Oxidation-resistant astaxanthin mask and preparation method thereof
An astaxanthin and antioxidant technology, applied in cosmetic preparations, cosmetics, pharmaceutical formulations, etc., can solve problems such as rough skin, dullness and dullness, slow down skin aging, promote cell metabolism, and repair damaged epidermis cells. Effect
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[0018] The embodiment of the present invention provides an astaxanthin anti-oxidation facial mask, the ingredients of which are calculated in parts by weight: 5-15 parts of glycerin, 5-10 parts of honey, 5-15 parts of aloe extract, 2-10 parts of lemon oil 5-10 parts of arbutin, 2-5 parts of astaxanthin, 4-10 parts of hydroxypropyl-β-cyclodextrin, 2-5 parts of ethanol, 0.01-0.1 parts of methylparaben, 30 parts of distilled water ~45 parts The present invention also provides a kind of preparation method of astaxanthin anti-oxidation mask, comprising the following steps:
[0019] Step S101, dissolving astaxanthin and hydroxypropyl-β-cyclodextrin in dichloromethane and methanol respectively, and then fully mixing the above-mentioned substances under a nitrogen atmosphere.
[0020] Step S102, the above mixture is ultrasonically treated and vacuum-dried to prepare an astaxanthin / hydroxypropyl-β-cyclodextrin inclusion compound, and then redispersed in distilled water, filtered, and f...
Embodiment 1
[0025] Step 1: Accurately weigh 3mg of astaxanthin and dissolve in 3mL of dichloromethane; accurately weigh 6mg of hydroxypropyl-β-cyclodextrin and dissolve in 12mL of methanol. The materials were mixed well under nitrogen atmosphere.
[0026] Step 2: The mixture obtained in step 1 was sonicated at 500W, the sonication interval was 2s, the sonication time was 3s, and the total sonication time was 5min, to obtain astaxanthin / hydroxypropyl-β-cyclodextrin inclusion compound. Then placed in a vacuum oven at 25°C for 24h. The dried clathrate powder was redispersed in 5 mL of distilled water, stirred evenly to dissolve, and then filtered to remove impurities. Finally, the filtered solution was placed in a freeze dryer for 48 hours to obtain a pure astaxanthin / hydroxypropyl-β-cyclodextrin inclusion compound.
[0027] Step 3: Accurately weigh 35mg of distilled water into a beaker, then add 15mg of glycerin, 9mg of honey, 14mg of aloe extract, 8mg of lemon oil, 5mg of arbutin, 3mg of...
Embodiment 2
[0031] Step 1: Accurately weigh 4 mg of astaxanthin, dissolve in 4 mL of dichloromethane; accurately weigh 8 mg of hydroxypropyl-β-cyclodextrin, and dissolve in 16 mL of methanol. The materials were mixed well under nitrogen atmosphere.
[0032] Step 2: The mixture obtained in step 1 was sonicated at 500W, the sonication interval was 2s, the sonication time was 3s, and the total sonication time was 5min, to obtain astaxanthin / hydroxypropyl-β-cyclodextrin inclusion compound. Then place it in a vacuum oven at 25°C for 24 hours, redisperse the dried clathrate powder in 5 mL of distilled water, stir evenly to dissolve, and then filter to remove impurities. Finally, the filtered solution was placed in a freeze dryer for 48 hours to obtain a pure astaxanthin / hydroxypropyl-β-cyclodextrin inclusion compound.
[0033] Step 3: Accurately weigh 40mg of distilled water into a beaker, then add 10mg of glycerin, 8mg of honey, 10mg of aloe extract, 5mg of lemon oil, 5mg of arbutin, 5mg of e...
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