Biomarkers for the diagnosis and the response to treatment of pancreatic cancer

A technology for pancreatic cancer and pancreatic ductal adenocarcinoma, which is applied in the fields of molecular biology and medicine, and can solve problems such as increasing the survival of DACP patients

Inactive Publication Date: 2016-08-03
UNIV DE GRANADA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, no improvement has emerged to increase the survival of DACP patients (Hidalgo, 2010. Pancreaticcancer. N. Engl. J. Med. 362, 1605-1617; Costello et al., 2012. Nat. Rev. Gastroenterol Hepatol. 9, 435-444.)

Method used

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  • Biomarkers for the diagnosis and the response to treatment of pancreatic cancer
  • Biomarkers for the diagnosis and the response to treatment of pancreatic cancer
  • Biomarkers for the diagnosis and the response to treatment of pancreatic cancer

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Embodiment Construction

[0054] The word "comprise" and its variants in the description and claims are not intended to exclude other technical features, additives, components or steps. Those skilled in the art can understand other purposes, advantages and features of the present invention partly by reading the specification and partly by implementing the present invention.

[0055] concept definition

[0056] An "isolated biological sample" includes, among other things, cells, tissues and / or biological fluids of the body obtained by any method known to those skilled in the art.

[0057] The term "individual" referred to in this specification relates to animals, preferably mammals, more preferably humans. The term "individual" is not intended to be limiting and in any respect may be an individual of any age, sex and physical condition.

[0058] The expression levels of the genes will result in a specific gene expression profile. The term "expression level", also called "gene product amount" or "ex...

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Abstract

The invention relates to biomarkers, a method and a kit for early diagnosis of pancreatic cancer, in particular of pancreatic ductal adenocarcinoma (PDAC); and to biomarkers, a method and a kit or device for predicting or prognosticating an individual's response to combined treatment with a nucleoside analogue (preferably gemcitabine) and a growth factor receptor (preferably erlotinib) in patients with pancreatic ductal adenocarcinoma.

Description

technical field [0001] The invention belongs to the fields of molecular biology and medicine. In particular, the present invention relates to methods for obtaining useful data for the early diagnosis of pancreatic ductal adenocarcinoma. Early diagnosis was made by analyzing the biomarkers FGF10, CXCL11, OSM, GPNMB and SCF. The present invention also relates to methods for obtaining useful data for predicting or prognosing the response of patients with pancreatic ductal adenocarcinoma to the combination therapy of a nucleoside analogue (gemcitabine) and a growth factor receptor (erlotinib). Prognosis was performed by analyzing serum biomarkers CD80, EG-VEGF, IL-29, NRG1-β1 and PD-ECGF. Background technique [0002] pancreatic ductal adenocarcinoma [0003] Although pancreatic ductal adenocarcinoma (DACP) accounts for only 2.68% of all cancers, it has the highest mortality among all types of cancers. Last year (2012) there were 44,000 new cases of this cancer, of which 37...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/57438G01N2800/60C07K16/22C07K16/24C07K16/243C07K16/248C07K16/28G01N2333/47G01N2333/50G01N2333/52G01N2333/522G01N2333/5412
Inventor 卡罗利纳·托雷斯·佩拉莱斯索尼亚·佩拉莱斯·罗梅罗胡安·雷蒙·德尔加多·佩雷斯安东尼奥·伊里戈延·玛蒂娜玛丽亚·何塞·亚历杭德罗·佩雷斯何塞·伊格莱西亚斯·戈麦斯罗杰利奥·帕洛米诺·莫拉莱斯奥克塔维奥·卡巴·佩雷斯何塞·卡洛斯·普拉杜斯·萨拉萨尔安东尼娅·阿拉内加·吉梅内斯安娜·利纳雷斯·吉尔
Owner UNIV DE GRANADA
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