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Traditional Chinese medicine preparation for treating renal toxicity after radiotherapy and chemotherapy and preparation method and application thereof

A traditional Chinese medicine preparation and nephrotoxic technology, applied in the field of medicine, can solve the problems of dose limitation, toxicity, and kidney production, and achieve the effects of reducing blood creatinine and urea nitrogen levels, less toxic side effects, and a short course of treatment

Inactive Publication Date: 2016-11-09
JINZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term administration of anti-tumor drugs in cancer patients will cause nephrotoxicity, and the choice of dosage is limited in the course of clinical application

Method used

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  • Traditional Chinese medicine preparation for treating renal toxicity after radiotherapy and chemotherapy and preparation method and application thereof
  • Traditional Chinese medicine preparation for treating renal toxicity after radiotherapy and chemotherapy and preparation method and application thereof
  • Traditional Chinese medicine preparation for treating renal toxicity after radiotherapy and chemotherapy and preparation method and application thereof

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Effect test

Embodiment 1

[0023] In the embodiment of the present invention, a traditional Chinese medicine preparation for the treatment of nephrotoxicity after radiotherapy and chemotherapy is composed of the following raw materials in parts by weight: 20 parts of hornbeam, 1 part of ginseng, 15 parts of Yahunu, and Lifei powder 10 parts, 8 parts of lily.

[0024] Grind bamboo joints and lilies separately, pass through a 120-mesh sieve, mix, add hydrogen peroxide solution 7 times the mass of the two, heat and stir at 48°C for 45 minutes, and then heat and stir at 60°C for 40 minutes to obtain the pretreated material , wherein the mass content of hydrogen peroxide in the hydrogen peroxide solution is 25%, and the solvent is water. Grind Lifei Powder, pass through an 80-mesh sieve, add deionized water 6 times its mass, decoct with high heat for 0.8h, and filter to obtain filtrate A. Crush the hornbeam and Yahunu, pass through an 80-mesh sieve, add deionized water 8 times the mass of the two, decoct wi...

Embodiment 2

[0026] In the embodiment of the present invention, a traditional Chinese medicine preparation for treating nephrotoxicity after radiotherapy and chemotherapy is composed of the following raw materials in parts by weight: 30 parts of Carina multimai, 5 parts of Bamboo Ginseng, 23 parts of Yahunu, and Lifei Powder 18 parts, 16 parts of lily.

[0027] Grind bamboo joints and lilies separately, pass through a 120-mesh sieve, mix, add hydrogen peroxide solution 7 times the mass of the two, heat and stir at 50°C for 50 minutes, and then heat and stir at 62°C for 45 minutes to obtain the pretreated material , wherein the mass content of hydrogen peroxide in the hydrogen peroxide solution is 30%, and the solvent is water. Grind Lifei Powder, pass through an 80-mesh sieve, add deionized water 6 times its mass, decoct with high heat for 1 hour, filter to obtain filtrate A. Crush the hornbeam and Yahunu, pass through an 80-mesh sieve, add deionized water 8 times the mass of the two, dec...

Embodiment 3

[0029] In the embodiment of the present invention, a traditional Chinese medicine preparation for the treatment of nephrotoxicity after radiotherapy and chemotherapy is composed of the following raw materials in parts by weight: 22 parts of hornbeam, 2 parts of bamboo ginseng, 17 parts of Yahunu, and Lifei powder 12 parts, 10 parts of lily.

[0030] Grind bamboo joints and lilies separately, pass through a 120-mesh sieve, mix, add hydrogen peroxide solution 7 times the mass of the two, heat and stir at 49°C for 48 minutes, and then heat and stir at 61°C for 42 minutes to obtain the pretreated material , wherein the mass content of hydrogen peroxide in the hydrogen peroxide solution is 28%, and the solvent is water. Grind Lifei Powder, pass through an 80-mesh sieve, add deionized water 6 times its mass, decoct with high heat for 0.9h, and filter to obtain filtrate A. Crush the hornbeam and Yahunu, pass through an 80-mesh sieve, add deionized water 8 times the mass of the two, ...

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating renal toxicity after radiotherapy and chemotherapy and a preparation method and application of the traditional Chinese medicine preparation for treating the renal toxicity after the radiotherapy and chemotherapy. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 20 to 30 parts of Carpinus polyneura, 1 to 5 parts of panax japonicus, 15 to 23 parts of common cissampelos herb, 10 to 18 parts of climbing oldenlandia, and 8 to 16 parts of lily. The panax japonicus and lily are respectively ground, sieved and mixed, and then added with a hydrogen peroxide aqueous solution to be heated to obtain a pretreatment material, the climbing oldenlandia is crushed and sieved, and added with deionized water to be decocted by strong fire, and filtered to obtain a filtrate A; the Carpinus polyneura and common cissampelos herb are crushed and sieved, and added with deionized water to be decocted by mild fire and filtered to obtain a filtrate B; the filtrate A is placed in the pretreatment material to be heated, and then the filtrate B is added to be heated, stirred and filtered to obtain the traditional Chinese medicine preparation. The traditional Chinese medicine preparation disclosed by the invention has a very good effect on renal toxicity caused by the radiotherapy and chemotherapy, small toxic and side effects, a short course of treatment and an obvious curative effect, can reduce toxic and side effects which occur in the treatment process possibly, and further can obviously improve the immunity of a cancer patient with the radiotherapy and chemotherapy.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine preparation for treating nephrotoxicity after radiotherapy and chemotherapy, a preparation method and application thereof. Background technique [0002] Conventional methods used to treat tumor diseases have certain toxic effects on many organs, especially kidney toxicity, which has attracted more and more attention. Studies have shown that in the radiation treatment of tumor diseases, the radiation dose is 1000-2000 rads, and the kidneys will not produce persistent pathological abnormalities within 2-3 weeks; when the dose is 2300-2500 rads, it will be visible after 4-5 weeks Histopathological changes in the early stage of the kidney are mostly manifested as proliferation of glomerular endothelial cells and hyalinoid deposition in the inner and middle layers of arterioles, resulting in swelling of glomerular capillaries. Continuous radiation ther...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61P39/02
CPCA61K36/185A61K36/258A61K36/59A61K36/74A61K36/8967A61K2236/331A61K2300/00
Inventor 韩东河金梅花吕鹏飞王冠男金文龙王鹏梅晰凡
Owner JINZHOU MEDICAL UNIV
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