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Periplaneta americana extract and preparation process thereof

A kind of American cockroach, the technology of preparation process, applied in the directions of drug combination, medical raw materials from arthropods, digestive system, etc., can solve the problems of patient's resistance, low content of active ingredients, dark color of extract, etc., to achieve liquid color and luster The effect of shallow, good quality and simple process operation

Inactive Publication Date: 2016-08-24
四川好医生盘西药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the content of active ingredients such as small molecular peptides and amino acids in the Periplaneta americana extract extracted by the existing Periplaneta americana extract is low, and the obtained extract has a deep color and a strong fishy smell, which makes some patients feel uncomfortable during use. Resistance, and even nausea, vomiting and other gastrointestinal discomfort, resulting in the inability to continue treatment and delay the treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Adding 8 times the volume fraction of medicinal material dry weight in the weighed 10kg American cockroach body is after 8 hours of ethanol cold soaking of 75%, carry out the first reflux, and the reflux time is 2.5 hours; The 75% ethanol of 6 times of the amount of the dry weight of the medicinal material was refluxed for the second time, and the reflux time was 2 hours; the 75% ethanol of the 6 times of the amount of the original medicinal material dry weight was continued to be added in the medicinal residues to reflux for the third time, and the reflux time was 2 hours. Hours; the reflux temperature is controlled at 70-80°C, and the extracts obtained by reflux three times are combined, filtered through a 100-mesh screen to obtain the ethanol extract, which is slowly non-foaming and added to the double-effect concentrator for concentration, and the double-effect concentrator sets the conditions The first-effect vacuum degree is -0.02~-0.04Mpa, the temperature is 65~70...

Embodiment 2

[0031] Adding 8 times the volume fraction of medicinal material dry weight in the weighed 10kg American cockroach body is after 8 hours of ethanol cold soaking of 75%, carry out the first reflux, and the reflux time is 2.5 hours; The 75% ethanol of 4 times the dry weight of the medicinal material is refluxed for the second time, and the reflux time is 2 hours; the reflux temperature is controlled at 70-80°C, the extract obtained by the second reflux is combined, and the 100-mesh sieve is filtered to obtain the ethanol extraction. The liquid is slowly added into the double-effect concentrator for concentration without foaming. The setting conditions of the double-effect concentrator are that the vacuum degree of the first effect is -0.02~-0.04Mpa, and the temperature is 65~70°C; the vacuum degree of the second effect is -0.06~ -0.04Mpa, the temperature is 60-65°C, concentrate to a thick paste with a relative density of 1.08, add the obtained thick paste to purified water that ha...

Embodiment 3

[0033] Adding the volume fraction of 8 times the amount of medicinal material dry weight in the weighed 10kg American cockroach body is after 8 hours of ethanol cold soaking of 75%, carries out the first reflux, and the reflux time is 2.5 hours, and then the medicinal residues are carried out Reflux extraction 3 times, add 75% ethanol of 4 times the dry weight of the original medicinal material to the dregs each time for reflux extraction, the reflux time is 2 hours, the reflux temperature is controlled at 70-80°C, and the extracts obtained by reflux four times are combined , filter the 100-mesh sieve to obtain the ethanol extract slowly without foaming, and then add it to the double-effect concentrator for concentration. ℃; the second-effect vacuum degree is -0.06~-0.04Mpa, the temperature is 60~65℃, concentrated to a thick paste with a relative density of 1.15, and the obtained thick paste is added to purified water that has been heated to 80℃, and the purified water The amo...

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PUM

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Abstract

The invention provides a periplaneta americana extract and a preparation process thereof. The preparation process comprises the following steps: soaking periplaneta americana bodies in 60-79% ethanol, conducting reflux extraction, concentration and degreasing. The preparation process disclosed by the invention is simple to operate and is capable of saving cost and energy. The periplaneta americana extract prepared by the method disclosed by the invention has the following advantages: the periplaneta americana extract is high in content of active ingredients, wherein the content of free amino acid can achieve 3.54g / 100g of crude drug or above; and the periplaneta americana extract is obvious in therapeutic effect on UC, free from fishy smell and light in color.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an extract of Periplaneta americana and a preparation process thereof. Background technique [0002] Peptic ulcers mainly refer to chronic ulcers that occur in the stomach and duodenum, but can also occur in the lower esophagus, around the gastrojejunostomy, and in MECKEL's diverticulum containing ectopic gastric mucosa. A large number of studies have fully proved that Helicobacter pylori infection is the main cause of peptic ulcer. Its clinical manifestation is epigastric pain, often presents dull pain, dull pain, distending pain, burning pain. The pain of gastric ulcer usually occurs within 1 hour after a meal, and gradually relieves after 1 to 2 hours, and the above rhythm reappears until the next meal. Some patients may be asymptomatic, or have complications such as bleeding and perforation as the first symptom. Ulcer disease is a chronic common disease, and it ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P1/00
Inventor 陈光健
Owner 四川好医生盘西药业有限责任公司
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