10results about How to "Reduce toxic effects" patented technology

The invention discloses a multi-nutrition-level ecological breeding system suitable for freshwater fish breeding, and belongs to the technical field of ecological breeding. The ecological breeding system is provided with a plurality of nutrition levels, the nutrition levels at least comprise a fish nutrition level, a filter-feeding shellfish nutrition level and a benthic organism nutrition level, the ecological breeding system further comprises submerged plants, and the ecological breeding system is characterized in that the bottom layer of the ecological breeding system is the benthic organism nutrition level, and the bottom layer of the ecological breeding system is the filter-feeding shellfish nutrition level. The benthic organism nutrition level comprises ecological concrete and biochar, the biochar provides a habitat for benthic organisms, the ecological concrete provides an activity space for the benthic organisms, and submerged plants are fixed by a porous structure of the ecological concrete. According to the multi-nutrition-level ecological breeding system suitable for freshwater fish breeding, organic matter pollutants and heavy metal in sediments at the water bottom can be effectively removed, the stability of the sediments is improved, and resuspension of the organic matter pollutants, caused by water flow disturbance, of the sediments is reduced.

The invention discloses a method for evaluating combined toxicity of nano plastic and tamoxifen based on caenorhabditis elegans and a method for resisting drug toxicity caused by the nano plastic, a sample to be detected is an NGM solid culture medium of a mixture of the nano plastic and tamoxifen, and the caenorhabditis elegans is inoculated into the sample to be detected. The toxic effect of the joint exposure of the nano plastic and the tamoxifen on nematode movement, nerve, development and reproduction under the actual environment condition can be quickly and accurately evaluated, and a basis is provided for evaluation of human health risks. The invention provides a combined toxicity detection method which is suitable for laboratories, simple and convenient to operate and high in applicability by fully considering the problems that the toxicity is changed due to the chemical effect generated by nano-plastics and medicines and the in-vivo conditions are complicated and are difficult to observe, and provides a combined toxicity detection method which is suitable for laboratories and can be used for detecting the toxicity by supplementing N-acetylcysteine through diet. The effect of N-acetylcysteine in relieving tamoxifen toxicity caused by nano-plastics is further evaluated.

The invention relates to the technical field of biological tissue transparentizing, in particular to a remote biological tissue transparentizing system and method. The remote biological tissue transparentizing system comprises: a sample cell for accommodating biological tissue; the liquid storage bottle is used for containing a reagent; a pump for pumping the reagent; a first conduit for connecting the sample cell and the pump; the second guide pipe is used for connecting the pump and the liquid storage bottle, and an electromagnetic valve and a flow meter are arranged on the second guide pipe; the PLC is electrically connected with the electromagnetic valve, the flow meter and the pump, and the PLC is used for obtaining flow data from the flow meter and controlling the electromagnetic valve and the pump; and the remote operation system is connected with the PLC and is used for remotely controlling the PLC. By means of the remote biological tissue transparentizing system, biological tissue transparentizing can be achieved remotely.

The invention relates to a method for reducing the toxicity of nano-zinc oxide in anaerobic sludge by using polyferric sulfate (PFS), which belongs to the technical field of novel pollutant environmental protection, and mainly comprises the following steps: the polyferric sulfate (PFS) is used as a coagulant commonly used for sewage treatment, is simple and easy to obtain, and is relatively low in cost; the PFS can reduce the toxic influence of nZnO on anaerobic digestion of the sludge by generating a low-toxicity soluble Zn complex, improve the methane production performance under the stress of nZnO, and provide technical support and guidance for toxicity control in the anaerobic digestion process of the sludge; the invention aims to promote anaerobic digestion of sludge to further become an efficient sludge treatment technology which synchronously realizes sludge stabilization and resource recovery, is low in treatment cost and is convenient for actual operation.

The invention discloses a novel nanoparticle drug delivery system for targeted therapy of TNBC, and relates to the technical field of targeted inhibition and treatment of TNBC. According to the novel nanoparticle drug delivery system for targeted therapy of TNBC, the preparation method of the novel nanoparticle drug delivery system comprises the following specific steps: S1, synthesizing; the preparation method comprises the following steps: synthesizing B I-PEG-COOH and B I-PEG-PTX with tumor targeting capability; s2, material characterization; using Fourier transform infrared spectroscopy and 1HNMR to verify the structural characteristics of the B I-PEG-COOH and B I-PEG-PTX samples obtained in the step S1; s3, preparing a nano-micelle; and after the verification is passed, preparing the nano-micelles BBR (at) PTX NPs according to the B I-PEG-COOH and the B I-PEG-PTX obtained in the step S1. According to the invention, the nanocluster has a targeting capability, and chemotherapeutic drugs flowing to normal tissues are reduced, so that the toxic influence on the normal tissues is reduced, the dual drug delivery system is beneficial to increase of the tumor targeting capability, novel high-efficiency and low-toxicity nano treatment is realized, and the application prospect is wide. And a further optimized strategy is provided for clinical chemotherapy sensitization of a nanoparticle drug delivery system.

