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Oral chemotherapy tablets for treating gastric cancer

A technology for tablets and gastric cancer, which is applied in the field of oral chemotherapy tablets for the treatment of gastric cancer, can solve the problems of easily causing dehydration, cardiotoxicity, hindering popularization and use, and achieves good killing of tumor cells, reducing toxicity, improving hardness and disintegration. performance effect

Inactive Publication Date: 2016-07-06
QINGDAO HUANGDAO HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Xeloda (capecitabine tablets) is the main oral chemotherapy drug on the market, but its further popularization is hindered by its limitations such as cardiotoxicity and easy dehydration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An oral chemotherapy tablet for the treatment of gastric cancer, consisting of the following components: capecitabine 58.6mg, cisplatin liposome 17.9mg, oteracil potassium 20.4mg, hydrous lactose 4.6mg, magnesium stearate 2.8mg , Microcrystalline cellulose 3.3mg, pregelatinized starch 4.2mg, starch 38.2mg.

Embodiment 2

[0023] An oral chemotherapy tablet for the treatment of gastric cancer, consisting of the following components: 55 mg capecitabine, 19.5 mg cisplatin liposome, 16.2 mg oteracil potassium, 35.2 mg aqueous lactose, 2.5 mg magnesium stearate, Microcrystalline cellulose 4.2mg, pregelatinized starch 3.7mg, starch 13.7mg.

Embodiment 3

[0025] An oral chemotherapy tablet for treating gastric cancer, consisting of the following components: 79 mg capecitabine, 15.8 mg cisplatin liposome, 22.4 mg oteracil potassium, 3.4 mg aqueous lactose, 3.6 mg magnesium stearate, Microcrystalline cellulose 2.8mg, pregelatinized starch 4.6mg, starch 18.4mg.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to oral chemotherapy tablets for treating gastric cancer. The oral chemotherapy tablets are prepared from the following components by weight: 55-79 mg of capecitabine, 15.8-19.5 mg of Lipoplatin, 16.2-22.4 mg of potassium oxonate, 3.4-5.2 mg of water-containing lactose, 2.5-3.6 mg of magnesium stearate, 2.8-4.2 mg of microcrystalline cellulose, 3.7-4.6 mg of pregelatinized starch, the balance of starch, and the total weight of the components is 150 mg, wherein capecitabine, Lipoplatin and potassium oxonate are medicinal components. The oral chemotherapy tablets have the characteristics of being convenient to use, short in course of treatment, obvious in curative effects, and small in side effects.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to an oral chemotherapy tablet for treating gastric cancer. Background technique [0002] Gastric cancer ranks first among various malignant tumors in my country. Most patients with early gastric cancer have no obvious symptoms, and a few people have nausea, vomiting or upper gastrointestinal symptoms similar to ulcer disease. Pain and weight loss are the most common clinical symptoms of advanced gastric cancer. Patients often have relatively clear upper gastrointestinal symptoms, such as upper abdominal discomfort and fullness after eating. As the condition progresses, upper abdominal pain increases, appetite decreases, and fatigue develops. Patients with advanced gastric cancer often experience symptoms such as anemia, weight loss, malnutrition and even cachexia. [0003] For the treatment of gastric cancer, surgery or chemotherapy is mainly used. However, the methods of sur...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K9/20A61K47/38A61K47/36A61K47/26A61P35/00A61K31/7068A61K31/53
Inventor 卢彦敏
Owner QINGDAO HUANGDAO HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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