid the preparation technology of the injection doxycycline hydrochloride of empty product, comprise the following steps:

[0031] 1) Preparation of doxycycline hydrochloride: Grind 5 g of doxycycline hydrochloride into powder with a ball mill, then dissolve the powder in water to form solution A; the percentage of doxycycline in the doxycycline hydrochloride The content is 20%; Dissolve 15g of ethyl cellulose in ethylene glycol to form solution B; under the premise of stirring, gradually pour solution A into solution B, and solution A forms emulsion C after solution B is dispersed; Dissolve gelatin and distilled water in an 80°C water bath to make protection solution D, keep the temperature at 30°C for use; add emulsion C dropwise to protection solution D under stirring to form solution E, and raise the water bath from 30°C to 50°C , stirred to volatilize the organic solvent, then E was suction filtered and washed to obtain a doxycycline hydroch...

Embodiment 3

[0036] like figure 1 Shown, avoid the preparation technology of the injection doxycycline hydrochloride of empty product, comprise the following steps:

[0037] 1) Preparation of doxycycline hydrochloride: Grind 6 g of doxycycline hydrochloride into powder with a ball mill, then dissolve the powder in water to form solution A; the percentage of doxycycline in the doxycycline hydrochloride The content is 25%; Dissolve 12g of ethyl cellulose in dichloromethane to configure solution B; under the premise of stirring, gradually pour solution A into solution B, and solution A forms emulsion C after solution B is dispersed; Dissolve gelatin and distilled water in a 70°C water bath to make protection solution D, keep the temperature at 30°C for use; add emulsion C dropwise to protection solution D under stirring to form solution E, and raise the water bath from 30°C to 50°C , stirring to volatilize the organic solvent; then E is suction filtered and washed to obtain a doxycycline hyd...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation process of product no-load preventing doxycycline hydrochloride for injection. The preparation process comprises the following steps: grinding doxycycline hydrochloride into powder by using a ball mill and dissolving the powder in water to prepare a solution A; dissolving ethyecellulose in an organic solvent to prepare a solution B; gradually pouring the solution A in the solution B with stirring, wherein the solution A is dispersed in the solution B to form an emulsion C; dissolving gelatin in distilled water in a water bath at 60-80 DEG C to prepare a protection solution D, and keeping the protection solution at a constant temperature of 30 DEG C for after use; dropwise adding the emulsion C into the protection solution D with stirring to form a solution E, warming the water bath from 30 DEG C to 50 DEG C, and stirring the solution E to volatilize the organic solvent; and carrying out suction filtration, water washing and drying on the solution E to obtain white powdered doxycycline hydrochloride. The preparation method is capable of solving the problems that the existing doxycycline hydrochloride preparation is relatively low in dissolution speed, the preparation process cannot be monitored in real time and the product cannot be effectively controlled.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation process of doxycycline hydrochloride for injection which avoids empty loading of the product. Background technique [0002] Doxycycline hydrochloride is a broad-spectrum semi-synthetic tetracycline antibiotic. Its antibacterial spectrum is similar to that of tetracycline, but its antibacterial effect is 10 times stronger. The medicine has strong water solubility, good absorption and wide distribution, and has many clinical applications and good effects. Microorganisms have close cross-resistance to this drug and tetracycline, oxytetracycline, etc. Oral absorption is good. It is mainly used for upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellulitis, etc. caused by sensitive gram-positive bacteria and gram-negative bacilli. wait. It can still be used to treat cholera, and also to prevent falciparum malaria and leptospir...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/24C07C237/26
CPCC07C231/24
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com