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Microspheres for coding and decoding and coding and decoding method and decoding system thereof

A coding and decoding method and microsphere technology, applied in the field of biological detection, can solve problems such as coding accuracy and stability, and limitation of anti-interference ability, and achieve the effects of improving coding potential, good application prospects, and reducing costs

Inactive Publication Date: 2016-10-26
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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Problems solved by technology

In this scheme, due to the limitation of the characteristics of fluorescence itself, the accuracy, stability and anti-interference ability of the encoding are limited to a certain extent.

Method used

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  • Microspheres for coding and decoding and coding and decoding method and decoding system thereof
  • Microspheres for coding and decoding and coding and decoding method and decoding system thereof
  • Microspheres for coding and decoding and coding and decoding method and decoding system thereof

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Embodiment Construction

[0026] The present invention will be described in further detail below in combination with specific embodiments and with reference to the accompanying drawings.

[0027] The idea of ​​the present invention is to conduct in-depth research on the existing microsphere coding scheme. The fluorescent coding technology is based on the fluorescence emission spectrum, so there are many limitations: (1) Whether it is a fluorescent dye microsphere or a quantum dot microsphere, it is affected by Limited to the luminescence principle of fluorescence, the spectral peak width of the emitted light is wide, which easily leads to signal overlap in multi-component detection, which directly affects the encoding potential of the chip; (2) the encoding and decoding of fluorescence depends on the waveform of the spectrum, This requires the same kind of microspheres to have the same fluorescence intensity during the preparation process, and different types of microspheres must have sufficient disting...

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Abstract

The invention discloses microspheres for coding and decoding and a coding and decoding method and decoding system thereof. The coding and decoding method comprises the steps of S1, combining various nanometer materials containing metallic elements into microspheres to form various microspheres; S2, conducting laser inducing breakdown on one microsphere to be tested by means of pulse laser with pulse width at nanosecond scale and single pulse energy larger than 100 mJ; S3, receiving the plasma radiation spectrum generated by the microsphere to be tested after the microsphere is subjected to induced excitation; S4, conducting spectrum peak traversal in the plasma radiation spectrum, conducting comparison with standard spectrum peak data of a standard atomic spectrum, determining a data matched reference element as the metallic element in the nanometer material in the microsphere, and determining the microsphere to be tested as the microsphere containing the corresponding metallic element. Coding and decoding accuracy is high, and stability is high.

Description

【Technical field】 [0001] The invention relates to the technical field of biological detection, in particular to a microsphere used for encoding and decoding, an encoding and decoding method, and a decoding system. 【Background technique】 [0002] Biochip (biochip) technology is a high-throughput biomolecular detection technology that integrates microelectronics, life science, computer science and photoelectrochemistry, and is a major revolution in the field of life science. The traditional form of biochip technology is also called microarray (microarray) technology. Its principle is to integrate biomolecules (DNA, RNA, polypeptide, protein, etc.) of known sequence on a solid surface to form a probe array. The detected biomolecules are hybridized with the above-mentioned probe array, and the detection of biomolecules is achieved by detecting the hybridization probes at the corresponding positions. Traditional biochip hybridization belongs to solid-liquid phase hybridization, ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/71
CPCG01N21/718
Inventor 何永红何清华孙树清
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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