Method for extracting iphigenia indica colchicine in auxiliary manner by adopting micro-cutting assisting interaction technology

A technology of micro-cutting assisted interaction and assisted extraction, which is applied in the fields of organic chemistry, carboxylic acid amide separation/purification, etc., can solve the constraints on the research, development and application of effective active ingredients of plants, cannot be applied to industrial production practices, and the water solubility of active ingredients is poor To achieve the effect of accelerating the speed of osmotic dissolution and diffusion, improving the rate of cell wall breaking and shortening the extraction time

Inactive Publication Date: 2016-10-26
唐翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, many domestic and foreign scholars have continuously explored and optimized the extraction process of plant effective active ingredients, and some new extraction and separation technologies have emerged, such as microwave, ultrasonic, ultrafine pulverization, supercritical, etc. Although these new Technology has made significant progress compared with traditional technology, but the problems of poor water solubility and low utilization of active ingredients have not been fundamentally solved, and some technologies are limited to laboratory research due to special equipment, and cannot be applied to industrial production practice
It can be seen that the imperfection of extraction technology has always been a key issue restricting the further research, development and application of effective plant active ingredients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The method for assisting the extraction of narcissin from Arrowhead mushroom by using the micro-cutting-aided interaction technique comprises the following steps:

[0019] (1) Take Arrowhead mushrooms and wash them, then dry them under vacuum conditions, control the water content of Arrowhead mushrooms to be below 5% after drying, then crush the dried Arrowhead mushrooms, pass through a 30-mesh sieve, and get Arrowhead mushroom powder ;

[0020] (2) Put Arrowhead mushroom powder and sodium carbonate into a planetary mill or a vibrating mill for 20 minutes in a weight ratio of 95:5 to obtain a mixed micropowder;

[0021] (3) Put the mixed micropowder and 60% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 12ml, and perform ultrasonic countercurrent extraction for 25 minutes under the action of ultrasonic waves with a frequency of 60KHz, a power of 400w, and a temperature of 40°C , filte...

Embodiment 2

[0025] The method for assisting the extraction of narcissin from Arrowhead mushroom by using the micro-cutting-aided interaction technique comprises the following steps:

[0026] (1) Take Arrowhead mushrooms and wash them, then dry them under vacuum conditions, control the water content of Arrowhead mushrooms to be below 5% after drying, then crush the dried Arrowhead mushrooms, pass through a 40-mesh sieve, and get Arrowhead mushroom powder ;

[0027] (2) Put Arrowhead mushroom powder and sodium carbonate into a planetary mill or a vibrating mill for 10 minutes in a weight ratio of 96:4 to obtain a mixed micropowder;

[0028] (3) Put the mixed micropowder and 65% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 15ml, and perform ultrasonic countercurrent extraction for 15 minutes under the action of ultrasonic waves with a frequency of 80KHz, a power of 300w, and a temperature of 50°C , filte...

Embodiment 3

[0032] The method for assisting the extraction of narcissin from Arrowhead mushroom by using the micro-cutting-aided interaction technique comprises the following steps:

[0033] (1) Take Arrowhead mushrooms and wash them, then dry them under vacuum conditions, control the water content of Arrowhead mushrooms to be below 5% after drying, then crush the dried Arrowhead mushrooms, pass through a 50-mesh sieve, and get Arrowhead mushroom powder ;

[0034] (2) Put Arrowhead mushroom powder and sodium carbonate in a planetary mill or vibratory mill for 30 minutes in a weight ratio of 98:2 to obtain a mixed micropowder;

[0035] (3) Put the mixed micropowder and 50% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 10ml, and perform ultrasonic countercurrent extraction for 10 minutes under the action of ultrasonic waves with a frequency of 30KHz, a power of 450w, and a temperature of 60°C , filter th...

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PUM

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Abstract

The invention discloses a method for extracting iphigenia indica colchicine in an auxiliary manner by adopting a micro-cutting assisting interaction technology. The method comprises the following steps: firstly, cleaning iphigenia indica, and drying and crushing to prepare iphigenia indica powder; then mixing and grinding the iphigenia indica powder and sodium carbonate to prepare mixed micro powder; then putting the mixed micro powder into a single-stage continuous countercurrent ultrasonic extraction machine to carry out ethanol extraction; finally, conducting reduced pressure distillation and drying on an extracted filtrate, so as to obtain iphigenia indica colchicine. Compared with the prior art, according to the method for extracting iphigenia indica colchicine in an auxiliary manner by adopting the micro-cutting assisting interaction technology, the solubility of colchicine in an ethanol solution can be effectively improved under the ultrafine powder stage, and the precipitation rate of colchicine can be further increased; in the process of colchicine ethanol extraction, under the action of ultrasonic waves, the continuous countercurrent ultrasonic extraction technology is adopted in an auxiliary manner, the penetration-dissolution and diffusion rate in the colchicine extraction process can be accelerated, the extraction time can be shortened, the solvent use amount can be reduced, and the method for extracting colchicine is efficient and low in consumption.

Description

technical field [0001] The invention belongs to the technical field of extracting effective components of plants, and in particular relates to a method for assisting the extraction of narcissin from Arrowhead mushroom by using a micro-cutting-aided interaction technology. Background technique [0002] Natural plants are increasingly favored by people because of their rich resources, less toxic and side effects, no drug resistance, and no harmful residues. The ingredients contained in natural plants are very complex, which can be divided into active ingredients, ineffective ingredients and toxic ingredients. Active ingredients include terpenoids, glycosides, organic acids and trace elements. There are many extraction methods for effective active ingredients of natural plants, and the traditional extraction methods mainly include decoction, dipping, and reflux extraction. The decoction method is convenient and easy, but there are many impurities in the decoction liquid, whic...

Claims

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Application Information

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IPC IPC(8): C07C231/24C07C233/32
CPCC07C231/24C07C233/32
Inventor唐翔
Owner唐翔