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Andrographolide dry suspension prepared by melt spraying and preparation method thereof

A technology of andrographolide and dry suspension is applied in directions such as medical preparations, antiviral agents, and pharmaceutical formulations containing active ingredients, and can solve the problems of andrographolide having a bitter taste, being insoluble in water, and unfavorable for patients to take medicine. , to achieve the effect of good taste, no bitterness and convenient taking.

Active Publication Date: 2018-07-27
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, andrographolide has developed common dosage forms such as tablets, capsules, and dripping pills. However, diterpenoid lactone compounds are difficult to dissolve in water and can only be administered orally
In addition, due to the extremely bitter taste of andrographolide, it is unfavorable for children, the elderly and patients with dysphagia to take medicine. These dosage forms have not solved this problem

Method used

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  • Andrographolide dry suspension prepared by melt spraying and preparation method thereof
  • Andrographolide dry suspension prepared by melt spraying and preparation method thereof
  • Andrographolide dry suspension prepared by melt spraying and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 15g of cetyl alcohol and stearyl alcohol in a beaker, heat the beaker in a water bath at 85°C, add 10g of andrographolide after it melts, and stir for 30 minutes with a magnetic stirrer, so that the andrographolide is mixed with the mixture After suspending in stearyl alcohol, it is sprayed with hot melt.

[0043] The melt spray parameters are: air inlet temperature 130°C, atomization pressure 0.3Kpa, feed rate 80ml / min.

[0044] The hot-melt spray product is collected to obtain the flavored mixture of andrographolide. The mixture is mixed with fillers, flavors, sweeteners, sour agents and suspending agents in appropriate proportions to obtain the andrographolide dry suspension.

[0045] The prescription of andrographolide dry suspension is as follows:

[0046] Mixture of andrographolide, cetyl alcohol and stearyl alcohol: 4g

[0047] Lactose: 15.3g

[0048] Xanthan gum: 0.1g

[0049] Micropowder silica gel: 0.05g

[0050] Neotame: 0.2g

[0051] Sweet orange...

Embodiment 2

[0056]Take 15g of glyceryl monostearate and glyceryl behenate in a beaker, seal with plastic wrap, heat the beaker in a water bath at 85°C, after it melts, add 10g of andrographolide, and use a magnetic stirrer After stirring for 30 minutes, the andrographolide was suspended in stearyl alcohol, and then hot-melt sprayed.

[0057] The prescription of andrographolide dry suspension is as follows:

[0058] Mixture of andrographolide with glyceryl monostearate and glyceryl behenate: 4g

[0059] Starch: 15.3g

[0060] Xanthan gum: 0.1g

[0061] Micropowder silica gel: 0.05g

[0062] Neotame: 0.2g

[0063] Sweet orange essence: 0.2g

[0064] Citric acid: 0.2g

[0065] The melt spray parameters are: air inlet temperature 130°C, atomization pressure 0.3Kpa, feed rate 80ml / min.

[0066] The hot-melt spray product is collected to obtain the flavored mixture of andrographolide. . The mixture is mixed with fillers, flavors, sweeteners, sour agents and suspending agents in appropr...

Embodiment 3

[0070] Take 10g of stearyl alcohol and 10g of glyceryl monostearate in a beaker, seal it with plastic wrap, heat the beaker in a water bath at 85°C, after it melts, add 10g of andrographolide, and stir with a magnetic stirrer for 30 Minutes, so that the andrographolide was suspended in stearyl alcohol, and then hot-melt sprayed.

[0071] The melt spray parameters are: air inlet temperature 130°C, atomization pressure 0.3Kpa, feed rate 50ml / min.

[0072] The hot-melt spray product is collected to obtain the flavored mixture of andrographolide. The mixture is mixed with fillers, flavors, sweeteners, sour agents and suspending agents in appropriate proportions to obtain the andrographolide dry suspension.

[0073] The prescription of andrographolide dry suspension is as follows:

[0074] Mixture of andrographolide with stearate and glyceryl monostearate: 4g

[0075] Lactose: 15.3g

[0076] Sodium alginate: 0.1g

[0077] Micropowder silica gel: 0.05g

[0078] Neotame: 0.2g ...

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Abstract

The invention discloses an andrographolide dry suspension which is particles prepared from andrographolide and accessories by mixing and spraying, wherein the accessories have relatively low melting points and are any two of hexadecanol, octadecanol, glyceryl monostearate, glyceryl behenate, stearic acid, beewax, polyvinyl alcohol and polyethylene glycol; the total mass of the accessories with relatively low melting points is 0.1-10 times that of andrographolide; and the accessories also include at least one other accessory. The andrographolide dry suspension disclosed by the invention is convenient to take simply by adding a little water; and with little bitterness, the andrographolide dry suspension realizes a good taste modifying effect on andrographolide and is suitable for children, old people and patients suffering dysphagia.

Description

Technical field: [0001] The invention relates to a dry suspension of andrographolide and a preparation method thereof. Background technique: [0002] Whether it is a chemical medicine or a traditional Chinese medicine, the bitter taste of the medicine is one of the reasons why it is not accepted by people. Andrographolide is a diterpene lactone compound, which has the effects of dispelling heat and detoxification, reducing inflammation and relieving pain, and is effective against bacteria and viruses. It has a special curative effect on upper respiratory tract infection and dysentery, and is known as a natural antibiotic drug. In recent years, andrographolide has been developed into common dosage forms such as tablets, capsules, and dripping pills. However, diterpenoid lactone compounds are difficult to dissolve in water and can only be administered orally. In addition, because the taste of andrographolide is extremely bitter, it is unfavorable for children, the elderly and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/365A61P31/04A61P31/12A61P11/00A61P1/12
CPCA61K9/1617A61K9/1652A61K31/365
Inventor 罗晓健欧阳婷杨小玲吕武清简辉崔刚刘地发饶小勇张尧刘艳红殷华峰胡晓强田佳明汤新乾
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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