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Extraction method and application of red peony synergy whitening extractive

An extraction method and extraction technology, which is applied in the field of extraction and separation of traditional Chinese medicine products, can solve the problem of high content of impurities such as pigments, and achieve the effect of improving the whitening effect

Active Publication Date: 2016-04-20
GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the present invention provides a method for extracting the synergistic whitening extract of Radix Paeoniae Rubra, the product obtained through the extraction method can effectively solve the problem of high content of impurities such as pigments, and at the same time effectively improve the whitening effect of the product

Method used

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  • Extraction method and application of red peony synergy whitening extractive
  • Extraction method and application of red peony synergy whitening extractive
  • Extraction method and application of red peony synergy whitening extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 100 grams of Radix Paeoniae Rubra powder with a particle size of 24 mesh, heat it in 1200 mL of deionized water under reflux at 80°C for 1 hour, then concentrate it at 70°C to a water content of 5%, to obtain the reference substance.

Embodiment 2

[0035] Weigh 100 grams of Radix Paeoniae Rubra powder with a particle size of 24 mesh, soak it in 1200 mL of 50% ethanol for 1 hour, and obtain the first product 1. The first product was heated under reflux in a water bath at 80° C. for 0.5 h to obtain the second product 1 . The second product was concentrated to a water content of 5% at 170°C to obtain the third product 1. The third product 1 was dissolved in 200 mL of deionized water to obtain the fourth product 1. The fourth product 1 was centrifuged at 3000 r / min for 30 min, and the supernatant was collected to obtain the fifth product 1. Get 100mL of the fifth product 1 to flow through the diameter-to-height ratio of 1:9, after the volume is absorbed by the D101 type macroporous resin chromatography column of 100mL, rinse the macroporous resin with 400mL deionized water, and finally use 300mL volume concentration of 65% Ethanol solution was used for elution, and the eluate was collected to obtain product 1. The flow ra...

Embodiment 3

[0037] Weigh 100 grams of Radix Paeoniae Rubra powder with a particle size of 24 mesh, soak it in 1200 mL of 70% ethanol for 1 hour, and obtain the first product 2. The first product was heated under reflux in a water bath at 80° C. for 0.5 h to obtain the second product 2 . The second product was concentrated to a water content of 5% at 270°C to obtain the third product 2. The third product 2 was dissolved in 200 mL of deionized water to obtain the fourth product 2. The fourth product 2 was centrifuged at 3000 r / min for 30 min, and the supernatant was collected to obtain the fifth product 2. After 100mL of the fifth product 2 flowed through the diameter-to-height ratio of 1:9 and the volume was adsorbed by the D101 type macroporous resin chromatography column of 100mL, the macroporous resin was washed with 400mL deionized water, and finally 300mL of 65% volume concentration was used. Ethanol solution was used for elution, and the eluate was collected to obtain product 2. T...

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Abstract

The invention belongs to the field of traditional Chinese medicine product extraction and separation, particularly relates to an extraction method and application of a red peony synergy whitening extractive, and is used for solving the problems of high content of impurities including pigment and the like and poor whitening effect since the traditional whitening cosmetics in which traditional Chinese medicine extractives are added are generally prepared from traditional Chinese medicine crude extractives. The extraction method of the red peony synergy whitening extractive comprises the following steps: dipping, and carrying out alcohol extraction, concentration, centrifugation and purification to obtain the product. The product contains seven peony monoterpenoid glycoside compounds and four flavonoid compounds, wherein the seven peony monoterpenoid glycoside compounds consist of paeoniflorin sulfurous ester, oxypaeoniflorin, albiflorin std, paeoniflorin, galloyl paeoniflorin, benzoyloxy paeoniflorin and benzoylpaeoniflorin, and the four flavonoid compounds consist of catechinic acid, dihydroquercetin, astragalin and naringenin. The product has a tyrosinase inhibition function, a blood activation function and an oxidation resistance function, and possesses the characteristics of traditional Chinese medicine cosmetic which has a diversity of functional components performing a synergy whitening function.

Description

technical field [0001] The invention belongs to the field of extraction and separation of traditional Chinese medicine products, and in particular relates to an extraction method and application of a synergistic whitening extract of Radix Paeoniae Rubra. Background technique [0002] Because traditional Chinese medicine has the characteristics of low toxicity and safety, multi-component and multi-target, it has become the focus of attention in the development of whitening cosmetics. The current traditional Chinese medicine whitening cosmetics mainly have the following problems: (1) the so-called traditional Chinese medicine cosmetics on the market have no real name, Only a small amount or no traditional Chinese medicine ingredients are added symbolically; (2) It can only be regarded as a cosmetic with added plant ingredients, which does not reflect the comprehensive effect of Chinese medicine with multiple ingredients and multiple targets; (3) Cosmetics containing Chinese med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K36/65A61K36/71A61Q19/02A61Q19/08A61P7/02A61P39/06
CPCA61K8/97A61K36/65A61K36/71A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61Q19/02A61Q19/08
Inventor 龙晓英陆颂规彭红英陈志雄陈永钧潘素静
Owner GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARM CO LTD
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