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A strontium apatite bone cement and its preparation method

A technology of strontium apatite and bone cement, which is applied in the field of strontium apatite bone cement and its preparation, can solve the problems of unreported, high product crystallinity, no control and optimization of particle size, etc., and achieve easy mixing and uniform increase of specific surface area , the effect of reducing hair volume

Active Publication Date: 2019-12-27
山东明德生物医学工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is basically prepared by wet method, high-temperature sintering, or solid-state reaction, high-temperature sintering, etc. The product has high crystallinity, which is not conducive to the release and degradation of strontium ions; and when added to bone cement powder, the particle size of each powder has no difference. Optimized control resulting in less cement mixing and short injection times
[0005] The present invention selects polyacrylate, strontium apatite, calcium sulfate, and barium sulfate in a specific particle size range as powder components, controls the ratio to prepare strontium apatite bone cement, forms a particle size gradient, is easy to stir and mix the bone cement, and improves the bone cement The injectability of strontium apatite is mainly composed of strontium and phosphorus elements, supplemented by calcium elements, using a combination of hydrothermal and steam thermal methods, first hydrothermal, and then high temperature and high pressure to guide crystal growth to prepare crystals with controllable morphology The strontium apatite with low crystallinity and easy release and degradation has no report on the similar research content of the present invention

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  • A strontium apatite bone cement and its preparation method
  • A strontium apatite bone cement and its preparation method
  • A strontium apatite bone cement and its preparation method

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Experimental program
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preparation example Construction

[0036] Bone cement was prepared according to the following steps:

[0037] (1) Preparation of strontium apatite

[0038] First prepare a mixed solution A of strontium nitrate and calcium nitrate of 0.05-0.5 mol / L, and prepare diammonium hydrogen phosphate solution B with the same concentration as A; in solution A, the ratio of strontium to the total molar amount of strontium and calcium is not less than 0.15, preferably strontium The ratio to the total molar amount of strontium calcium is not less than 0.4;

[0039] In a water solution at 90-95°C, according to the volume ratio A:B is 1.67, add B to A, stir and mix to obtain a cloudy precipitate suspension; add nitric acid to adjust the pH value to 2, the solution becomes clear, and stir for 0.5-1h After adding ammonia water, a white precipitate gradually precipitates out, adjust the pH value to 9-11, and react for 2 hours;

[0040] Finally, react the white precipitate in a gaseous environment with a temperature of 100-300° C...

Embodiment 1

[0045] The particle size distribution range of PMMA is 53-100 μm, that of strontium apatite is 5-37 μm, and that of barium sulfate is 5-10 μm.

[0046] (1) Preparation of strontium apatite

[0047] First configure 200mL×0.05mol / L strontium nitrate and calcium nitrate mixed solution A, configure 100mL×0.05mol / L diammonium hydrogen phosphate solution B; in solution A, the ratio of strontium to the total molar amount of strontium calcium is 0.4;

[0048] In a water solution at 95°C, according to the volume ratio A:B is 1.67, add 100mL B into 167mLA, stir and mix to obtain a cloudy precipitate suspension; add nitric acid to adjust the pH value to 2, the solution becomes clear, stir for 0.5h and then Add ammonia water, a white precipitate precipitates out, adjust the pH value to 10, and react for 2 hours;

[0049] Finally, react in a gas environment with a temperature of 250°C and a pressure of 1.5 MPa for 24 hours, dry, and sieve to obtain strontium apatite;

[0050] (2) Prepara...

Embodiment 2

[0057] PMMA particle size distribution range is selected as 10-53 μm, strontium apatite is 2.5-20 μm, barium sulfate is 0.2-8 μm

[0058] (1) Preparation of strontium apatite

[0059] First configure 200mL×0.5mol / L strontium nitrate and calcium nitrate mixed solution A, configure 100mL×0.5mol / L; in solution A, the ratio of strontium to the total molar amount of strontium calcium is 0.15;

[0060] In water solution at 90°C, according to the volume ratio A:B is 1.67, add 100mL B into 167mLA, stir and mix to get a cloudy precipitate suspension; add nitric acid to adjust the pH value to 2, the solution becomes clear, stir for 1 hour before adding Ammonia, a white precipitate gradually precipitated, adjust the pH value to 11, and react for 2 hours;

[0061] Finally, react in a gas environment with a temperature of 300°C and a pressure of 2 MPa for 3 hours, dry, and sieve to obtain strontium apatite;

[0062] (2) Preparation of bone cement

[0063] Weigh 40% PMMA, 50% strontium a...

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Abstract

The invention relates to fermorite bone cement and a preparation method. A hydrothermal and steam heating combined method is adopted for preparing fermorite having low crystalline and being capable of releasing and degrading easily but not sintered at high temperature; powder contains fermorite, calcium sulfate, polyacrylate and barium sulfate, liquid contains methyl methacrylate monomer, N,N dimethyl-p-toluidine and hydroquinone, in the bone cement powder, the size distribution range of polyacrylate is 10-150 [mu] m, the size distribution range of barium sulfate is 0.1-20 [mu] m, the size distribution range of fermorite is 2.5-53 [mu] m, and the size distribution range of calcium sulfate is 5-53 [mu] m. The particle size levels form particle size match, so that the bulk volume of the bone cement powder is reduced, the specific surface area of the powder particles is increased, therefore, the liquid wetting for the bone cement is benefited, and the bone cement realizing easy mixing, and having good injection and high mechanical strength is prepared; and the compressive strength of the prepared fermorite bone cement is 60MPa or above.

Description

technical field [0001] The invention relates to a strontium apatite bone cement and a preparation method thereof, which are mainly used in the field of orthopedic materials. Background technique [0002] Polyacrylate bone cement is currently the most clinically used bone cement, which consists of powder and liquid. The main component of the powder is polymethyl methacrylate (PMMA), and the main component of the liquid is methyl methacrylate monomer. PMMA bone cement can be injection molded and made into any shape, and has high mechanical strength, but at the same time, PMMA bone cement still has some limitations [Belkoff, S.M et al...Temperature measurement during polymerization of polymethylmethacrylate used for vertebroplasty.Spine.28: 1555-1559], such as the monomer has certain toxicity, poor biocompatibility, and cannot be absorbed and degraded after being injected into the human body. The reaction may cause neurological impairment failures of fixation and function in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/02A61L31/14C01B25/45
CPCA61L31/022A61L31/028A61L31/048A61L31/14A61L2400/06C01B25/45C01P2004/03C01P2004/61C08L33/08C08L33/12
Inventor 李朝阳崔永顺夏文飞吕维加
Owner 山东明德生物医学工程有限公司
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