The invention belongs to the field of pressure-sensitive adhesives, and discloses a root inhibitor modified filler, a butyl pressure-sensitive adhesive, and a preparation method and application of the butyl pressure-sensitive adhesive. The root inhibitor modified filler is prepared by stirring a layered double hydroxide composition and a root inhibitor in the presence of a solvent; the chemical structural formula of the layered double hydroxide composition is # imgabs0 #, wherein M < 2 + > is at least one of Mg < 2 + >, Zn < 2 + >, Ni < 2 + >, Co < 2 + > and Mn < 2 + >; m < 3 + > is at least one of Al < 3 + >, Ga < 3 + >, Fe < 3 + > and Mn < 3 + >; an <-> is at least one of F <->, CO3 < 2->, Cl <->, SO4 < 2-> and organic acid ions; x ranges from 0.2 to 0.4, and the root inhibitor is a micromolecular chemical root inhibitor. According to the invention, a novel powder material is introduced and is modified by using the root inhibitor, so that the obtained root inhibitor modified filler not only has a better dispersion condition in the butyl pressure-sensitive adhesive, but also has the performance of slowly releasing the root inhibitor.

The present application relates to the technical field of fluorescent probe, and discloses a fluorescent probe locked by viscosity and glycosidase, and a preparation method and application thereof.The present application provides a compound, the fluorescence emission intensity of which is enhanced with the enhancement of the solution viscosity; meanwhile, after incubation with beta-galactosidase, the fluorescence intensity of the compound at 640nm is enhanced.Therefore, in the early diagnosis imaging of ovarian cancer, the compound can be used as a fluorescent probe locked by viscosity and glycosidase, and is used for accurate imaging of ovarian cancer.The fluorescent probe of the present application greatly improves the selectivity of the probe by using a double activation mechanism, effectively avoids non-specific activation to normal tissues, and is particularly suitable for targeted imaging of specific pathological environments such as tumors.

The invention provides a manioc waste liquid feed preparation process based on microbial fermentation, and belongs to the technical field of feed. According to the application, the nano calcium phosphate loaded high-valence ferric salt and the metal ion doped hydroxyapatite are introduced to solve the problems of excessive metal ions and anti-nutrient substance residues; the nano calcium phosphate loaded high-valence ferric salt efficiently oxidizes and removes cyanide ions and tannin in the fermentation liquor through ferrate loaded on the surface; oxidation products and part of ferric ions are fixed, so that inhibition on microorganisms is avoided; the metal ion-doped hydroxyapatite effectively captures excessive metal ions through ion exchange and complexation, reduces the free concentration of the metal ions, prevents adverse effects on microbial metabolism, can compete with anions in a fermentation liquid, inhibits the generation of toxic complexes, and reduces the toxicity to a fermentation system; the synergistic effect of removal of anti-nutrient substances and dynamic regulation and control of metal ions is achieved, and the nutritional value and safety of the final feed are improved.

The application discloses a method for promoting bacteria to degrade benzene[a]pyrene by using tea residue fermentation liquor and application thereof. The method comprises the following steps: adding the tea residue fermentation liquor into an environment containing benzene[a]pyrene, and promoting the microorganisms in the environment to degrade the benzene[a]pyrene. Under the stimulation of the tea residue fermentation liquor, the degradation effect of the bacteria in the environment on the benzene[a]pyrene is significantly improved, and the stimulation efficiency is 212.6%. The tea residue fermentation liquor is simple to make, low in production cost and convenient to obtain, and can quickly repair the polluted environment.

The present application relates to the field of bioengineering, and particularly relates to a mutant of mu-conotoxin and a preparation method and an enzyme composition thereof.The present application provides a mutant of mu-conotoxin, which has an amino acid sequence as shown in SEQ ID NO:1, or an amino acid sequence obtained by substituting, deleting or adding one or more amino acids in the amino acid sequence, and an amino acid sequence which is functionally identical or similar to the amino acid sequence, or an amino acid sequence which is at least 80% identical to the amino acid sequence.The technical route and process provided by the present application greatly improve the production efficiency and quality of mu-conotoxin, are suitable for industrial large-scale production, and have a wide application prospect.