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Acotiamide hydrochloride dispersible tablets and preparation method thereof

A technology of acotiamide hydrochloride and dispersible tablets, which is applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve problems such as aggravation, achieve high bioavailability, and improve drug intake Effects of compliance and less intestinal residue

Inactive Publication Date: 2016-11-09
FOSHAN TENGRUI MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 2. Upper abdominal distension mostly occur

Method used

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  • Acotiamide hydrochloride dispersible tablets and preparation method thereof
  • Acotiamide hydrochloride dispersible tablets and preparation method thereof
  • Acotiamide hydrochloride dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0023] prescription:

[0024]

[0025] Preparation:

[0026] (1) Mix acotiamide hydrochloride powder (200 mesh) and sucrose powder (150 mesh) in equal increments to obtain mixture A;

[0027] (2) Pass the remaining auxiliary materials through a 200-mesh sieve, and mix them uniformly in equal increments to obtain mixture B;

[0028] (3) Mix mixture A and mixture B uniformly according to the method of equal increase, and then directly compress into tablets.

Embodiment 2

[0030] prescription:

[0031]

[0032] Preparation:

[0033] (1) Mix acotiamide hydrochloride powder (200 mesh) and lactose powder (150 mesh) in equal increments to obtain mixture A;

[0034] (2) Pass the remaining auxiliary materials through a 200-mesh sieve, and mix them uniformly in equal increments to obtain mixture B;

[0035] (3) Mix mixture A and mixture B uniformly according to the method of equal increase, and then directly compress into tablets.

Embodiment 3

[0037] prescription:

[0038]

[0039] Preparation:

[0040] (1) Mix acotiamide hydrochloride powder (200 mesh) and lactose powder (150 mesh) in equal increments to obtain mixture A;

[0041] (2) Pass the remaining auxiliary materials through a 200-mesh sieve, and mix them uniformly in equal increments to obtain mixture B;

[0042] (3) Mix mixture A and mixture B uniformly according to the method of equal increase, and then directly compress into tablets.

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PUM

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Abstract

The invention discloses acotiamide hydrochloride dispersible tablets, used for treating idiopathic pulmonary fibrosis (IPF). The acotiamide hydrochloride dispersible tablets are prepared from acotiamide hydrochloride, with the addition of adjuvant materials. The acotiamide hydrochloride dispersible tablets are rapid in disintegration and absorption, high in bioavailability, convenient to take, low in content of intestinal residues, light in side effects, sweet in taste and fragrant; and especially, the dispersible tablets are easy to improve the medication compliance of patients and are capable of improving the taste of the preparation (the dispersible tablets); and a phenomenon of sticking is avoided in a tabletting process, which is conducive to the implementation of industrial production.

Description

technical field [0001] The invention relates to a new dosage form of acotiamide hydrochloride, in particular to acotiamide hydrochloride dispersible tablets and a preparation method thereof. Background technique [0002] Functional dyspepsia (FD) refers to epigastric symptoms such as epigastric pain, epigastric distension, early satiety, belching, loss of appetite, nausea, and vomiting that accumulate for more than 12 weeks within a year, and various objective examinations fail to detect organic diseases . It is a frequently-occurring and common disease worldwide. According to the statistics of hospital patients in western countries, FD patients account for 2%-3% of the total number of internal medicine patients, accounting for about 20%-40% of digestive outpatient clinics. Patients complain of more symptoms and fewer objective indicators, and are generally diagnosed according to the 1999 Rome II criteria. Its pathogenesis is still unclear. It is generally believed that up...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/426A61K47/20A61K47/34A61K47/22A61K47/26A61P1/14
CPCA61K9/0056A61K9/2013A61K9/2018A61K9/2031A61K31/426A61K47/10A61K47/20A61K47/22A61K47/26
Inventor 王雪峰候建红
Owner FOSHAN TENGRUI MEDICINE TECH CO LTD