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Automated histological processing of biological samples and related technologies

A technology of sample and processing equipment, which is applied in the preparation of test samples, sampling, scientific instruments, etc., and can solve the problems of inability to achieve control of dyeing characteristics, slowness, etc.

Active Publication Date: 2020-01-03
VENTANA MEDICAL SYST INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of the apparatus described in the '326 patent and similar machines for this process is unacceptably slow
Moreover, these machines do not enable control over the dyeing properties

Method used

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  • Automated histological processing of biological samples and related technologies
  • Automated histological processing of biological samples and related technologies
  • Automated histological processing of biological samples and related technologies

Examples

Experimental program
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Embodiment Construction

[0119] It would be desirable to increase the consistency and controllability of certain attributes (eg, staining intensity) of histologically processed samples. Processing time (ie, the duration of a given histological treatment) and processing temperature (ie, the temperature at which a given histological treatment is performed) are two variables that affect most, if not all, of these attributes. Automated organizational systems constructed in accordance with at least some embodiments of the present technology include features that facilitate consistency and controllability of processing time and / or processing temperature. For example, at least some of these systems include a stainer with a treatment head capable of performing precisely controlled liquid dispensing and removal operations. These dyers can also have an internal environment that can be maintained at an elevated baseline temperature. The performance (eg, with respect to quality and versatility) of these and othe...

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Abstract

An automated system and method configured to perform processing operations on one or more slides on a slide-carrying biological sample. The systems and methods enable high sample throughput while also minimizing or limiting the possibility of slide cross-contamination. The automated system includes features that facilitate consistency and controllability of processing time and / or processing temperature.

Description

technical field [0001] The present technology generally relates to automated histological processing of biological samples (eg, tissue samples), such as systems, devices, methods and compositions that improve the quality, accuracy, efficiency, and / or otherwise of such processing. Background technique [0002] Biological samples can be analyzed using a variety of techniques. Examples of analytical techniques useful in this context include microscopic analysis, microarray analysis (eg, protein and nucleic acid microarray analysis), and mass spectrometry. Preparation of samples for these and other types of analysis typically involves contacting the sample with a series of processing liquids. Some of these processing fluids (e.g., staining reagents and counterstaining reagents) can add color and contrast or otherwise, alter the vision of invisible or hard-to-see sample components (e.g., at least some types of cells and intracellular structures) characteristic. Other processin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/31G01N35/00
CPCG01N35/00029G01N1/312G01N35/10G01N2035/00138
Inventor K.卡普斯H.格罗尔B.H.克拉姆M.梅特A.莫萨维D.奥康纳T.帕卢齐克B.兰达尔K.斯图姆佩C.谢G.沃德
Owner VENTANA MEDICAL SYST INC