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Medicine composition of amiodarone hydrochloride and application thereof in biological medicine

A technology of amiodarone hydrochloride and its composition, which is applied in the field of pharmaceutical composition and its application in biomedicine, can solve the problems that there are no related reports on amiodarone hydrochloride and its pharmaceutical composition, and improve the effect of cough relief Effect

Inactive Publication Date: 2016-07-13
徐玉仙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between amiodarone hydrochloride and its pharmaceutical composition and cough relief

Method used

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  • Medicine composition of amiodarone hydrochloride and application thereof in biological medicine
  • Medicine composition of amiodarone hydrochloride and application thereof in biological medicine
  • Medicine composition of amiodarone hydrochloride and application thereof in biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0020] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0021] Separation method: (a) Grind the dried rhizome (2kg) of Acorus calamus, extract with 90% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until there is no alcohol smell (4L), and then use petroleum ether (4L ×3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In the step (a), the n-butanol extract is removed with AB-8 macroporous resin, first eluted with 8% ethanol for 10 column volumes, then with 70% ethanol for 12 column volumes, and collected 7...

Embodiment 2

[0024] Embodiment 2: pharmacological action

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] KM mice, SPF grade, half male and half male, weighing 18-22 g, were provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences. Experimental animal facility conditions: Animal Observation Room, School of Pharmacy, Chengdu University of Traditional Chinese Medicine.

[0028] 1.2 Reagents and samples

[0029] Amiodarone hydrochloride was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Concentrated ammonia water (analytical pure), produced by Chengdu Kelong Chemical Reagent Factory. NaHCO 3 (analytical pure), Chengdu Kelong Chemical Reagent Factory. Phenol red was produced by Shanghai Reagent No.3 Factory.

[0030] 1.3 Instruments

[0031] VARIOSKANFLASH2.4.3 full-wavelength multi-function readout instrument, produced by...

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Abstract

The invention discloses a medicine composition of amiodarone hydrochloride and application thereof in biological medicine.The medicine composition of amiodarone hydrochloride contains amiodarone hydrochloride and a natural product compound (I) which is separated from dry rhizomes of acorus gramineus and is novel in structure, and amiodarone hydrochloride and the compound (I) act separately, so that a treatment effect on cough is achieved; amiodarone hydrochloride and the compound (I) act together, the treatment effect on cough is better, and the medicine composition can be developed into medicine for treating the cough, has prominent substantive features and makes a remarkable progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of amiodarone hydrochloride, in particular to a pharmaceutical composition of amiodarone hydrochloride and its application in biomedicine. Background technique [0002] Amiodarone hydrochloride is an anti-anginal drug, which can selectively expand coronary blood flow, reduce myocardial oxygen consumption, slow down heart rate, and reduce atrioventricular conduction velocity, which is similar to the effect of β-blockers. For supraventricular and ventricular tachycardia, paroxysmal atrial flutter and fibrillation, pre-excitation syndrome, also for intractable paroxysmal tachycardia, chronic coronary insufficiency and angina pectoris. [0003] So far, there has been no report on the correlation between amiodarone hydrochloride and its pharmaceutical composition and cough relief. Contents of the invention [0004] The object of the present invention is to provide a pharma...

Claims

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Application Information

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IPC IPC(8): C07D317/70A61K31/36A61K31/343A61P11/14
CPCA61K31/343A61K31/36C07D317/70A61K2300/00
Inventor 徐玉仙
Owner 徐玉仙
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