Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of ulinastatin in preparation of drugs for treating esophageal cancer

A technology for ulinastatin and esophageal cancer, which is applied in the field of medicine to achieve the effects of low toxic and side effects, reduced expression, and reduced economic burden

Inactive Publication Date: 2016-07-20
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above published data show that ulinastatin has a good effect on the recovery of the body of patients with esophageal cancer after surgery, reducing postoperative complications and reducing the risk of surgery, but there is no relevant report showing that ulinastatin has a therapeutic effect on esophageal cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of ulinastatin in preparation of drugs for treating esophageal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, ulinastatin injection

[0018] Preparation method: Take 100 million units of ulinastatin aqueous solution sterilized by filtration, add 20 grams of mannitol to dissolve, add citrate buffer solution to adjust pH to neutral, add water for injection to 1000 ml, add sodium chloride to adjust isotonicity , sterile filtered, and packed in 500 vials.

Embodiment 2

[0019] Embodiment 2, ulinastatin injection

[0020] Preparation method: Take 100 million units of filtered sterilized ulinastatin aqueous solution, add 20 grams of mannitol to dissolve, add citrate buffer to adjust pH to neutral, add water for injection to 2000 ml, add sodium chloride to adjust isotonicity , sterile filtered, and packed in 1000 vials, to get final product.

Embodiment 3

[0021] Embodiment 3, ulinastatin injection

[0022] Preparation method: Take 100 million units of ulinastatin aqueous solution sterilized by filtration, add 20 grams of mannitol to dissolve, add citrate buffer solution to adjust pH to neutral, add water for injection to 4000 ml, add sodium chloride to adjust isotonicity , sterile filtered, and packed in 2000 vials, to get final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine and particularly discloses use of ulinastatin in the preparation of drugs for treating esophageal cancer. It is proved herein that by treating a nude mouse with esophageal cancer with ulinastatin, weight reduction of the nude mouse with esophageal cancer can be significantly reduced, dimensional increase of tumors can be significantly inhibited, the weight of esophageal cancer tumors can also be significantly reduced, and high tumor inhibition rate can be achieved; in addition, by increasing the expression of apoptosis-promoting protein Bax and apoptosis terminal cleavage enzyme caspase-3, ulinastatin can reduce the expression of anti-apoptotic protein Bcl-2, accelerate the apoptosis of tumor cells and finally resist esophageal cancer. Ulinastatin described herein causes little adverse response, is low in toxic and side effect, high in safety and low in cost, and is good in therapeutic effect for esophageal cancer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically discloses the use of ulinastatin in the preparation of medicaments for treating esophageal cancer. Background technique [0002] Ulinastatin is a broad-spectrum protease inhibitor, which belongs to human endogenous anti-inflammatory substances. It is mainly synthesized in the liver, metabolized by the kidneys and excreted in urine, and the low molecular weight components formed by its decomposition also have a strong inhibitory effect on hydrolytic enzymes. It has strong anti-inflammatory, immune regulation, microcirculation improvement, anti-shock, anti-ischemia and neuroprotective effects. In addition, studies have shown that ulinastatin has protective effects on the heart, liver, kidney, lung and other important organs of the human body. Chinese patent application 201410058044.X discloses the use of artesunate combined with ulinastatin in the treatment of pancreatitis. The...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/57A61K9/08A61K9/19A61K47/26A61P35/00
CPCA61K38/57A61K9/0019A61K9/08A61K9/19A61K47/26
Inventor 宋建东叶晓春孙明晖侯维静赵菁
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com