Application of CAR-T cell carrying PD-L1 and CTLA-4 antibody genes in tumor immunology

A technology of CTLA-4, PD-L1

Inactive Publication Date: 2016-07-27
广东朗源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

The current popular way is to directly inject PD-L1 antibody and CTLA-4 antibody to enhance the function of tumor immune response, but the injection is expensive

Method used

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  • Application of CAR-T cell carrying PD-L1 and CTLA-4 antibody genes in tumor immunology

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Embodiment Construction

[0011] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0012] see figure 1 , in an embodiment of the present invention, an application of CAR-T cells carrying PD-L1 and CTLA-4 antibody genes in tumor immunity, where the CAR-T cells directly express PD-L1 antibodies and CTLA-4 antibodies.

[0013] T cells have good application potential in eliminating cancer cells, and CAR-T, chimeric antigen receptor T cells, is currently a relatively effective method for malignant tumors and is considered to be one of the most pr...

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Abstract

The invention discloses application of a CAR-T cell carrying PD-L1 and CTLA-4 antibody genes in tumor immunology. The CAR-T cell directly expresses a PD-L1 antibody and a CTLA-4 antibody. Due to the fact that the CAR-T cell directly expresses the PD-L1 antibody and the CTLA-4 antibody, a tumor immunoreaction is enhanced, the defects that exogenous injection of the PD-L1 antibody and the CTLA-4 antibody is inconvenient and expensive are overcome, the CAR-T cell expresses the PD-L1 antibody and the CTLA-4 antibody, and the problems of repeated injection and high price can be solved.

Description

technical field [0001] The present invention relates to the field of tumor immunity, in particular to the application of CAR-T cells carrying PD-L1 and CTLA-4 antibody genes in tumor immunity. Background technique [0002] Tumor immunity is a science that studies the relationship between tumor antigenicity, the body's immune function and tumor occurrence and development, the body's immune response to tumors and the mechanism of anti-tumor immunity, tumor immunodiagnosis, and immune prevention and treatment. It is assumed that tumor cells may have different antigenic components from normal tissues. By detecting this antigenic component or using this antigenic component to induce the body’s anti-tumor immune response, the purpose of diagnosis and treatment of tumors can be achieved, but no significant research has been achieved in this area. Progress. The current popular way is to directly inject PD-L1 antibody and CTLA-4 antibody to enhance the function of tumor immune respo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17A61P35/00
CPCA61K35/17
Inventor 辛炳川
Owner 广东朗源生物科技有限公司
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