Medicine use control system of large-dosage methotrexate

A methotrexate, high-dose technology, applied in the field of clinical medical treatment, can solve the problems of many blood collection times, poor popularization, increased pain of children and family economic burden, etc., and achieves the effect of ensuring the course of treatment and reducing the effect of poisoning

Inactive Publication Date: 2016-04-06
PEKING UNIV FIRST HOSPITAL
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Problems solved by technology

[0005] The purpose of the present invention is to provide a large-dose methotrexate medication control system, which solves the problems in the prior art that increase the pain of children and the economic burden of families due to the large number of blood collections in the adjustment process, and the problem of poor popularization

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  • Medicine use control system of large-dosage methotrexate
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  • Medicine use control system of large-dosage methotrexate

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Embodiment Construction

[0045] The preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described below are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0046] figure 1 It is a schematic diagram of a large-dose methotrexate medication control system provided by the embodiment of the present invention, as shown in figure 1 As shown, it includes: a methotrexate initial concentration determination device 101, which is used to determine the initial methotrexate concentration in the methotrexate infusion solution according to the patient's body surface area; a methotrexate blood drug concentration detection device 102, It is used to detect the methotrexate plasma concentration of the patient at any time of 6-10 hours when the methotrexate infusion solution is infused into the patient's body; the methotrexate i...

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Abstract

The invention discloses a medicine use control system of large-dosage methotrexate, and relates to the technical field of clinical medical treatment. The medicine use control system comprises a methotrexate initial concentration determining device, a methotrexate plasma concentration detection device and a plasma concentration input regulation device. The methotrexate initial concentration determining device is used for determining the initial methotrexate concentration in methotrexate concentration input liquid according to the body surface area of a patient. The methotrexate plasma concentration detection device is used for detecting the methotrexate plasma concentration of the patient at any moment in the 6-10 hours during which the methotrexate input liquid is infused into the patient. The methotrexate input regulation device is used for regulating the methotrexate concentration in the methotrexate input liquid or the input speed according to the detected methotrexate plasma concentration. The medicine use amount is regulated according to the plasma concentration in the 6-10 hours after HDMTX infusion is conducted on the patient, and therefore Css of 90% or above of patients and treatment courses can reach the effective concentration, the treatment courses are ensured, and toxic and side effects are relieved.

Description

technical field [0001] The invention relates to the technical field of clinical medicine, in particular to a large-dose methotrexate medication control system. Background technique [0002] High-dose MTX (Methotrexate, methotrexate) is used to treat children with acute lymphoblastic leukemia. It has been widely used in clinical practice at home and abroad as early as more than 20 years ago. Treatment of Hodgkin's lymphoma. At present, 24-hour continuous intravenous infusion of high-dose methotrexate combined with tetrahydrofolic acid rescue has been proven to be one of the most effective chemotherapy regimens for children with acute lymphoblastic leukemia. Its combination with intrathecal injection has replaced cranial radiotherapy and has become a new treatment for central nervous system leukemia. A must for prevention and treatment. [0003] Leukemia patients need multiple applications of high-dose methotrexate chemotherapy, and the therapeutic effect of each high-dose m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/14
CPCA61M5/14A61M2202/0007A61M2202/04
Inventor 赵卫红华瑛卢新天谢瑶杨丽华卢炜
Owner PEKING UNIV FIRST HOSPITAL
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