Compound thrombus relieving soft capsule and preparation technology thereof

A preparation process and soft capsule technology, which can be used in capsule transportation, blood diseases, pharmaceutical formulations, etc. It can solve the problems of adverse effects on drug stability, long impregnation time, and large amount of solvent, so as to avoid quality impact and shorten extraction time. , good dissolution effect

Inactive Publication Date: 2016-07-27
广东广发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above Panax notoginseng has been impregnated twice, the first time is 4-6 days, the second time is 1-3 days, a total of 5-9 days, the impregnation takes a long time, the amount of solvent is large, and the efficiency is low; the three medicinal materials Astragalus and Salvia , Xuan heating and reflux twice, the first time is 2 to 8 hours, and the second time is 1 to 3 hours, a total of 3 to 11 hours, which takes a long time and has a certain adverse effect on the stability of the drug

Method used

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  • Compound thrombus relieving soft capsule and preparation technology thereof
  • Compound thrombus relieving soft capsule and preparation technology thereof
  • Compound thrombus relieving soft capsule and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A compound thrombosis soft capsule, which is composed of valid dried cream powder with soybean oil and beeswax; effective dried cream powder includes the following weight medicinal extraction: 3700 copies, 300 copies of astragalus, and Salva 100 100300 parts and Xuan ginseng; the weight ratio of valid dried paste and soybean oil is 3: 7, and the proportion of beeswax is 4%of soybean oil;The portion and water are made of 1.2 portion.

[0045] A preparation process of compound thrombus passing soft capsules, including the following process steps:

[0046] (1) Preparation of capsules content:

[0047] Preparation of A1 and Sanqi dried cream powder: By weight, smash Sanqi to 40 mesh pink, and seeps three times continuously at 30 ° C.Add 2 times 70 % ethanol to seep for 2 hours, and add 70 % ethanol for 1 hour for the third time.Get three -seven dried cream, spare;

[0048] B1, the preparation of the remaining medicinal materials dry paste: According to weight, add 65 % ethanol ...

Embodiment 2

[0066] The difference between this embodiment and Example 1 is that: a compound thrombosis soft capsule in this implementation is composed of effective dried cream powder with soybean oil and beeswax; effective dried cream powder includes the following weightsDetaisage of medicinal materials: 3700 copies, 200 copies of astragalus, 200 copies of Sands Sinusa, 200 copies of Xuan Ginseng; the weight ratio of valid dried cream and soybean oil is 3: 7, and the addition of beeswax is 4% of soybean oil.; The capsule is made of 0.95 copies, 0.3 copies of glycerin, and 0.9 parts of the megede.

[0067] A preparation process of compound thrombus passing soft capsules, including the following process steps:

[0068] (1) Preparation of capsules content:

[0069] Preparation of A1 and Sanqi Dry Cream powder: By the weight of the weight, smash Sanqi into 50 mesh pink, and seeps three times in a row of 25 ° C: 3 times the amount of 80 % ethanol for 3 hours, and join the second time.2 times 80 % ...

Embodiment 3

[0078] A compound thrombosis soft capsule, which is composed of effective dried cream powder with soybean oil and beeswax; effective dried cream powder includes the following weight medicinal extraction: 3700 copies, 300 copies of astragalus, Salviasis 140 140300 parts and Xuan ginseng; the weight ratio of valid dried paste and soybean oil is 5: 5, and the proportion of beeswax is 5%of soybean oil; the caps of the sac is 1.05 copies of gelatin at the weight of the weight, 0.4 glycerin 0.4The portion and water are made of 0.9 parts.

[0079] A preparation process of compound thrombus passing soft capsules, including the following process steps:

[0080] (1) Preparation of dry cream powder of medicinal materials:

[0081] Preparation of A1 and Sanqi dried cream powder: By the weight of the weight, smash the Sanqi into 60 mesh pink, add 70%ethanol of 3 times the weight of Sanqi powder, and continuously seep to high -efficiency liquid chromatography at 35 ° C to measure SanqiTotal sap...

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Abstract

The invention relates to the technical field of traditional Chinese medicinal pharmacy, and especially relates to a compound thrombus relieving soft capsule and a preparation technology thereof. The content of the soft capsule is composed of effective dry extract powder, soybean oil and beeswax; the effective dry extract powder comprises extracts obtained through extracting the following medicinal materials, by weight, 600-800 parts of panax notoginseng, 200-300 parts of Radix Astragali, 100-200 parts of Salvia miltiorrhiza and 200-300 parts of Radix Scrophulariae; a weight ratio of the effective dry extract powder to the soybean oil is 3-5:7-5, and the proportion of the beeswax is 4-6% of the proportion of the soybean oil; and the shell of the capsule is prepared from, by weight, 0.95-1.05 parts of gelatin, 0.3-0.5 parts of glycerin and 0.8-1.2 parts of water. The compound thrombus relieving soft capsule has the advantages of accurate content, good stability, good dissolution, fast absorption, small side effects, portability, small dosage, high bioavailability, rapid curative effect and good effect.

Description

Technical field [0001] The present invention involves the field of traditional Chinese medicine and pharmaceutical technology, especially a compound thrombus and a soft capsule and its preparation technology. Background technique [0002] Cardiovascular and cerebrovascular diseases and diabetes, tumors, etc. are the three major types of diseases that are currently threatened to human beings. Among them, cardiovascular and cerebrovascular diseases are the first of these three major diseases, known as the "number one killer" that threatens human health. [0003] According to the guidance of the theory of Chinese medicine, compound thrombosis capsules consisting of Sanqi, Astragalus, Danshen and Xuan Ginseng as prescriptions are drugs developed for cardiovascular and cerebrovascular diseases.Because cardiovascular and cerebrovascular diseases have the characteristics of urgency and fierceness, general hard containers and tablets cannot achieve the effect of rapid effects. Therefore,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K9/48A61P7/02A61P9/00A61J3/07
Inventor 夏羽李渡春钟耀清黄斌安天祥
Owner 广东广发制药有限公司
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