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Medicine composition with cough relieving effect, and preparation method and application thereof

A composition and antitussive technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of low content of active ingredients, inconvenient taking, difficult quality control, etc., to achieve easy preparation, drug Simple composition, enhanced antitussive effect

Active Publication Date: 2016-10-26
贵州盛世泰合医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of Chinese medicinal materials in these compound prescriptions, but the content of active ingredients is low, and it is inconvenient to take and difficult to control the quality.

Method used

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  • Medicine composition with cough relieving effect, and preparation method and application thereof
  • Medicine composition with cough relieving effect, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of centristine

[0030] The preparation method of centristine used in the examples is prepared with reference to the document "Journal of Natural Products 2006, 69, 749-754".

[0031] Take 1 kg of Baibu produced in Yudu, Jiangxi, and reflux it with 95% ethanol (5 L) for 3 times, each time for 2 hours. The extracts were combined, and the solvent was recovered by a rotary evaporator to obtain the total extract. The total extract was suspended in water (600 mL), extracted 3 times with hexane and ethyl acetate successively (200 mL each time), combined the ethyl acetate extracts, and recovered the solvent with a rotary evaporator to obtain the ethyl acetate extraction fraction ( 26g). Pass the ethyl acetate extraction part through a silica gel column, elute with hexane-ethyl acetate 20:1, 10:1, 5:1, 2:1 (each 2000mL), concentrate with a rotary evaporator 5:1 and elute part to obtain centristine (2.6g).

Embodiment 2

[0032] Example 2: Preparation of the composition of centristine-mogroside IV

[0033] Take tribucinine (3.96g, 0.01mmol) and mogroside IV (purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.) (11.24g, 0.01mmol), and mix them with a vortex shaker for 3 minutes to obtain 15.20 g of the combination of neobine and mogroside IV (molar ratio 1:1).

Embodiment 3

[0034] Example 3: Preparation of the composition of centristine-mogroside IV

[0035] Take centristine (3.96g, 0.01mmol) and mogroside IV (purchased by Shanghai Aladdin Biochemical Technology Co., Ltd.) (22.48g, 0.02mmol), and mix it with a vortex shaker for 5 minutes to obtain centristine Alkaline and mogroside IV composition 26.44g (molar ratio 1:2).

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Abstract

The invention belongs to the field of a medicine preparation, and discloses a medicine composition with a cough relieving effect, and a preparation method and application thereof. The medicine composition is prepared from stemoninine and mogroside, wherein the mogroside can be at least one kind from mogroside IV and mogroside V. The stemoninine and the mogroside are used in a combined way, so that the functions of relieving cough and reducing phlegm are realized; the cough relieving effect is enhanced; the medicine composition is simple; and the preparation is easy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition for antitussive and its preparation method and application. Background technique [0002] Cough is a non-specific symptom that is common in people's daily life. Although coughing is not fatal, it will bring us a lot of inconvenience, and severe and frequent coughing can make patients feel restless and cause complications, and also seriously affect people's sleep, leading to aggravation of the condition. [0003] The antitussive drug market is huge. Epidemiological data from the over-the-counter (OTC) market shows that the UK spends hundreds of millions of pounds on cough treatment each year, while the United States has billions of dollars. It can be seen that people have a huge demand for cough treatment and Pay attention to. Currently, most of the clinical drugs for treating cough are central antitussives, such as codeine, dextromethorpha...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P11/14A61K31/55
CPCA61K31/55A61K31/704A61K2300/00
Inventor 江仁望易敏田海妍朱自荣吴旖黄超刘灿群
Owner 贵州盛世泰合医药科技有限公司
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