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Application of industrial cannabinoid in preparing drugs for treating gouty arthritis

A technology of gouty arthritis and industrial hemp, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of myelosuppression, large side effects, and prone to gastrointestinal symptoms, etc., to achieve symptom relief, rich sources, and good Effects of Medicinal Foreground

Inactive Publication Date: 2016-10-12
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, colchicine, a specific drug for the clinical treatment of acute gouty arthritis, has relatively large side effects, and is prone to adverse reactions such as gastrointestinal symptoms and bone marrow suppression. Therefore, it is urgent to develop a drug with specific effects and relatively small side effects

Method used

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  • Application of industrial cannabinoid in preparing drugs for treating gouty arthritis
  • Application of industrial cannabinoid in preparing drugs for treating gouty arthritis
  • Application of industrial cannabinoid in preparing drugs for treating gouty arthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0025] The flowers, leaves and hemp bran of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Mix flowers, leaves, and hemp bran in a mass ratio of 1:3:2, then dry, remove impurities, and crush to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned crushed industrial hemp raw materials into supercritical carbon dioxide In the extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure is 25-35Mpa, the carbon dioxide flow rate is 40kg / h, and the extract is collected at the outlet of the separation kettle; % (V / V) ethanol for elution, the number of elutions is 1 to 3 times; the eluate is collected, concentrated under reduced pressure, dried in vacuo, and pulverized to obtain the cannabinoid of industrial hemp.

Embodiment 2

[0027] Repeat embodiment 1, following difference is arranged: get the flower of industrial hemp, leaf, the mixture of hemp bran 1:1:1 mass ratio as the extraction raw material of industrial hemp cannabinoid.

Embodiment 3

[0029] Repeat embodiment 1, have the following difference: get the flower of industrial hemp, leaf, the mixture of hemp bran 3:2:1 mass ratio as the extraction raw material of industrial hemp cannabinoid.

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Abstract

The invention discloses application of industrial cannabinoid in preparing drugs for treating gouty arthritis. The inventor finds that the cannabinoid prepared through industrial hemp has the effect of significantly reducing creatinine and uric acid in serum of mice with hyperuricemia and prevents and treats hyperuricemia for the first time; meanwhile, the cannabinoid can regulate cell factors of bodies, effectively resist inflammation and relieve symptoms of the gouty arthritis and has obvious treating and preventing effects on the gouty arthritis. The invention further provides a pharmaceutical preparation of the industrial cannabinoid for treating the gouty arthritis and corresponding pharmaceutical dosage forms of the pharmaceutical preparation. The industrial cannabinoid can be prepared into clinically applied drugs of different dosage forms through a conventional preparation method, and use is convenient.

Description

technical field [0001] The invention relates to the new application of cannabis in medicine, in particular to the application of a kind of industrial hemp cannabinoid in the preparation of medicine for treating gouty arthritis. Background technique [0002] Gouty arthritis is a class of diseases caused by purine metabolism disorders in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion is decreased, which can cau...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P19/02A61P19/06
CPCA61K36/60A61K2236/333A61K2236/37A61K2236/39A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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