Pharmaceutical composition of ciclopirox olamine and medical application of pharmaceutical composition

A technology of ciclopirox amine and composition, which is applied in the directions of drug combination, metabolic diseases, urinary system diseases, etc., can solve the problems such as no reports related to ciclopirox amine cardiomyopathy, and achieves outstanding substantive characteristics and strong effect. , the effect of significant improvement

Inactive Publication Date: 2016-06-29
吴珺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between ciclopirox olamine and its pharmaceutical composition and diabetic cardiomyopathy

Method used

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  • Pharmaceutical composition of ciclopirox olamine and medical application of pharmaceutical composition
  • Pharmaceutical composition of ciclopirox olamine and medical application of pharmaceutical composition
  • Pharmaceutical composition of ciclopirox olamine and medical application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) Crush asters (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) , ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) Use D101 macroporous resin to remove impurities from the n-butanol extract, first elute with 10% ethanol for 8 column volumes, then use 70% ethanol for 10 column volumes, collect 70% eluate, and concentrate unde...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] 40 Wistar rats aged 3 to 4 months, half male and half male, weighing 210 g to 250 g, were provided by the Experimental Animal Center of Jiamusi University. The animals were kept in a ventilated and dry environment with a temperature of (22±1)°C, a relative humidity of 55%-65%, and a 12-h light cycle, and were fed with maintenance diet 1022 for rats and mice.

[0029] 1.2 Reagents and samples

[0030] Ciclopirox was purchased from China National Institutes for Food and Drug Control. Compound (I) is self-made, and the preparation method is shown in Example 1. Streptozotocin (STZ) was purchased from Sigma Company of the United States; SOD, Coomassie Brilliant Blue protein assay kits were purchased from Nanjing Jiancheng Bioengineering Institute. Triglyceride kit was purchased from Changchun Huili Engineering Technology Development Center.

[0031] 1.3 Instruments

[...

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Abstract

The present invention discloses a pharmaceutical composition of ciclopirox olamine and its medical application. The pharmaceutical composition of ciclopirox olamine provided by the present invention contains ciclopirox olamine and a natural product compound (I) with a novel structure. Ciclopirox olamine and compound (Ⅰ) can protect the activity of antioxidant enzymes in rats, scavenge free radicals, and inhibit lipid peroxidation, suggesting that anti-oxidation is the mechanism by which ciclopirox olamine and compound (Ⅰ) protect the kidneys of DM rats one. After the combined use of ciclopirox olamine and compound (I), the blood lipid regulation and renal protection effects on rats with type 2 diabetes are further improved, and early application can effectively delay the occurrence and development of diabetic nephropathy, and can be developed into a treatment for diabetic nephropathy. The drug for pathological changes has outstanding substantive features and significant progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of ciclopirox olamine, in particular to a pharmaceutical composition of ciclopirox olamine and its medical application. Background technique [0002] Ciclopirox olamine is a broad-spectrum antifungal drug, mainly by changing the integrity of the fungal cell membrane, causing the outflow of intracellular substances, and blocking the uptake of protein precursor substances, resulting in the death of fungal cells. It has strong antibacterial and bactericidal effects and strong permeability. It also has a certain inhibitory effect on various actinomycetes, gram-positive and gram-negative bacteria, mycoplasma, chlamydia, and trichomonas. [0003] So far, there has been no report on the correlation between ciclopirox olamine and its pharmaceutical composition and diabetic cardiomyopathy. Contents of the invention [0004] The object of the present invention is to provide a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/06A61K31/4412A61K31/366A61P3/10A61P13/12
CPCC07D407/06A61K31/366A61K31/4412
Inventor 吴珺
Owner 吴珺
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